Device for examining the functions of the endothelium or the intima of blood vessels

• US 5,213,577 A
• Filed: 12/21/1990
• Issued: 05/25/1993
• Est. Priority Date: 12/22/1989
• Status: Expired due to Term

• Current Assignee: Siemens Healthcare Diagnostics Incorporated (Siemens AG)
• Original Assignee: Michael Kratzer
• Inventors: Kratzer, Michael
• Primary Examiner(s): RIMELL, SAMUEL G
• Assistant Examiner(s): Owens, Kerry
• Application Number:
  US07/629,811
• Time in Patent Office: 886 Days
• Field of Search: 604/96-101, 606/191-194
• US Class Current: 604/101.05
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 2017/22054 with two balloons
• CPC Class Codes: A61B 2017/22082 after introduction of a substance
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Abstract

The invention relates to a device for examining the functions of the endothelium or the intima of blood vessels. A tube (1) has at least one outlet (6) and at least one inlet (7) spaced along the wall thereof. Outlet (6) communicates with a connector (8), inlet (7) communicates with another connector (9). Connectors (8, 9) are provided in tube (1) at the end thereof projecting from blood vessel (4).

Claims

1. A device for examining a function of the endothelium or the intima of a blood vessel, comprising:

a tube having in its wall at least one outlet and an inlet in spaced relationship to each other;

first and second connectors;

said outlet and said inlet communicating with said first and second connectors, respectively;

said first and second connectors extending from an end of the tube projecting from the blood vessel;

a reservoir communicating with the first connector for holding and discharging a solution through the first connector and the outlet into the blood vessel; and

analysis means communicating with the second connector for receiving a solution from the blood vessel through the inlet and second connector;

said analysis means detecting differences between the solution from the reservoir and the solution from the blood vessel to determine a function of the endothelium or the intima of the blood vessel.

2. A device as in claim 1, including seal means provided laterally adjacent said outlet and said inlet, respectively, and on opposite sides of an area defined by the outlet and the inlet;

said seal means adapted to selectively provide a seal between the periphery of the tube and an inner wall of the blood vessel.

3. A device as in claim 2, wherein said seal means includes a plastic inflatable seal member concentrically surrounding the tube and having first and second spaced annular zones in which the material of the seal member is more flexible than the material in other areas of the seal member, so that said zones may flex outwardly in response to a medium inside the seal member being pressurized.

4. A device as in claim 3, wherein the seal member includes a third zone extending between the first and second zones along only one portion of the circumference of the seal member, said third zone consisting of said comparatively more flexible material than the other areas of the seal member.

5. A device as in claim 2, wherein said seal means includes an annular inflatable cuff-like plastic member placed over the tube and having a central portion and end portions, said end portions being comparatively more flexible than said central portion, and a conduit sealingly connected with the cuff-like plastic member in such a manner that a medium in the conduit and in the cuff-like plastic member when pressurized causes the end portions to flex outwardly to establish seals with the inner wall of the blood vessel.

6. A device as in claim 5, wherein said conduit concentrically surrounds tube.

7. A device as in claim 5, wherein said annular inflatable cuff-like plastic member has an inner diameter which is greater than the outer diameter of the tube when the medium is pressurized so as to form a passage for blood between the tube and the cuff-like plastic member.

8. A device as in claim 5, wherein said conduit extends inside the tube and sealingly extends through the wall of the tube.

9. A device as in claim 1, further comprising:

a second tube disposed inside the first tube with one end of the second tube being located inside the first tube;

a first partition in the first tube spaced from the one end of the second tube and sealing the lumen of the first tube;

a second partition disposed--as seen from the first partition in the first tube--behind the one end of the second tube to seal the annular space between the second tube and the first tube said outlet communicating with the space between the first and second partitions; and

said inlet being located in the area behind the second partition as seen from the first partition in the first tube.

10. A device as in claim 1, wherein the tube has an end portion tapered to a tip for introduction in a blood vessel.

11. A device as in claim 9, wherein the first tube has an end portion for extending into a blood vessel and which has a shape of a head portion rounded at its free end.

12. A device as in claim 11, wherein the head portion has a passage therein extending from the free end thereof to one side of the head portion, said passage being provided to receive a guide wire.

13. A device as in claim 1, wherein the tube has a plurality of outlets and a plurality of inlets distributed along circumferential areas of the tube.

14. A device as in claim 3, wherein said outlet and said inlet have the form of respective openings in the wall of the tube, said seal member having sealed openings in the area of the openings in the tube.

15. A device as in claim 3, wherein said outlet and said inlet each have the form of a short tubular stub extending through the wall of the tube, with the plastic seal member having sealed openings in the areas of said stubs.

16. A device as in claim 1, wherein the tube is metal.

17. A device as in claim 9, wherein said second tube consists of plastic or metal.