Composite anesthetic article and method of use
First Claim
1. The method for preparing an aqueous solution of a buffered parenteral anesthetic, said solution having a pH of from about 7.0 to about 8.5 and ready for immediate injection into the human body at the time of medical procedure, said method comprising providing a first vial containing a dilute aqueous acid buffering system containing essentially electrolyte-free water and sodium bicarbonate, providing a second vial containing a parenteral anesthetic having in non-buffered form a pH of below 7.0, each of said vials having a closure cap thereon hermetically sealing the same, and each said cap having a portion which is readily penetrable by the needle of a syringe, inserting said needle through said cap portion of said first vial into said buffering system and withdrawing the same into said syringe, and inserting said needle through said cap portion of said second vial and injecting said buffering system into said second vial to contact said anesthetic and buffer the same to a pH of above 7.0.
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Accused Products
Abstract
An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing sufficient NaHCO3 to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO2 per ml of composition up to the saturation level of dissolved CO2 at a CO2 head pressure of up to about 2.5 atmospheres.
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Citations
9 Claims
- 1. The method for preparing an aqueous solution of a buffered parenteral anesthetic, said solution having a pH of from about 7.0 to about 8.5 and ready for immediate injection into the human body at the time of medical procedure, said method comprising providing a first vial containing a dilute aqueous acid buffering system containing essentially electrolyte-free water and sodium bicarbonate, providing a second vial containing a parenteral anesthetic having in non-buffered form a pH of below 7.0, each of said vials having a closure cap thereon hermetically sealing the same, and each said cap having a portion which is readily penetrable by the needle of a syringe, inserting said needle through said cap portion of said first vial into said buffering system and withdrawing the same into said syringe, and inserting said needle through said cap portion of said second vial and injecting said buffering system into said second vial to contact said anesthetic and buffer the same to a pH of above 7.0.
Specification