Measuring the change of intravascular blood volume during blood filtration

• US 5,230,341 A
• Filed: 02/25/1991
• Issued: 07/27/1993
• Est. Priority Date: 08/13/1988
• Status: Expired due to Term

• Current Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Original Assignee: Fresenius AG (Fresenius SE & Co. KGaA)
• Inventors: Polaschegg, Hans-Dietrich
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US07/660,240
• Time in Patent Office: 883 Days
• Field of Search: 128/668, 128/691, 604/4-6, 604/27, 604/29-31, 604/65, 604/251, 604/253, 604/255
• US Class Current: 600/481
• CPC Class Codes: A61M 1/16 with membranes
• CPC Class Codes: A61M 1/1605 Physical characteristics of the dialysate fluid
• CPC Class Codes: A61M 1/361 before treatment
• CPC Class Codes: A61M 1/3612 after treatment
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/3324 PH measuring means
• CPC Class Codes: A61M 2205/3368 Temperature
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2230/207 hematocrit

Abstract

To determine in simple manner the change of the intravascular blood volume during filtration, in the extracorporeal blood circuit (2) of a blood purification apparatus at least one ultrasonic sensor (15) is arranged which is connected to an evaluating unit (18) which is configured in such a manner that at the start of the filtration a first ultrasonic signal is stored and during the filtration the change of the ultrasonic signals is determined. From the change of the ultrasonic signals the change of the hematocrit is determined and from this the change of the intravascular blood volume is deduced.

Claims

1. Apparatus for measuring the change in intravascular blood volume occurring during a blood filtration procedure by measuring the change of the hematocrit of the blood, said apparatus being adapted for use with a blood purification device in which the filtration procedure is carried out and which has an extracorporeal blood circuit connected to a patient, said apparatus comprising:

a measuring device comprising ultrasonic sensor means adapted to be connected to the extracorporeal blood circuit of the device for ultrasonically examining the blood flowing in the circuit and for providing a signal indicative of the hematocritic properties thereof; and

an evaluating unit coupled to said sensor means, said evaluating unit including means for receiving the signal from said ultrasonic sensor means, said evaluating unit including means for storing a signal from said ultrasonic sensor means obtained at the start of the blood filtration procedure, and said evaluating unit including means for determining the change in the signal from said ultrasonic sensor means occurring during the blood filtration procedure for determining the change in the hematocrit of the blood and thus the change in the intravascular blood volume.

2. The apparatus according to claim 1 wherein the extracorporeal blood circuit of the blood purification device has an arterial part for withdrawing blood from the patient and a venous part for returning blood to the patient and wherein said ultrasonic sensor means is further defined as means adapted to be connected to the arterial part of the extracorporeal blood circuit for ultrasonically examining the blood flowing in the arterial part of the extracorporeal blood circuit.

3. The apparatus according to claim 2 wherein said ultrasonic sensor means comprises first and second ultrasonic sensors, wherein said first ultrasonic sensor is adapted to be connected in the arterial part of the extracorporeal blood circuit for ultrasonically examining the blood flowing in the arterial part of the extracorporeal blood circuit, said first ultrasonic sensor being coupled to said evaluating unit for providing a signal indicative of the hematocritic properties of the blood flowing in the arterial part of the circuit to the evaluating unit, wherein said second ultrasonic sensor is adapted to be connected in the venous part of the extracorporeal blood circuit for ultrasonically examining the blood flowing in the venous part of the extracorporeal blood circuit, said second ultrasonic sensor being coupled to said evaluating unit for providing a signal indicative of the hematocritic properties of the blood flowing in the venous part of the circuit to the evaluating unit, and wherein said evaluating unit is further defined as including means for determining the relative change in the signals received from said first ultrasonic sensor and said second ultrasonic sensor occurring during a blood filtration procedure for determining the relative change of the hematocrit of the blood and thus the relative change in intravascular blood volume.

4. The apparatus according to claim 1 further including a temperature measuring device adapted to be connected to the extracorporeal blood circuit and coupled to said evaluating unit, said evaluating unit including means for correcting the determination of the hematocrit of the blood for temperature changes.

5. The apparatus according to claim 4 including a plurality of temperature measuring devices adapted to be connected to the extracorporeal blood circuit and coupled to said evaluating unit.

6. The apparatus according to claim 1 wherein the blood purification apparatus has a control unit for controlling the filtration procedure and wherein said evaluating unit is further defined as adapted to be connected to said control unit for providing an input signal thereto.

7. The apparatus according to claim 1 further including means for detecting air in the extracorporeal blood circuit, said air detecting means being connected to said evaluating unit.

8. The apparatus according to claim 1 wherein the extracorporeal blood circuit of the blood purification device has a drip chamber and wherein said ultrasonic sensor means is adapted to be connected to the drip chamber for providing a signal indicative of liquid levels in the drip chamber, said evaluating unit including means responsive to the liquid levels signal for determining liquid levels in the drip chamber.

9. The apparatus according to claim 1 wherein said apparatus further including a Doppler blood flow measuring device adapted to be connected to the extracorporeal blood circuit for measuring the flow properties of the blood in the extracorporeal blood circuit and for providing a signal in accordance therewith, said measuring device being coupled to said evaluating unit.