Method of making novel separation media

• US 5,211,993 A
• Filed: 12/10/1990
• Issued: 05/18/1993
• Est. Priority Date: 12/10/1990
• Status: Expired due to Fees

• Current Assignee: Surface Technology Limited Liability Company
• Original Assignee: Surface Technology Limited Liability Company
• Inventors: Kolesinski, Henry S.
• Primary Examiner(s): Dawson, Robert A.
• Assistant Examiner(s): KIM, SUN U
• Application Number:
  US07/625,204
• Time in Patent Office: 890 Days
• Field of Search: 210/198.2, 210/656, 210/635, 210/502.1, 204/165, 204/168, 55/16, 55/68, 55/158, 55/67, 55/386, 427/34, 427/201, 427/248.1, 427/255, 427/220, 427/488, 427/533, 502/439, 502/402, 502/401, 522/153, 522/154
• US Class Current: 427/488
• CPC Class Codes: B01J 20/261 obtained by reactions only involving carbon to carbon unsaturated bonds macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F
• CPC Class Codes: B01J 20/264 derived from different types of monomers, e.g. linear or branched copolymers, block copolymers, graft copolymers
• CPC Class Codes: B01J 20/267 Cross-linked polymers
• CPC Class Codes: B01J 20/28004 Sorbent size or size distribution, e.g. particle size
• CPC Class Codes: B01J 20/2803 Sorbents comprising a binder, e.g. for forming aggregated, agglomerated or granulated products
• CPC Class Codes: B01J 20/28057 Surface area, e.g. B.E.T specific surface area
• CPC Class Codes: B01J 20/28078 Pore diameter
• CPC Class Codes: B01J 20/286 Phases chemically bonded to a substrate, e.g. to silica or to polymers
• CPC Class Codes: B01J 20/287 Non-polar phases; Reversed phases
• CPC Class Codes: B01J 20/3042 Use of binding agents; addition of materials ameliorating the mechanical properties of the produced sorbent
• CPC Class Codes: B01J 20/3092 Packing of a container, e.g. packing a cartridge or column of chromatography columns B01D15/206
• CPC Class Codes: B01J 20/3204 Inorganic carriers, supports or substrates
• CPC Class Codes: B01J 20/3217 Resulting in a chemical bond between the coating or impregnating layer and the carrier, support or substrate, e.g. a covalent bond
• CPC Class Codes: B01J 20/327 Polymers obtained by reactions involving only carbon to carbon unsaturated bonds
• CPC Class Codes: B01J 20/3276 Copolymers
• CPC Class Codes: B01J 20/3282 Crosslinked polymers
• CPC Class Codes: B01J 2219/0894 Processes carried out in the presence of a plasma
• CPC Class Codes: B01J 2220/54 Sorbents specially adapted for analytical or investigative chromatography
• CPC Class Codes: B01J 2220/58 Use in a single column
• CPC Class Codes: B05D 3/147 Curing

Abstract

Method of chromatographically separating a mixture by contacting said mixture under chromatographic separation conditions with a chromatographic separation stationary phase comprising a polymer formed by coating substantially all of the surfaces of a microporous, comminuted substrate material with a monomer that is subsequently polymerized in situ with a cold-gas plasma discharge.

Claims

1. Method of making a chromatographically active support material, said method comprising the steps of:

coating the surfaces of a comminuted inorganic substrate material with a monomer selected from those monomers which, when polymerized, possess chromatographic properties; and

exposing said monomer coated on said surface to an inert gas plasma for a time and of an intensity sufficient to induce polymerization of said monomer.

2. Method as defined in claim 1 wherein said monomer is vinyl stearate.

3. Method as defined in claim 1 wherein said monomer is vinyl octadecyl ether.

4. Method as defined in claim 1 wherein said monomer is polyethylene glycol 1000 monomethacrylate.

5. Method as defined in claim 1 wherein said monomer is stearyl methacrylate.

6. Method as defined in claim 1 wherein said monomer is in solution during said step of coating.

7. Method as defined in claim 6 including the step of adding a polymeric material to said solution in sufficient amount to serve as a binder to aid the step of coating.