Assay cartridge

• US 5,219,526 A
• Filed: 05/27/1992
• Issued: 06/15/1993
• Est. Priority Date: 04/27/1990
• Status: Expired due to Fees

• Current Assignee: Behringwerke Aktiengesellschaft (Sanofi )
• Original Assignee: PB Diagnostic Systems, Inc. (Sanofi )
• Inventors: Long, Ernest W.
• Primary Examiner(s): WARDEN, JILL ALICE
• Application Number:
  US07/891,977
• Time in Patent Office: 384 Days
• Field of Search: 422/58, 422/63, 422/64, 422/102, 422/104
• US Class Current: 422/64
• CPC Class Codes: G01N 2035/00049 for loading/unloading a carousel
• CPC Class Codes: G01N 35/00029 provided with flat sample substrates, e.g. slides G01N35/028 takes precedence
• CPC Class Codes: G01N 35/1079 with means for piercing stoppers or septums

Abstract

An assay cartridge suitable for use with automated analytical instruments which include a conveyor such as a carousel. The cartridge is configured with ledges extending outwardly from sides thereof, preferably at the bottom of the cartridge. The conveyor includes berths for receiving the cartridges, each berth being formed as a depressed region within a top surface of the conveyor and bounded by a floor at the bottom of the berth and opposed sidewalls and an end wall extending upwardly from the floor. The sidewalls are preferably parallel to each other. An open end of the berth, opposite the end wall serves as a port through which the cartridge is inserted and extracted from the berth. Each of the sidewalls of the berth is provided with a shoulder which extends inwardly towards a center line of the berth, and upon insertion of the cartridge, extends over the ledges of the cartridge to serve as a guide. The guide includes grooves formed between the shoulders and the floor. Cantilevered tongues are formed in the cartridge ledges, on opposite sides of the cartridge, for interaction with the grooves, regions of the floor being recessed beneath the shoulders to form depressions for reception of the cantilevered tongues. The tongues are configured for interaction with the shoulders to force the tongues into the depressions for locking the cartridge into the berth. Ends of the depression are inclined to facilitate a lifting of the tongues out of the depression upon extraction of the cartridge from the berth.

Claims

1. A system for securing an assay cartridge to a cartridge carrier in combination with an assay cartridge and a cartridge carrier, said system including first engagement means disposed on said cartridge and second engagement means disposed on said cartridge carrier and operative with said first engagement means for securing said cartridge;

and wherein

said cartridge carrier comprises a berth for receiving said cartridge, said berth including opposed sidewalls;

said second engagement means comprises guide means disposed along at least a part of said sidewalls of said berth;

and said cartridge comprises;

a housing which includes opposed sidewalls;

assay means in said housing for receiving a sample fluid and for providing a detectable signal in response to a component of interest in said fluid; and

an aperture in said housing to permit a fluid to be provided to said assay means; and

said first engagement means comprises a ledge extending longitudinally from each said sidewall for engagement with said guide means and tongue means being formed as a part of each of said ledges and being cantilevered from said ledges, said tongue means being configured for mating with said guide means of said carrier for releasably securing said cartridge to said carrier.

2. A system according to claim 1 wherein

said berth further includes an end wall, a floor disposed at a bottom of said berth and being contiguous to said sidewalls of said berth and to said end wall of said berth, and a port opposite said end wall for entry of said cartridge into said berth;

said carrier is configured as a rotatable carousel;

said sidewalls of said cartridge are spaced apart a distance commensurate with a width of said berth;

said cartridge aperture opens toward a top surface of said cartridge; and

said ledges are located at the bottom of said sidewalls of said cartridge.

3. A system according to claim 2 wherein said second engagement means includes shoulders extending from each of said sidewalls of said berth towards a center of said berth, each of said shoulders defining a groove disposed between the shoulder and said floor, said grooves being part of said guide means.

4. A system according to claim 3 wherein said second engagement means further comprises a depression formed in said floor of said berth beneath each of said shoulders;

and

each of said tongue means including a tongue configured for interaction with a corresponding one of the shoulders of said second engagement means for entering into a corresponding one of said depressions for locking said cartridge in said berth with a front of said cartridge abutting said end wall of said berth.