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Method for immobilizing a polypeptide in a polymer and a membrane produced thereby

  • US 5,223,124 A
  • Filed: 09/05/1990
  • Issued: 06/29/1993
  • Est. Priority Date: 02/05/1988
  • Status: Expired due to Term
First Claim
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1. A method for producing a polyurethane membrane comprising an immobilized peptide, said method comprising:

  • a) adding (i) said polypeptide and (ii) a permeability modifying agent selected from the group consisting of heparin, alginic acid and albumin to an aqueous polyurethane dispersion wherein said polypeptide is dissolved;

    b) shaping said aqueous dispersion into a membrane;

    c) drying said polyurethane membrane whereby said polypeptide is entrapped in the polyurethane without any covalent bonding between the polypeptide and the polyurethane; and

    d) optionally subjecting said dried polyurethane membrane to a heat treatment at a temperature of from about 40°

    C. to about 80°

    C. for a period of time of from about 30 minutes to about 30 hours.

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