Frequency domain optical imaging using diffusion of intensity modulated radiation

• US 5,213,105 A
• Filed: 12/04/1990
• Issued: 05/25/1993
• Est. Priority Date: 12/04/1990
• Status: Expired due to Term

• Current Assignee: Board of Trustees of The University of Illinois
• Original Assignee: Research Corporation Technologies
• Inventors: Mantulin, William W., vandeVen, Martin J., Gratton, Enrico
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): Nasser, Jr., Robert L.
• Application Number:
  US07/624,385
• Time in Patent Office: 903 Days
• Field of Search: 128/664-665
• US Class Current: 600/473
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

Arrangements are disclosed for producing images based upon diffusional wave theory and frequency domain analysis. A medium to be imaged is illuminated with amplitude modulated radiation, and diffusional radiation transmitted or reflected by the medium is detected at a plurality of detection locations, as by a television camera. The phase and also the amplitude demodulation of the amplitude modulated diffusional radiation is detected at each detection location. A relative phase image and also a demodulation amplitude image of the medium are then generated from respectively the detected relative phase values and the detected demodulation amplitudes of the diffusional radiation at the plurality of locations. The present invention is particularly suited for medical applications for generating images of internal anatomical details of the body by using a near infrared amplitude modulated source for illumination of the body. In such medical applications, the body is illuminated with near infrared radiation having a wavelength between 600 and 1200 nanometers which is amplitude modulated at a frequency in the megahertz to gegihertz range, and internal images of the patient are generated for medical diagnosis. In preferred embodiments, a laser is utilized to generate the near infrared radiation near or below a 10 watt power level which is coupled by fiber optic cables to the body of the patient. Detection is also with fiber optic cables placed in direct contact with an opposed surface of the body which couple the transmitted diffusional radiation to an image intensifier placed in front of a television camera detector. The gain of the image intensifier is modulated at a frequency to obtain a heterodyned output frequency of less than 60 hertz which is within the detection bandwidth of the television camera.

Claims

1. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis comprising:

a. illuminating a medium with light radiation which is amplitude modulated;

b. detecting amplitude modulated diffusional radiation from the medium at a plurality of detection locations forming a detection area, including detecting the phase of the amplitude modulated diffusional radiation at each detection location, and detecting the demodulation of the amplitude modulated diffusional radiation at each detection location; and

c. displaying an image of the medium comprised of data from the detected relative phase or demodulation of the amplitude modulated diffusional radiation at each detection location.

2. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said amplitude modulation is at a frequency in the megahertz to gegihertz range.

3. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 2, including illuminating a patient with near infrared radiation having a wavelength between 600 and 1200 nanometers, amplitude modulating the radiation at a frequency in the megahertz to gegihertz range, and displaying internal images of the patient for medical diagnosis.

4. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 3, said illuminating step including utilizing a laser to generate near infrared radiation having a wavelength between 680 and 850 nanometers.

5. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 3, wherein said illuminating step is with fiber optic cables placed in direct contact with the body of the patient.

6. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 5, wherein said detecting step is with fiber optic cables placed in direct contact with the body of the patient.

7. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 3, wherein said detecting step is with a camera type detector.

8. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 7, including an image intensifier in front of the camera detector, and modulating the gain of the image intensifier at a frequency to obtain a heterodyned output frequency for the camera detector of less than 60 hertz.

9. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 3, wherein said illuminating step is below 10 watt power level.

10. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 3, further including utilizing a Doppler frequency shift mode to measure the flow rate of fluids in the patient.

11. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said step of displaying includes:

a. displaying a relative phase image of the medium comprised of the detected relative phase values of the diffusional radiation at the plurality of detection locations; and

b. displaying a demodulation amplitude image of the medium comprised of the detected demodulation amplitudes of the diffusional radiation at the plurality of detection locations.

12. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, including detecting phase and modulation amplitude data at different modulation frequencies and different illumination wavelengths, and utilizing a computer programmed to produce false color representations, smoothing, filtering or contrast enhancement.

13. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, including the step of storing in memory the detected phase and modulation amplitude data.

14. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said step of detecting comprises detecting diffusional radiation transmitted by the media.

15. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said step of detecting comprises detecting diffusional radiation reflected by the media.

16. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said step of illuminating is with a pulsed neutron source.

17. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said detecting step comprises detecting radiation with a camera and wherein each detection location comprises a pixel of the camera detector.

18. A method for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 1, wherein said illuminating step comprises illuminating the medium with light which is amplitude modulated.

19. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis comprising:

a. means for illuminating a medium with light radiation which is amplitude modulated;

b. means for detecting amplitude modulated diffusional radiation from the medium at a plurality of detection locations forming a detection area, including means for detecting the phase of the amplitude modulated diffusional radiation at each detection location, and means for detecting the demodulation of the amplitude modulated diffusional radiation at each detection location; and

c. means for displaying an image of the medium comprised of data from the detected relative phase or demodulation of the amplitude modulated diffusional radiation at each detection location.

20. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said amplitude modulation of said illuminating means is at a frequency in the megahertz to gegihertz range.

21. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 20, wherein said illuminating means includes means for illuminating a patient with near infrared radiation having a wavelength between 600 and 1200 nanometers, amplitude modulating the radiation at a frequency in the megahertz to gegihertz range, and means for displaying internal images of the patient for medical diagnosis.

22. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 21, said illuminating means including a laser means for generating near infrared radiation having a wavelength between 680 and 850 nanometers.

23. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 21, wherein said illuminating means includes fiber optic cables placed in direct contact with the body of the patient.

24. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 23, wherein said detecting means includes fiber optic cables placed in direct contact with the body of the patient.

25. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 21, wherein said detecting means includes a camera type detector.

26. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 25, including an image intensifier in front of the camera detector, and means for modulating the gain of the image intensifier at a frequency to obtain a heterodyned output frequency for the camera detector of less than 60 hertz.

27. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 21, wherein said illuminating means operates below 10 watt power level.

28. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 21, further including means for detecting a Doppler frequency shift to measure the flow rate of fluids in the patient.

29. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said displaying means includes:

a. means for displaying a relative phase image of the medium comprised of the detected relative phase values of the diffusional radiation at the plurality of detection locations; and

b. means for displaying a demodulation amplitude image of the medium comprised of the detected demodulation amplitudes of the diffusional radiation at the plurality of detection locations.

30. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, including means for detecting phase and modulation amplitude data at different modulation frequencies and different illumination wavelengths, and a computer programmed to produce false color representations, smoothing, filtering or contrast enhancement.

31. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, including a memory means for storing in memory the detected phase and modulation amplitude data.

32. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said detecting means detects diffusional radiation transmitted by the media.

33. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said detecting means detects diffusional radiation reflected by the media.

34. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said illuminating means includes a pulsed neutron source.

35. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said detecting means comprises a camera and wherein each detection location comprises a pixel of the camera detector.

36. A system for producing images based upon diffusion of intensity modulated radiation and frequency domain analysis as claimed in claim 19, wherein said illuminating means illuminates the media with light which is amplitude modulated.