Method for delivering an active substance topically or percutaneously

• US 5,215,520 A
• Filed: 09/17/1991
• Issued: 06/01/1993
• Est. Priority Date: 09/17/1991
• Status: Expired due to Fees

• Current Assignee: Centre International de Recherches Dermatologiques Galderma
• Original Assignee: Centre International de Recherches Dermatologiques Galderma
• Inventors: Green, Philip, Shroot, Braham
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US07/760,982
• Time in Patent Office: 623 Days
• Field of Search: 604/20, 128/799, 128/803, 128/419 R
• US Class Current: 604/20
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61N 1/30 Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

A method for the topical or percutaneous administration of a cosmetic or pharmaceutically active substance involves applying an electric current to an area of the skin, ceasing to apply the electric current to this area of the skin and then applying an active substance to at least a part of this area of the skin in the absence of an electric current being applied thereto.

Claims

1. A method for the topical or percutaneous administration of at least one cosmetic or pharmaceutically active substance comprising, in a first stage, applying to an area of the skin an electric current, ceasing to apply said electric current and, in a second stage, applying an active substance to be administered to at least a part of said area of the skin in the absence of an electric current being applied thereto.

2. The method of claim 1 wherein the step of applying an electric current includes the step of applying a current having a density of from 0.01 to 0.5 mA/cm².

3. The method of claim 1 wherein the step of applying an electric current includes the step of applying a pulsed current of 0.05 to 40 KHz with an off/on ratio of 1:

1 to 8;

1.

4. The method of claim 1 wherein the step of applying an electric current in said first stage includes applying said current for a period of time ranging from 2 minutes to 6 hours.

5. The method of claim 1 wherein the step of applying an active substance to said area of the skin in said second stage includes applying said active substance thereto within 30 minutes after ceasing to apply electric current in said first stage.

6. The method of claim 1 wherein said second stage is carried out immediately after ceasing to apply electric current in said first stage.

7. The method of claim 1 which includes cleaning the skin between said first stage and said second stage.

8. A method for the topical or percutaneous administration of at least one cosmetic or pharmaceutically active substance comprising, in a first stage, applying to an area of the skin an electric current, ceasing to apply said electric current and cleaning said area of the skin to which the electric current in said first stage was applied, and in a second stage applying an active substance to be administered to at least a part of said area of the skin in the absence of an electric current being applied thereto.