Heat-activated drug delivery system and thermal actuators therefor

• US 5,222,362 A
• Filed: 05/15/1990
• Issued: 06/29/1993
• Est. Priority Date: 01/10/1989
• Status: Expired due to Term

• Current Assignee: Baylor College of Medicine (Baylor College)
• Original Assignee: Daryl D. Maus, Scott F. Tibbitts
• Inventors: Tibbitts, Scott F., Maus, Daryl D.
• Primary Examiner(s): Ostrager, Allen M.
• Application Number:
  US07/524,218
• Time in Patent Office: 1,141 Days
• Field of Search: 60/527, 60/530, 60/531
• US Class Current: 60/527
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3613 by body heat
• CPC Class Codes: A61M 2205/3653 by Joule effect, i.e. electric resistance
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/145 using pressurised reservoirs, e.g. pressurised by means of pistons
• CPC Class Codes: A61M 5/14526 the piston being actuated by fluid pressure
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: F03G 7/06 using expansion or contraction of bodies due to heating, cooling, moistening, drying or the like using thermal expansion of non-vaporising liquids F01K

Abstract

A thermal actuator, also known as a heat capacitance motor, derives its energy from the physical expansion of paraffin wax as it changes from solid to liquid when heated within an enclosure such as a cylinder. This energy is converted into mechanical force which causes translation of a piston slidably mounted within the cylinder, thus creating hydrostatic pressure which is converted to work. The thermal actuator may be utilized in various drug delivery systems in which the hydrostatic pressure created by the actuator is used expel the contents of a syringe.

Claims

1. A thermal actuator for producing mechanical motion from temperature changes, said thermal actuator comprising:

a) an actuator body defining a chamber;

b) a force-transmitting elastomeric component disposed in said chamber, said elastomeric component being closed at one end and having a central bore of predetermined diameter through the opposite end, said elastomeric component having a wall of predetermined thickness and of a predetermined durometer rating, said actuator body including an annular wall encircling said elastomeric component in spaced relation thereto;

c) an actuation rod reciprocally received in said bore, said actuation rod having

i) a cylindrical surface,

ii) a first end spaced from said closed end of said elastomeric component,

iii) a second end projecting through said opposite end of said elastomeric component, and

iv) a predetermined diameter substantially less than the predetermined diameter of said bore, thus creating an annular space of predetermined size between said rod and said elastomeric component;

d) a thermally responsive expansion material contained between said elastomeric component and said encircling wall; and

e) a lubricant contained in said annular space between said rod and said elastomeric component;

wherein said durometer rating, said wall thickness, and the size of said annular space are selected such that when said thermally responsive expansion material exerts sufficient hydraulic pressure on said elastomeric component, the portion of said elastomeric component between said closed end and said first end of said rod collapses inwardly to create an axial force on said first end of said rod while the remaining portion of said elastomeric component folds along a diameter to make surface contact with the cylindrical surface of said rod along diametrically opposed arcs, leaving at least one non-contact area between said arcs, said non-contact area defining a space for retaining lubricant along the length of said rod.

2. The thermal actuator of claim 1, in which the geometry of said end portion of said rod and of said elastomeric component when creased are selected to create a pocket of lubricant which follows the movement of said rod end.

3. The thermal actuator of claim 1, in which the geometry of said end portion of said rod and of said elastomeric component are selected to create a reservoir of lubricant at the closed end of said elastomeric component, said reservoir slowly shrinking due to compression set, thereby releasing said lubricant over time.

4. The thermal actuator of claim 1, in which said elastomeric component is tapered such that the diameter of the closed end is at least as great as the diameter of the open end.

5. The thermal actuator of claim 1, in which said force-transmitting elastomeric component is formed of a high performance urethane.

6. The thermal actuator of claim 1, wherein said elastomeric component comprises an upper portion disposed within said chamber and immersed in said expansion material, said upper portion including an annular wiper ring extending radially inwardly in said bore to center said actuator rod within said bore, said wiper ring sealingly engaging said rod with increasing tightness in response to increasing pressure from said expansion material, thus retaining said lubricant and preventing intrusion of outside material up to a predetermined failure pressure.

7. The thermal actuator of claim 6, wherein said annular wiper ring is integrally molded with said elastomeric component.