Method for making a capsule-shaped tablet
First Claim
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1. A method of manufacturing a pharmaceutical tablet comprising:
- filling a die cavity partially with a first blend of solid particulate excipients and active substances, and a first coloring agent;
leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend;
filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, and a second coloring agent;
compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; and
removing the capsule-shaped tablet from the die cavity.
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Abstract
A method for making a multi-characteristic, bi-layer, capsule-shaped tablet by filling a die with a blend of one or more excipients and one or more active substances, including a first distinguishing ingredient, e.g., a first coloring agent, leveling the first blend and cleaning the die walls above the first blend, adding a second blend including a second distinguishing ingredient, e.g., a second coloring agent, and compressing both blends longitudinally in the die into the shape of a two component capsule. The tablet is coated with a clear coating, such as gelatin, to provide a solid medicament with the appearance of a gelatin capsule.
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Citations
44 Claims
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1. A method of manufacturing a pharmaceutical tablet comprising:
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filling a die cavity partially with a first blend of solid particulate excipients and active substances, and a first coloring agent; leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend; filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, and a second coloring agent; compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; and removing the capsule-shaped tablet from the die cavity. - View Dependent Claims (2, 3)
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4. A method of manufacturing a pharmaceutical tablet comprising:
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filling a die cavity partially with a first blend of solid particulate excipients and active substances, and a first coloring agent; rotating the die cavity on a rotary press; leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend; rotating said die cavity on said rotary press; filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, and a second coloring agent; rotating said die cavity on said rotary press; compressing said first blend and said second blend between a lower punch and an upper punch along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; rotating said die cavity on said rotary press; and ejecting the layered capsule-shaped tablet from the rotary press. - View Dependent Claims (5, 6)
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7. A method of manufacturing a pharmaceutical tablet comprising:
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filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient; leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend; filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient; compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; and removing the capsule-shaped tablet from the die cavity. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of manufacturing a pharmaceutical tablet comprising:
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filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient; rotating the die cavity on a rotary press; leveling said first blend in said die cavity and clearing the walls of said die cavity above said first blend to define a clear line of demarcation at the upper circumferential edge of said first blend; rotating said die cavity on said rotary press; filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient; rotating said die cavity on said rotary press; compressing said first blend and said second blend between a lower punch and an upper punch along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; rotating said die cavity on said rotary press; and ejecting the layered capsule-shaped tablet from the rotary press. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A method of manufacturing a pharmaceutical tablet comprising:
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filling a die cavity partially with a first blend of solid particulate excipients and active substances, including a first distinguishing ingredient; leveling said first blend in said die cavity; filling the unfilled portion of said die cavity with a second blend of solid particulate excipients and active substances, including a second distinguishing ingredient; compressing said first blend and said second blend along the longitudinal axis of said die cavity to form a layered capsule-shaped tablet; and removing the capsule-shaped tablet from the die cavity. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44)
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Specification