Method and apparatus for preprogrammed infusion of IV medicaments

• US 5,219,330 A
• Filed: 11/26/1991
• Issued: 06/15/1993
• Est. Priority Date: 11/26/1991
• Status: Expired due to Term

• Current Assignee: Carefusion 303 Incorporated (Becton, Dickinson & Co)
• Original Assignee: IMED Corp (Becton, Dickinson & Co)
• Inventors: Bramble, Robert A., Firing, Eric L., Bollish, Stephen J.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): Maslione, C.
• Application Number:
  US07/798,937
• Time in Patent Office: 567 Days
• Field of Search: 128/DIG. 12, 128/DIG. 13, 604/53, 604/65, 604/67, 604/93, 604/131, 604/151-155, 604/246, 604/890.1, 604/891.1, 604/52
• US Class Current: 604/500
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: Y10S 128/12 Pressure infusion

Abstract

An apparatus for infusing TPN fluids to a patient includes a source of fluid, a pump for infusing fluid from the source to the patient, and a computer for controlling the operation of the pump. During the operation of the apparatus the infusion rate of the pump is varied according to an infusion regimen that is based on the volume of fluid to be infused and the time during which the fluid is to be infused. This regimen is characterized by a trifurcated ramp up region having interrelated incremental rates of infusion which transition the pump from a zero rate of infusion to a steady state rate of infusion. The infusion regimen is also characterized by a period of steady state infusion which follows the ramp up region, and a ramp down region in which the infusion rate is decremented from the steady state rate based on the remaining volume of fluid to be infused to the patient and the remaining time for infusing this remaining volume of fluid. Infusion rate changes in both the ramp up and ramp down regions is accomplished in steps. Depending on the calculated steady state infusion rate, the step sizes may be either 5 ml/hr or 1 ml/hr. The different time intervals between steps in the ramp up region are related to each other and to the total time for infusing fluids to the patient and the time intervals between steps in the ramp down region are controlled by the computer.

Claims

1. A system for infusing a fluid to a patient which comprises:

a fluid source;

means connected to said fluid source for pumping fluid from said fluid source to said patient;

programmable means connected to said pumping means for operating said pumping means in accordance with an infusion regimen, said infusion regimen having a flat steady state infusion rate with a ramp up change in infusion rate which includes an initial change in rate of infusion, an intermediate change in rate of infusion, and a final transitional change in rate of infusion to begin said regimen, and a controlled ramp down change in infusion rate to end said regimen; and

input means connected to said programmable means for profiling said infusion regimen to compatibly control said programmable means with input data including a total volume of said fluid to be infused and a total time for infusing said total volume of fluid.

2. A system as recited in claim 1 wherein said ramp up change in infusion rate and said ramp down change in infusion rate are accomplished in steps, said steps in said ramp up change in infusion rate being characterized by a step size increment which is held for a determinable time interval, and said steps in said ramp down change in infusion rate being characterized by a step size decrement which is held for a controlled time interval.

3. A system as recited in claim 2 wherein said time interval for steps in said initial and said transitional changes in rate of infusion are substantially equal to each other and are directly related to said time interval for steps in said intermediate change in rate of infusion.

4. A system as recited in claim 3 wherein said intermediate change in rate of infusion is directly related to said total time for infusing fluid to said patient.

5. A system as recited in claim 3 wherein said intermediate change in rate of infusion is directly related to a time certain.

6. A system as recited in claim 3 wherein said time intervals for steps in said initial and said transitional changes are approximately one and one half times longer in duration than said time intervals for steps in said intermediate change.

7. A system as recited in claim 2 wherein said step size increment in said ramp up change and said step size decrement in said ramp down change are established by said input data for volume to be infused, said step size being approximately equal to five milliliters per hour (5 ml/hr) when said steady state infusion rate exceeds a set value of 30 ml/hr and being approximately equal to one milliliter per hour (1 ml/hr) when said steady state infusion rate is equal to or lower than said set values.

8. A system as recited in claim 2 wherein said ramp up change in infusion rate begins at zero.

9. A system as recited in claim 2 wherein said ramp down infusion rate transitions from said steady state infusion rate to an infusion rate of approximately one milliliter per hour (1 ml/hr), and said system further comprises means for operating said pumping means at said infusion rate of approximately one milliliter per hour (1 ml/hr) after completion of said infusion regimen.

