Device and method for intra-vascular optical radial imaging

• US 5,217,456 A
• Filed: 02/24/1992
• Issued: 06/08/1993
• Est. Priority Date: 02/24/1992
• Status: Expired due to Term

• Current Assignee: PDT Cardiovascular Incorporated
• Original Assignee: PDT Cardiovascular Incorporated
• Inventors: Narciso, Hugh L. Jr.
• Primary Examiner(s): ASCHENBRENNER, PETER
• Application Number:
  US07/840,478
• Time in Patent Office: 470 Days
• Field of Search: 606/2, 606/3, 606/7, 606/13-18, 128/395-398
• US Class Current: 606/15
• CPC Class Codes: A61B 1/00177 for 90 degrees side-viewing
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence

Abstract

An intra-vascular optical radial imaging system comprising an intra-vascular guidewire-compatible catheter, a source of illumination and a synchronous fluorescence detector. The catheter is inserted into a blood vessel until the tip is adjacent to a section of vessel to be imaged. A narrow beam of light emanating radially from an aperture underlying the segment to be imaged repetitively illuminates segments of the wall of the vessel in a scanning or sweeping manner with the light of a wavelength that induces fluorescence in molecules in the tissue. Fluorescence from molecules in the illuminated tissue enters the catheter through the aperture and is conveyed to a spectral analyzer. Properties of the fluorescence signal are characteristic of the particular tissue and may be used to differentiate healthy tissue from atherosclerotic plaque. The method yields not only the longitudinal position of a lesion along a vessel but also the cylindrical coordinates by determining the circular or angular position of the lesion on the interior wall of the vessel.

Claims

1. A guidewire compatible intra-vascular catheter for intra-vascular optical radial imaging, at least a portion of said intra-vascular catheter being insertable into a blood vessel, said insertable portion of said catheter comprising a hollow tubular member having a proximal end which receives light from a source of illumination and a distal end, and a central guidewire lumen forming a conduit therebetween, said insertable portion of said intra-vascular catheter further comprising a cylindrical optical fiber array surrounding and coaxial with said guidewire lumen, said array consisting of a multiplicity of individual optical fibers, each fiber terminating in a diffuser tip portion near the catheter'"'"'s distal end, and means for directing a narrow beam of light from the diffuser tip portion radially-outward to illuminate a target along the wall of the vessel to induce fluorescence in molecules therein, and means for receiving the return fluorescent signal from the tissue.

2. The intra-vascular catheter of claim 1 wherein said distal end is tapered to facilitate entry into a blood vessel.

3. The intra-vascular catheter of claim 1 wherein said means for directing said narrow beam of light radially outward from the diffuser tip comprises a rotatable opaque tubular member coaxially surrounding said cylindrical optical fiber array, said opaque tubular member having a longitudinal aperture in the wall thereof, said longitudinal aperture overlying at least a portion of a diffuser tip.

4. The intra-vascular catheter of claim 2 wherein said means for directing the narrow beam of light from the diffuser tip portion radially outward from the diffuser tip portion to illuminate a target and receive fluorescence light from the target comprises a rotatable opaque tubular member coaxially surrounding said cylindrical optical fiber array, said opaque tubular member having a longitudinal aperture in the wall thereof, said longitudinal aperture overlying at least a portion of the diffuser tip portion.

6. A method of imaging tissue on the interior wall of a tubular member comprising the steps of:

(a) inserting the distal end of a guidewire into said tubular member until the distal end is adjacent to the tissue to be imaged;

(b) inserting the distal end of the intra-vascular catheter of claim 1 over the guidewire and advancing the catheter into the vessel until the distal tip of the catheter is adjacent to the tissue to be imaged;

(c) continuously sweeping a narrow illuminating beam of light over the surrounding tissue in to induce fluorescence therein; and

(d) collecting the fluorescence light emanating from the illuminated tissue and measuring the wavelength and amplitude of the fluorescence light.

7. A method for imaging tissue on the interior wall of a tubular member comprising the steps of:

(a) inserting the distal end of a guidewire into said tubular member until the distal end is adjacent to the tissue to be imaged;

(b) inserting the distal end of the intra-vascular catheter of claim 2 over the guidewire and advancing the catheter into the vessel until the distal tip of the catheter is adjacent to the tissue to be imaged;

(c) continuously sweeping a narrow beam of illuminating radially the surrounding tissue in discrete increments to induce fluorescence; and

(d) collecting the fluorescence light from the illuminated tissue and measuring the wavelength and amplitude of the fluorescence signal.

5. A device for intra-vascular optical radial imaging comprising a guidewire compatible intra-vascular catheter having a distal end dimensioned for insertion into a patient'"'"'s blood vessel and a proximal end and a tubular body portion therebetween, said body portion comprising a plurality of coaxial concentric tubular members in which:

(a) the outermost tubular member is an optically transparent sheath;

(b) an optically opaque tube underlies said optically transparent sheath, said optically opaque tube being rotatably mounted to permit the opaque tube to spin, the opaque tube having an aperture in the wall thereof;

(c) an optically transmissive member having a diffuser tip in optical communication therewith underlies said spinning tube; and

(d) an optically reflective center tube underlies said optically transmissive member, the inner walls of which center tube form a guidewire lumen, said optically opaque tube being spaced from said overlying optically transparent sheath and said underlying optically transmissive member by an air space, said air space being maintained by at least two cylindrical spacer bearings surrounding said optically opaque tube.