Method of monitoring blood loss
First Claim
1. A method for monitoring a mammalian patient'"'"'s blood loss during a surgical operation on said patient comprising the steps of:
- determining the hemoglobin concentration i the blood of said patient immediately prior to said operation,collecting all blood-bearing materials generated during said operation,adding said materials to an eluent comprised of a buffer and a volume control substance selected from the group consisting of Li+, SCN- and Br- in a known concentration, said buffer being hypnotic to red blood cells in said materials, such that said red blood cells undergo osmotic hemolysis,subjecting said eluent containing said materials to ultrasonic vibration in order to release blood from solid materials added to said eluent, thereby providing a blood-containing buffered solution,determining hemoglobin concentration in said blood-containing buffered solution after said ultrasonic vibration has released blood from said materials,determining the concentration of said volume control substance in said buffered solution and obtaining thereby the volume of said buffered solution after the foregoing steps have been performed, and calculating the actual amount of blood lost in said patient by multiplying he hemoglobin concentration in said blood-containing buffered solution by the volume of said buffered solution after said steps have been performed, and adjusting that value on the basis of hemoglobin concentration in the blood of said patient determined immediately prior to said operation.
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Abstract
Blood loss by a patient during an operation is monitored by collecting all blood and bloodied materials generated during the operation and subjecting them to ultrasonic vibration in a buffered eluent containing a volume control substance by which the actual volume of the blood-added eluent can be determined. Hemoglobin concentration in the eluate is measured periodically or continually, and multiplied by the eluate volume, to give the actual hemoglobin lost. This value is adjusted by the hemoglobin concentration of the patient just prior to the operation, to give the actual blood volume lost. The blood lost during the operation can also be monitored continuously, and real time values provided.
48 Citations
11 Claims
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1. A method for monitoring a mammalian patient'"'"'s blood loss during a surgical operation on said patient comprising the steps of:
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determining the hemoglobin concentration i the blood of said patient immediately prior to said operation, collecting all blood-bearing materials generated during said operation, adding said materials to an eluent comprised of a buffer and a volume control substance selected from the group consisting of Li+, SCN- and Br- in a known concentration, said buffer being hypnotic to red blood cells in said materials, such that said red blood cells undergo osmotic hemolysis, subjecting said eluent containing said materials to ultrasonic vibration in order to release blood from solid materials added to said eluent, thereby providing a blood-containing buffered solution, determining hemoglobin concentration in said blood-containing buffered solution after said ultrasonic vibration has released blood from said materials, determining the concentration of said volume control substance in said buffered solution and obtaining thereby the volume of said buffered solution after the foregoing steps have been performed, and calculating the actual amount of blood lost in said patient by multiplying he hemoglobin concentration in said blood-containing buffered solution by the volume of said buffered solution after said steps have been performed, and adjusting that value on the basis of hemoglobin concentration in the blood of said patient determined immediately prior to said operation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification