Cardiac pacemaker with operational amplifier output circuit

• US 5,233,985 A
• Filed: 07/15/1991
• Issued: 08/10/1993
• Est. Priority Date: 08/10/1990
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Hudrlik, Terrence R.
• Primary Examiner(s): Kamm, William E.
• Application Number:
  US07/730,160
• Time in Patent Office: 757 Days
• Field of Search: 128/419
• US Class Current: 607/27
• CPC Class Codes: A61N 1/37 Monitoring; Protecting
• CPC Class Codes: A61N 1/3704 Circuits specially adapted therefor, e.g. for sensitivity control
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371
• CPC Class Codes: A61N 1/371 Capture, i.e. successful stimulation

Abstract

A medical electrical stimulator employing an operational amplifier output circuit for producing an electrical stimulating pulse for application to body tissue and for sensing electrical activity in the body tissue. A first input to the operational amplifier is coupled through a virtual load to a probe electrode in close proximity to the body tissue. The second input is coupled to a second electrode which may be remote from the tissue to be stimulated. A defined voltage signal may be provided to the second input to the amplifier, and the amplifier correspondingly delivers current through the virtual load to the probe electrode as the amplifier maintains equal voltage levels at its two inputs. The current delivered to the probe electrode functions to stimulate the body tissue. By varying the defined voltage signals provided to the second input of the amplifier, arbitrary stimulation pulse waveforms may be generated. After termination of the defined voltage signal, the amplifier functions to restore the electrode/tissue system to its previous electrical equilibrium condition and to sense induced or spontaneous electrical activity in the tissue. The circuit may be employed in cardiac pacemakers, with the probe electrode located on or in the heart, or in other electrical medical stimulators.

Claims

1. A stimulation pulse generator apparatus for a medical electrical stimulator, comprising:

an operational amplifier having an amplifier output and having first and second amplifier inputs;

first electrode electrically coupled to said first input of said amplifier;

a virtual load electrically coupled between said first electrode and said first input of said amplifier;

a second electrode coupled to said second input of said amplifier; and

voltage source means for providing defined pulsatile voltage waveforms to said second input of said amplifier to cause corresponding delivery of voltage pulses to said first electrode.

5. The apparatus of claim 1 or claim 2 or claim 3 or claim 4 wherein said first electrode is adapted for implantation on or in the heart and wherein said first electrode has a surface area of 5 square millimeters or less, and wherein said virtual load has a resistance of 1,000 ohms or less.

2. A medical electrical stimulator apparatus, comprising:

a timing circuit for triggering the generation of stimulation pulses; and

a pulse generator triggered by said timing circuit to generate stimulation pulses, said pulse generator comprising an operational amplifier having an amplifier output and having first and second amplifier inputs;

a first electrode electrically coupled to said first input of said amplifier;

a virtual load electrically coupled between said first electrode and said first input of said amplifier;

second input of said amplifier; and

voltage source means for providing defined pulsatile voltage waveforms to said second input of said amplifier to cause corresponding delivery of voltage pulses to said first electrode.

3. A cardiac pacer apparatus, comprising:

a resettable timing circuit for triggering the generation of stimulation pulses;

a pulse generator triggered by said timing circuit to generate stimulation pulses, said pulse generator comprising an operational amplifier having an amplifier output for providing electrical signals and having first and second amplifier inputs;

a first electrode electrically coupled to said first input of said amplifier;

a virtual load electrically coupled between said first electrode and said first input of said amplifier;

a second electrode electrically coupled to said second input of said amplifier; and

voltage means for providing defined pulsatile voltage waveforms to said second input of said amplifier to cause corresponding delivery of voltage pulses to said first electrode; and

means for detecting a heart depolarization and for resetting said timing circuit in response to detection of a said depolarization, said detecting means responsive to electrical signals provided by said output of said operational amplifier.

4. An apparatus according to claim 3 wherein said detecting means comprises means for defining a capture detection time interval following provision of a said pulsatile voltage waveform to said second input of said operational amplifier and means responsive to detection of a said depolarization occurring during said capture detection time interval for indicating that the said corresponding voltage pulse delivered to said probe electrode was successful in stimulating a heart depolarization.

6. Apparatus for detecting and stimulating depolarization of cardiac tissue, comprising:

an active circuit having first and second inputs and an output and having means for maintaining said first and second inputs at the same voltage;

a first electrode;

a virtual load coupled between said first electrode and said first input;

a second electrode coupled to said second input; and

voltage source means for providing pulsatile voltage signals having defined waveforms to said second input;

wherein said maintaining means comprises means for maintaining said first and second inputs at the same voltage by delivering electrical energy through said virtual load and said first electrode and wherein said output of said active circuit provides a signal indicative of the electrical energy delivered through said virtual load.

10. The apparatus of claim 6 or claim 7 or claim 8 or claim 9 wherein said first electrode is adapted for implantation on or in the heart.

11. The apparatus of claim 10 wherein said first electrode has a surface area of 5 square millimeters or less, and wherein said virtual load has a resistance of 1,000 ohms or less.

12. The apparatus of claim 6 or claim 7 or claim 8 or claim 9 wherein said active circuit comprises an operational amplifier.

7. Apparatus for stimulating tissue, comprising:

an active circuit having first and second inputs and an output and having means for maintaining said first and second inputs at the same voltage;

a first electrode;

a virtual load coupled between said first electrode and said first input;

a second electrode coupled to said second input; and

voltage source means for providing pulsatile voltage signals having defined waveforms to said second input;

wherein said maintaining means comprises means for maintaining said first and second inputs at the same voltage by delivering electrical energy through said virtual load and said first electrode, whereby a voltage pulse is delivered to said first electrode in response to the provision of a pulsatile voltage signal by said voltage source means.

8. The apparatus of claim 7 wherein said active circuit comprises monitoring circuitry responsive to the electrical energy delivered through said virtual load and providing said output signal in response to a said delivered energy meeting predetermined criteria.

9. The apparatus of claim 8 wherein said monitoring circuitry comprises means for defining a capture detection time interval following provision of a said pulsatile voltage signal to said second input of said active circuit and means responsive to said output signal occurring during said capture detection time interval for indicating that the said voltage pulse delivered to said probe electrode was successful in stimulating said tissue.