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Liposphere delivery systems for local anesthetics

  • US 5,227,165 A
  • Filed: 01/22/1992
  • Issued: 07/13/1993
  • Est. Priority Date: 11/13/1989
  • Status: Expired due to Term
First Claim
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1. A liposphere comprising:

  • a core formed of a hydrophobic material existing as a solid at a temperature of 30°

    C. having anesthetic activity as a result of an anesthetic compound, anda phospholipid coating surrounding the core, wherein the hydrophobic ends of the phospholipid are embedded in the solid core and the hydrophilic ends of the phospholipid are exposed on the surface of the liposphere,the combination forming a spherical structure having an average particle diameter between 0.35 and 250 microns,wherein the core may contain a vehicle for the anesthetic compound, and the anesthetic compound, vehicle, and phospholipid coating are in a ratio of anesthetic compound to vehicle to phospholipid between 1;

    0;

    0.01 and 1;

    100;

    100.

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