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Integral multilayer analytical element

  • US 5,215,716 A
  • Filed: 03/11/1991
  • Issued: 06/01/1993
  • Est. Priority Date: 12/28/1987
  • Status: Expired due to Term
First Claim
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1. In an integral multilayer analytical element comprising a reagent layer containing an indicator reagent composition capable of producing a detectable change corresponding to an analyte and a porous spreading layer composed of a fibrous fabric superposed on the reagent layer, the improvement which comprises said fabric being composed of fibers having a roughed surface formed by alkali etching, the fabric having an exposed and unexposed face, the fibers having a roughed surface comprising roughed portions being at least on the exposed face of the fabric, and wherein the depth of the roughness of the roughed surface in the direction perpendicular to the fiber axis is from 0.2 to 0.7 μ

  • m, and the roughed portions being further roughed with a fine roughness of a depth from about 50 nm to 200 nm, the density of the roughness of the roughed surface being from about 1 to 200/μ

    m.

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