10. A system as recited in claim 9 wherein said programmable means further comprises:

means for monitoring said pumping means to determine an actual rate of infusion of fluids from said fluid source;

means for monitoring a remaining volume of fluid to be infused;

means for determining the time remaining for completion of said infusion regimen;

means for calculating an ideal infusion rate using information on said remaining volume to be infused and said time remaining for completion of said infusion regimen;

a comparator for determining the difference between said ideal infusion rate and said actual rate; and

means for implementing a step size decremental change in said infusion rate whenever said difference between said ideal infusion rate and said actual rate exceeds a predetermined value.

11. A system as recited in claim 10 wherein said predetermined value is equal to one half said step size.

12. A system as recited in claim 11 wherein said ramp up change in infusion rate begins at zero.

13. An apparatus for infusing fluids to a patient from a fluid source which comprises:

a pump connected with said fluid source to pump fluid therefrom; and

a computer, said computer being programmable to control said pump for infusion of fluids to said patient in accordance with a profiled infusion regimen, said regimen including a volume of fluid to be infused to the patient, a time for infusing said volume, and a ramp up infusion region having interrelated incremental rates of infusion which include an initial change in rate of infusion, an intermediate change in rate of infusion, and a final transitional change in rate of infusion which transition said pump from zero rate of infusion to a steady state rate of infusion.

14. An apparatus as recited in claim 13 wherein said profiled infusion regimen further includes a ramp down region controlled by said computer in which infusion rates are decremented from said steady state rate of infusion based on remaining volume of fluid to be infused to the patient and remaining time for infusing said remaining volume.

15. An apparatus as recited in claim 14 wherein said ramp up region and said ramp down region are accomplished in steps, said steps in said ramp up region being characterized by a step size increment which is held for a determinable time interval, and said steps in said ramp down region being characterized by a step size decrement which is held for a controlled time interval, and wherein said step size increment in said ramp up region and said step size decrement in said ramp down region are established by said profiled infusion regimen for volume to be infused, said step size being approximately equal to five milliliters per hour (5 ml/hr) when said steady state infusion rate exceeds a set value of 30 ml/hr and being approximately equal to one milliliter per hour (1 ml/hr) when said steady state infusion rate is equal to or lower than said set value.

16. An apparatus as recited in claim 15 wherein said time interval for steps in said initial and said transitional changes in said ramp up region are substantially equal to each other and are approximately one and one half times longer in duration than said time intervals for steps in said intermediate change and further wherein said time intervals for steps in said intermediate change in rate of infusion are directly related to said time for infusing said volume of fluid to said patient.

17. An apparatus as recited in claim 14 wherein said computer further comprises:

means for monitoring said pumping means to determine an actual rate of infusion of fluids from said fluid source;

means for monitoring said remaining volume of fluid to be infused to the patient;

means for determining the remaining amount of said time for infusing said volume of said fluid for completion of said infusion regimen;

means for calculating an ideal infusion rate using information on said remaining volume to be infused and said time remaining for completion of said infusion regimen;

a comparator for determining the difference between said ideal infusion rate and said actual rate; and

means for implementing a step size detrimental change in said infusion rate whenever said difference between said ideal infusion rate and said actual rate exceeds a predetermined value.

18. An apparatus as recited in claim 17 wherein said predetermined value is equal to one half said step size.

19. A method for administering total parenteral nutrition to a patient with a programmable pump in accordance with an infusion regimen based on a selected volume of fluid to be infused and a total time for infusion, which comprises the steps of:

selecting times in said infusion regimen for a ramp up region, a steady state region, and a ramp down region, each said region being established as a percentage of said total time for infusion;

inputing data to said pump for said volume to infused and said total time for infusion;

calculating a steady state infusion rate;

selecting a step size compatible with said steady state infusion rate for use as increments in said ramp up region and decrements in said ramp down region;

selecting different time intervals in said ramp up region, between said step size increments, to transition operation of said pump from a zero infusion rate to said steady state infusion rate;

maintaining said steady state infusion rate in said steady state region of operation;

entering said ramp down region with one said step size decrement in said rate of infusion;

calculating an ideal infusion rate during operation in said ramp down region;

comparing an actual infusion rate with said ideal infusion rate to determine a difference therebetween;

reducing said actual infusion rate by one step size decrement when said difference exceeds a certain value; and

operating said pump at a KVO rate after operation in said ramp down region is completed.

20. A method as recited in claim 19 wherein said ideal infusion rate is calculated during said ramp down operation using a remaining volume to be infused and a remaining time for infusing said volume.

21. A method as recited in claim 19 wherein said step size is five milliliters per hour (5 ml/hr) when said steady state infusion rate is greater than thirty milliliters per hour, and is one milliliter pr hour (1 ml/hr) when said steady state infusion rate is less than or equal to thirty milliliters per hour.