1,4-dihydropyridines useful as pharmaceuticals
First Claim
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1. A compound of the formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein:
- R is a thienyl, benzothienyl, furyl or benzofuranyl group, said group being optionally substituted by up to three substituents each independently selected from the group consisting of nitro, halo, (C1 -C4)alkyl, (C1 -C4)alkoxy, hydroxy, aryl(C1 -C4)alkoxy, fluoro (C1 -C4)alkoxy, (C1 -C4)alkylthio, (C1 -C4)alkanesulphonyl, trifluoromethyl and cyano;
R1 is hydrogen or (C1 -C4)alkyl;
R2 is pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl;
R3 is (C1 -C4)alkyl or aryl(C1 -C4)alkyl; and
R4 is an imidazolyl or triazolyl group, said group being optionally benzo-, pyrido-, pyridazino-, pyrimido- or pyrazino-fused and optionally substituted by up to three substituents each independently selected from the group consisting of (C1 -C4)alkyl, (C1 -C4)alkoxy, trifluoromethyl and halo.
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Abstract
The invention provides compounds of the formula: ##STR1## The variables are defined in the specification. The compounds are useful e.g. for the curative or prophylactic treatment of allergic conditions.
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Citations
11 Claims
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1. A compound of the formula ##STR13## or a pharmaceutically acceptable salt thereof, wherein:
- R is a thienyl, benzothienyl, furyl or benzofuranyl group, said group being optionally substituted by up to three substituents each independently selected from the group consisting of nitro, halo, (C1 -C4)alkyl, (C1 -C4)alkoxy, hydroxy, aryl(C1 -C4)alkoxy, fluoro (C1 -C4)alkoxy, (C1 -C4)alkylthio, (C1 -C4)alkanesulphonyl, trifluoromethyl and cyano;
R1 is hydrogen or (C1 -C4)alkyl; R2 is pyridyl, pyrimidinyl, pyridazinyl or pyrazinyl; R3 is (C1 -C4)alkyl or aryl(C1 -C4)alkyl; and R4 is an imidazolyl or triazolyl group, said group being optionally benzo-, pyrido-, pyridazino-, pyrimido- or pyrazino-fused and optionally substituted by up to three substituents each independently selected from the group consisting of (C1 -C4)alkyl, (C1 -C4)alkoxy, trifluoromethyl and halo. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- R is a thienyl, benzothienyl, furyl or benzofuranyl group, said group being optionally substituted by up to three substituents each independently selected from the group consisting of nitro, halo, (C1 -C4)alkyl, (C1 -C4)alkoxy, hydroxy, aryl(C1 -C4)alkoxy, fluoro (C1 -C4)alkoxy, (C1 -C4)alkylthio, (C1 -C4)alkanesulphonyl, trifluoromethyl and cyano;
Specification
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Current AssigneePfizer Inc.
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Original AssigneePfizer Inc.
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InventorsFray, Michael J., Cooper, Kelvin
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Primary Examiner(s)DENTZ, BERNARD I
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Application NumberUS07/762,013Time in Patent Office615 DaysField of Search546/118, 546/256, 546/117, 514/300, 514/303, 514/248, 514/249, 514/253, 514/256, 514/262, 514/266, 514/333, 544/236, 544/238, 544/254, 544/276, 544/277, 544/333, 544/350, 544/405US Class Current514/248CPC Class CodesC07D 401/14 containing three or more he...C07D 405/14 containing three or more he...C07D 409/14 containing three or more he...C07D 471/04 Ortho-condensed systems
