Coaxial lead screw drive syringe pump

• US 5,219,099 A
• Filed: 09/06/1991
• Issued: 06/15/1993
• Est. Priority Date: 09/06/1991
• Status: Expired due to Fees

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Spence, Charles F., Clark, Steven M.
• Primary Examiner(s): Kashnikow, Andres
• Assistant Examiner(s): Bomberg, Kenneth
• Application Number:
  US07/755,804
• Time in Patent Office: 648 Days
• Field of Search: 222/325, 222/333, 222/390, 604/154, 604/155, 604/156, 604/211
• US Class Current: 222/325
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/1458 Means for capture of the plunger flange
• CPC Class Codes: B01L 3/0227 Details of motor drive means B01L3/0231, B01L3/0234 take precedence
• CPC Class Codes: G01F 11/021 of the piston type G01F11/04 takes precedence

Abstract

A syringe pump, uses a stepping motor to rotate a lead screw with precision and in turn advance a zero-backlash ball nut or vice-versa to drive the syringe plunger. This invention is designed to eliminate virtually all forces that are not coaxially aligned with the plunger'"'"'s axis by utilizing a drive shaft kinematically supported on a reference member. The barrel of the syringe is kinematically supported on the reference member with its axis aligned with the axis of the drive shaft. The drive shaft is advanced by the ball nut and drive shaft assembly to drive the plunger which is kinematically supported at one end by the end of the drive shaft and at the other end by the internal wall of the barrel.

Claims

1. A syringe pump comprising:

a syringe having a barrel with an axis and a plunger having an end extending outside of said barrel and having an axis coaxially aligned with said barrel axis,

a reference member,

a motor supported by said reference member,

a drive shaft coaxial with said motor for imparting translational motion of said plunger in said barrel, said drive shaft having an axis coaxially aligned with said axis of said barrel,

means for coaxially coupling said drive shaft to the outside end of said plunger,

a lead screw coaxially aligned with said drive shaft having a zero-backlash ball nut for producing translational motion of said drive shaft along said axis of said drive shaft, said drive shaft being coupled to said plunger with its axis aligned with said axis of said drive shaft,

means for kinematically supporting said barrel of said syringe on said reference member and constraining said barrel against translational and rotational motion while said plunger undergoes translation motion in response to translation motion of said drive shaft produced by said motor through said lead screw and zero-backlash ball nut, and

means for kinematically supporting said drive shaft on said reference member and constraining said drive shaft against translational and rotational motion except for translational motion along its axis produced by said motor through said lead screw and zero-backlash ball nut.

2. A syringe pump comprising:

a syringe having a barrel with an axis and a plunger having an end extending outside of said barrel and having an axis coaxially aligned with said barrel axis;

a reference member;

a motor supported by said reference member;

a drive shaft coaxial with said motor for imparting translational motion of said plunger in said barrel, said drive shaft having an axis coaxially aligned with said axis of said barrel;

means for coaxially coupling said drive shaft to the outside end of said plunger;

a lead screw coaxially aligned with said drive shaft having a zero-backlash ball nut for producing translational motion of said drive shaft along said axis of said drive shaft, said drive shaft being coupled to said plunger with its axis aligned with said axis of said drive shaft;

means for kinematically supporting said barrel of said syringe on said reference member and constraining said barrel against translational and rotational motion while said plunger undergoes translation motion in response to translation motion of said drive shaft produced by said motor through said lead screw and zero-backlash ball nut, and

means for kinematically supporting said drive shaft on said reference member and constraining said drive shaft against translational and rotational motion except for translational motion along its axis produced by said motor through said lead screw and zero-backlash ball nut;

said means for kinematically supporting said drive shaft comprising a first pair and a second pair of bearing balls affixed to said reference member, each pair being spaced apart transversely for support of said drive shaft on said reference member, said first and second pair of bearing balls being spaced apart along the length of said drive shaft, and

a pair of resilient clamping means, one directly over the axis of said drive shaft at the location of said first pair of bearing balls and one directly over the axis of said drive shaft at the location of said second pair of bearing balls.

3. A syringe pump as defined in claim 2 wherein each resilient clamping means is positioned at a respective location over one of said first and second pair of bearing balls in a plane perpendicular to said reference member and passing through the respective center of said one of said first and second pair of bearing balls.

4. A syringe pump as defined in claim 2 wherein said means for kinematically supporting said barrel of said syringe on said reference member comprises:

a first pair and a second pair of fixed balls, each pair being spaced apart along the length of said barrel for support of said barrel on said reference member, and

a pair of resilient clamping means, one directly over the axis of said barrel at the location of said first pair of fixed balls and one directly over the axis of said barrel at the location of said second pair of fixed balls.

5. A syringe pump as defined in claim 4 wherein each resilient clamping means is positioned at a respective location over one of said first and second pair of fixed balls in a plane perpendicular to said reference member and passing through the respective center of said one of said first and second pair of fixed balls.

6. A syringe pump as defined in claim 5 wherein said drive shaft is hollow to allow rotational and relative translational motion of said lead screw within said hollow drive shaft, including means for coaxially coupling said motor to said lead screw to impart rotational motion thereto in response to rotational motion of said motor, and means for connecting said zero-backlash ball nut in a fixed relationship to said drive shaft to impart translational motion of said drive shaft in response to rotational motion of said lead screw which is in turn rotated by said motor.

7. A syringe pump as defined in claim 6 wherein said means for coaxially coupling said motor to said lead screw is comprised of a flexible coupling to provide tolerance in coaxial alignment of said motor and said lead screw.

8. A syringe pump as defined in claim 7 comprising a thrust bearing support for said lead screw on said reference member between said flexible coupling and said zero-backlash ball nut.

9. A syringe pump as defined in claim 2 wherein said motor has a hollow shaft to allow translational motion of said lead screw through said hollow shaft of said motor including means for coupling said motor to said zero-backlash ball nut to impart rotational motion thereto in direct response to rotational motion of said motor, and means for coaxially coupling said lead screw to said drive shaft, whereby translational motion is imparted to said drive shaft in response to rotational motion of said motor.

10. A syringe pump for delivering precise, minute quantities of a liquid with repeatable precision from a syringe of the type having a barrel and a plunger in the barrel, the barrel and the plunger having coaxially aligned axes;

the pump comprising;

a reference member for supporting said pump;

a motor secured to said reference member and having an axis of motion that is coaxial with said barrel and plunger axes;

means coupling said motor to said plunger; and

a first kinematic support supporting said coupling means on said reference member and permitting motion of said coupling means and said plunger only along the axes of said plunger and said barrel;

wherein said coupling means comprises a drive shaft and wherein said first kinematic support comprises a first pair and a second pair of bearing balls affixed to said reference member, each pair being spaced apart transversely for support of said drive shaft on said reference member, said first and second pair of bearing balls being spaced apart along the length of said drive shaft, and

a pair of resilient clamping means, one directly over the axis of said drive shaft at the location of said first pair of bearing balls and one directly over the axis of said drive shaft at the location of said second pair of bearing balls.

11. The syringe pump recited in claim 10 further comprising a second kinematic support supporting said barrel on said reference member and constraining said barrel against motion during motion of said coupling means and said plunger.

12. The syringe pump recited in claim 11 wherein said second kinematic support comprises:

a first pair and a second pair of fixed balls, each pair being spaced apart along the length of said barrel for support of said barrel on said reference member, and

a pair of resilient clamping means, one directly over the axis of said barrel at the location of said first pair of fixed balls and one directly over the axis of said barrel at the location of said second pair of fixed balls.