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Microreservoir liposome composition and method

  • US 5,225,212 A
  • Filed: 12/10/1990
  • Issued: 07/06/1993
  • Est. Priority Date: 10/20/1989
  • Status: Expired due to Term
First Claim
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1. A liposome composition effective to extend, to at least 24 hours, the period of effective activity of a therapeutic compound which can be administered intravenously in a therapeutically effective amount and which is cleared in free form from the bloodstream with a halflife of less than about 4 hours, comprisingliposomes (i) composed of vesicle-forming lipids and between 1-20 mole percent of a vesicle-forming lipid derivatized with a polymer selected from the group consisting of polyethyleneglycol, polyacetic acid and polyglycolic acid, and (ii) having a selected mean particle diameter in the size range between about 0.1 to 0.4 microns, andthe compound in liposome-entrapped form,for intravenous administration at a dose of the composition which contains an amount of the compound in liposome-entrapped form which is at least three times such therapeutically effective amount.

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