Contamination-resistant dispensing and metering drop forming device

• US 5,219,101 A
• Filed: 01/17/1991
• Issued: 06/15/1993
• Est. Priority Date: 06/01/1989
• Status: Expired due to Term

• Current Assignee: Pall Corporation (Danaher Corporation), Merck & Co., Inc.
• Original Assignee: Pall Corporation (Danaher Corporation), Merck & Co., Inc.
• Inventors: Schlaudecker, Thomas E., Henley, Martin W., Bormann, Thomas, Matkovich, Vlado I.
• Primary Examiner(s): NOT, DEFINED
• Assistant Examiner(s): Milef, Boris
• Application Number:
  US07/642,158
• Time in Patent Office: 880 Days
• Field of Search: 222/189, 222/420, 222/421, 222/206, 222/212, 604/126, 604/295, 604/298, 210/321.64, 210/321.84, 210/500.38, 210/500.42
• US Class Current: 222/189.06
• CPC Class Codes: A61F 9/0008 Introducing ophthalmic products into the ocular cavity or retaining products therein putting in contact lenses A61F9/0061; introducing or retaining media in cavities of the body in general A61M31/00
• CPC Class Codes: A61J 1/145 using air filters
• CPC Class Codes: A61J 1/1456 using liquid filters
• CPC Class Codes: B65D 47/18 for discharging drops; Droppers droppers in general B01L3/00; pipettes connected to container closures B01L3/0282

Abstract

A device for dispensing liquids in drop form of substantially uniform size is provided which includes a container having a dropper tip including a passageway for ingress of air to and egress of liquid from the device, the passageway communicating between the container and an orifice in the dropper tip; means for temporarily reducing the volume of the container; and, disposed within the dropper tip, across the passageway, a microporous composite membrane with pores of a size to resist passage of contaminants. The membrane has a liquophilic component which permits delivery of drops of a liquid to a desired location outside the container and a liquophobic component which is adapted to resist the passage of such liquid but to permit the passage therethrough of air. Both the liquophilic and liquophobic components of the membrane (which intersects the passageway) communicate with the passageway. The surface area and pore size of the liquophilic component is so selected as to meter liquid being dispensed in drop form and avoid a stream of liquid from emerging from the dropper tip during normal use.

Claims

1. A device for dispensing liquids in drop form of substantially uniform size which comprises a container having a dropper tip including a passageway for ingress of air to and egress of liquid from said device, said passageway communicating between the container and an orifice in the dropper tip;

means for temporarily reducing the volume of the container; and

disposed within the dropper tip, across the passageway, a microporous composite membrane with pores of a size to resist passage of contaminants, said membrane having a liquophilic component permitting delivery of drops of a liquid to a desired location outside the container and a liquophobic component adapted to resist the passage of such liquid but to permit the passage therethrough of air, the surface area and pore size of said liquophilic component being so selected as to meter liquid being dispensed in drop form and avoid a stream of liquid from emerging from the dropper tip during normal use, said passageway being intersected by said membrane and communicating with both the liquophilic and liquophobic components.

2. A device according to claim 1 wherein and the pore size of the liquophoilic component of the membrane is from about 0.04 to about 0.65 μ

m.

3. A device according to claim 1 wherein the pore size of the liquophobic component of the membrane is from about 0.01 to about 0.45 μ

m.

4. A device according to claim 1 wherein the liquophilic component comprises from about 50 to about 70% of the surface area of the membrane.

5. A device according to claim 1 wherein the volume between the composite membrane and the dropper tip orifice is from about 0.001 to about 0.15 cm³.

6. A device according to claim 1 adapted to dispense an aqueous solution wherein the liquophobic component has a critical wetting surface tension of less than 35 dynes/cm.

7. A device according to claim 6 wherein the liquophilic component of the composite membrane has a critical wetting surface tension of at least 72 dynes/cm.

8. A device according to claim 6 wherein said aqueous solution includes a medicine.

9. A device according to claim 1 wherein the liquophilic component is made from a surface-modified microporous nylon polymer membrane.

