Agent gas analyzer and method of use

• US 5,231,591 A
• Filed: 07/05/1991
• Issued: 07/27/1993
• Est. Priority Date: 09/11/1989
• Status: Expired due to Fees

• Current Assignee: Nellcor Puritan Bennett Incorporated (Medtronic Plc)
• Original Assignee: Nellcor Incorporated (Medtronic Plc)
• Inventors: Ferus, Lucille A., Breton, Keith H., Flewelling, Ross F., Johansson, Eric T., Culver, John A.
• Primary Examiner(s): Teska, Kevin J.
• Application Number:
  US07/726,430
• Time in Patent Office: 753 Days
• Field of Search: 364/413.02, 364/413.03, 364/496-499, 250/338, 250/339, 250/343, 250/344, 250/345, 356/51, 356/437, 128/719, 422/83
• US Class Current: 702/24
• CPC Class Codes: A61B 5/083 Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
• CPC Class Codes: A61M 16/085 Gas sampling
• CPC Class Codes: A61M 16/104 specially adapted for anaesthetics A61M16/18 takes precedence
• CPC Class Codes: A61M 2016/102 Measuring a parameter of the content of the delivered gas
• CPC Class Codes: A61M 2016/1035 the anaesthetic agent concentration
• CPC Class Codes: G01N 2021/3129 Determining multicomponents by multiwavelength light
• CPC Class Codes: G01N 21/3504 for analysing gases, e.g. multi-gas analysis

Abstract

An agent gas analyzer that will determine the types and measure simultaneously the concentrations of a plurality of agent gases in a respiratory gas stream of an anesthetized patient, with the analyzer self-determining the agent gas types and concentrations each time gas measurements are made.

Claims

1. An agent gas analyzer for simultaneously determining concentrations of N gases in a respiratory gas stream, where N>

1, said agent gas analyzer comprising;

an optical bench including

at least one light source mounted to irradiate a portion of said respiratory gas stream with radiation,

means for separating said radiation into N different bands of wavelengths of said radiation, and

means for detecting the amount of radiation received, after passing through said portion of said respiratory gas stream, in each of said N different bands of wavelengths of said radiation;

means, coupled to said optical bench, for generating N electrical absorption signals representative of said amount of received radiation in said N bands; and

means, coupled to said means for generating, for computing simultaneously the concentrations of each of said N gases in the respiratory gas stream using matrix equations with a dimension of the matrix equal to N, and including said N electrical absorption signals as variables which are at least second order variables in said matrix equations.

2. The apparatus as recited in claim 1, wherein said at least second order variables include third order variables.

3. The apparatus of claim 1 further comprising:

a memory storing coefficients for said matrix equation, said coefficients varying according to the values of said electrical absorption signals; and

means for applying said electrical absorption signals to said memory to select a set of coefficients for use in said matrix equation.

4. The apparatus of claim 1 wherein said means for separating includes:

N filters having N discrete passbands of radiation wavelengths for selectively filtering radiation produced by said light source.

5. The apparatus of claim 1 wherein said means for computing determines said amount of radiation absorbed during periods when a rate of change of a reference gas in said respiratory gas stream is within a predetermined range and interpolates a value from values for absorption in one of said bands from previous and subsequent periods based on a time-weighted average when the amount of radiation absorbed in said one band is not detected in one of said periods.

6. The apparatus of claim 1 further comprising:

means for detecting the absorption of radiation in a reference band corresponding to absorption by a reference gas indicative of inspired and expired events in a breath cycle of said respiratory gas stream;

wherein said means for computing determines the occurrence of an inspired or expired event from the amount of radiation detected in said reference band and computes and displays said concentrations for a period of time corresponding to one of said inspired and expired events.

7. The apparatus of claim 6 wherein said reference gas is carbon dioxide.

8. The apparatus of claim 6 wherein said means for computing determines a sample period within one of said inspired and expired periods wherein the rate of change of absorption by said reference gas is within a predetermined range and computes the concentrations of each of said N gases from said amount of radiation detected during said sample period of time.

9. The apparatus of claim 6 wherein said means for determining the occurrence of an inspired or expired event includes means for determining whether the absorption in said reference band for said inspired and expired events crossed inspired and expired threshold levels, respectively.

10. The apparatus of claim 9 wherein said inspired and expired threshold levels are continually adjusted based upon both previous inspired and expired events.

11. An agent gas analyzer for determining concentrations of N agent gases in a respiratory gas stream, said agent gas analyzer comprising:

an optical bench including

at least one light source mounted to irradiate a portion of said respiratory gas stream with radiation,

means for separating said radiation into a reference band, corresponding to absorption by a reference gas indicative of inspired and expired events in a breath cycle of said respiratory gas stream, and N different agent bands of wavelengths of said radiation, and

means for detecting the absorption of radiation from radiation received, after passing through said portion of said respiratory gas stream, in said reference band;

means, coupled to said optical bench, for determining the occurrence of an inspired or expired event from the amount of received radiation detected in said reference band;

means for detecting the amount of radiation absorbed by said respiratory gas stream in said N different agent bands; and

means for computing and displaying said concentrations from said amounts of radiation in said agent bands absorbed for a period of time corresponding to one of said inspired and expired events wherein the rate of change of absorption by said reference gas is within a predetermined range.

12. An agent gas analyzer for determining concentrations of N gases in a respiratory gas stream, said agent gas analyzer comprising:

an optical bench including

at least one light source mounted to irradiate a portion of said respiratory gas stream with radiation,

means for separating said radiation into N different bands of wavelengths of said radiation, and

means for detecting the absorption of radiation from radiation received, after passing through said portion of said respiratory gas stream, in as many of said N bands of wavelengths of said radiation as is possible during each of a plurality of measurement periods;

means, coupled to said optical bench, for interpolating a value from values for absorption in one of said bands from previous and subsequent periods to determine the absorption in said one band when absorption is not detected in one of said measurement periods and computing the concentrations of each of said N gases using detected and interpolated absorptions with multiple simultaneous equations.

13. The apparatus of claim 12 wherein said measurement period is one of an inspired and expired event in a breath cycle.

14. The apparatus of claim 12 wherein said multiple simultaneous equations are matrix equations with said absorptions being variables which are at least second order variables.

15. An agent gas analyzer for determining concentrations of N gases in a respiratory gas stream, where N>

1, said agent gas analyzer comprising;

an optical bench including

at least one light source mounted to irradiate a portion of said respiratory gas stream with radiation,

means for separating said radiation into N different bands of wavelengths of said radiation, and

means for detecting the absorption of said radiation from radiation received, after passing through said portion of said respiratory gas stream, in said N bands of wavelengths of said radiation;

means, coupled to said optical bench, for comparing a detected absorption in one of said N bands to criteria for one of an inspired and an expired event of a breath cycle;

means for determining whether said absorption for said one band is within said event; and

means for computing the concentrations of each of said N gases during said event using detected absorptions with multiple simultaneous equations.

16. The apparatus of claim 15 wherein said means for detecting includes means for moving a filter for one of said N bands through said respiratory gas stream, such that said moving is synchronized with said event.

17. The apparatus of claim 15 wherein said criteria include determining whether the absorption levels for a reference gas cross threshold levels for inspired and expired events of a breath cycle.

18. The apparatus of claim 15 wherein said criteria include a predetermined range for a rate of change of said one band.

19. The apparatus of claim 18 wherein said one band corresponds to a reference gas.

20. The apparatus of claim 18 wherein said one band corresponds to an agent gas.

21. The apparatus of claim 18 wherein said multiple simultaneous equations are matrix equations with said absorptions being variables which are at least second order variables.