10. A device according to claim 1 wherein the liquophobic component is made from a surface-modified microporous polyvinylidene fluoride membrane.

11. A device according to claim 1 wherein the container has elastically deformable sides.

12. A device according to claim 1 wherein the porosity of the composite microporous membrane is suitable for resisting the passage of bacterial contamination and the liquophilic component has a surface area of from about 20 mm² to about 90 mm².

13. A device according to claim 1 wherein said liquophilic component comprises a surface-modified microporous nylon membrane and said liquophobic component comprises a surface-modified microporous polyvinylidene fluoride membrane.

14. A device according to claim 1 wherein said liquophilic component comprises a surface-modified polyamide membrane having a CWST of at least about 50 dynes/cm and said liquophobic component comprises a surface-modified polyamide having a CWST of less than about 35 dynes/cm.

15. A device according to claim 14 wherein the CWST of said liquophilic component is at least about 72 dynes/cm and said liquophobic component is less than about 29 dynes/cm.

16. A device according to claim 1 wherein said orifice comprises a single orifice.

17. A device according to claim 1 wherein said liquophilic and liquophobic components are arranged in juxtaposed relationship.

18. A device according to claim 1 wherein the liquophilic component comprises a surface treated polyvinylidene fluoride membrane.

20. A device according to claim 1 wherein said liquophilic component comprises a surface-treated polyvinylidene fluoride membrane having a CWST of at least 50 dynes/cm and said liquophobic component comprises a polyvinylidene fluoride membrane having a CWST of less than about 75 dynes/cm.

19. A device according to claim wherein each of the liquophilic and liquiphobic components comprise polyvinylidene fluoride membranes.

21. A device for dispensing liquids in drop form of substantially uniform size which comprises an elastically deformable container having a dropper tip with a passageway therethrough for ingress of air to and egress of liquid from said device, said passageway terminating in an orifice and, disposed within the dropper tip and across the passageway, a composite microporous membrane with pore sizes less than 0.45 μ

m, said membrane comprising a hydrophilic component and a hydrophobic component, said hydrophilic component providing from about 60 to about 70% of the surface area of the composite membrane, said hydrophilic component having a surface area so selected as to meter liquid being dispensed in drop form and avoid a stream of liquid from emerging from the dropper tip during normal use, and said passageway being intersected by said membrane and communicating with both of said hydrophilic and hydrophobic components.

22. A device according to claim 21 wherein a composite microporous membrane has first and second components bonded together in side-by-side relationship, the first component having a surface area of from about 40 mm² to about 50 mm², an average pore size of from about 0.15 to about 0.25 μ

m, and a CWST of at least about 72 dynes/cm and being made from a surface-modified polyamide; and

the second component being made from a polyamide that has been surface-modified to produce a CWST of less than about 35 dynes/cm and having an average pore size of from about 0.1 to about 0.2 μ

m.

23. A device according to claim 22 wherein the volume between the orifice of the dropper and the surface of the composite membrane closest to the tip is from about 0.05 to about 0.1 cm³.

24. A device for dispensing liquids in drop form of substantially uniform size which comprises a container having a dropper tip including a passageway for ingress of air to and egress of liquid from said device, said passageway communicating between the container and an orifice in the dropper tip and, disposed within the dropper tip across the passageway, a microporous membrane with pores of a size to resist passage of contaminants, said membrane having a liquophilic component permitting delivery of drops of a liquid to a desired location outside the container, and a liquophobic component adapted to resist the passage of such liquid but to permit the passage therethrough of air, said passageway being intersected by said membrane and communicating with both of said liquophilic and liquophobic components, the surface area and pore size of the liquophilic component being selected so as to meter the liquid being dispensed in drop form and avoid a stream of liquid from emerging from the dropper tip during normal use.

25. A device according to claim 24 wherein the porosity of the microporous membrane is selected so as to resist the passage of bacterial contaminants and the surface area of the hydrophilic component is from about 20 mm² to about 90 mm².