Method for increasing feed efficiency in animals

• US 5,234,694 A
• Filed: 09/02/1992
• Issued: 08/10/1993
• Est. Priority Date: 07/11/1990
• Status: Expired due to Term

• Current Assignee: ALZA Corporation (Johnson & Johnson)
• Original Assignee: ALZA Corporation (Johnson & Johnson)
• Inventors: Magruder, Judy A., Eckenhoff, James B., Peery, John R.
• Primary Examiner(s): Page, Thurman K.
• Assistant Examiner(s): BROUILLETTE, D GABRIELLE
• Application Number:
  US07/939,263
• Time in Patent Office: 342 Days
• Field of Search: 424/473
• US Class Current: 424/473
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

This invention relates to an active agent delivery device. More particularly, the invention relates to a delivery device that includes a sleeve to protect the delivery device from transient mechanical forces. The delivery device of the invention is robust and resistant to transient mechanical forces. The invention provides a fluid-imbibing delivery device comprising a housing enclosing an internal compartment, said housing having a first wall section that substantially restricts the passage of fluid into the delivery device, i.e. is substantially fluid-impermeable, and that contains a beneficial agent; a second wall section that permits the passage of fluid into the delivery device, i.e. is fluid-permeable, and that contains at least one expandable driving member; and exit means; with a protective sleeve means extending from the first wall section of the housing to cover and protect the second wall section of the housing and the junction of the first and second sections. The protective sleeve is preferably configured to provide substantially no resistance to flow of fluid or fluid vapor through the fluid-permeable second wall section.

Claims

1. A method for increasing the feed conversion efficiency of a hog, wherein the method comprises:

(1) admitting into the hog a dispenser comprising;

(a) a first wall section comprising a wall that surrounds an internal compartment and an open end, the wall comprising a composition that is substantially impermeable to the passage of fluid;

(b) a second wall section comprising a wall that surrounds an internal compartment and an open end, the wall comprising a composition permeable to the passage of fluid, wherein the open end of the first wall section and the open end of the second wall section are in mated contact;

(c) a rigid sleeve extending from the first wall section to cover the junction of the first wall section and the second wall section and to at least partially cover the sides of the second wall section, the inside diameter of the sleeve being greater than the outside diameter of the second wall section, and the sleeve being able to resist transient mechanical forces of at least about 2 kilograms force;

(d) a porcine somatotropin for increasing feed conversion efficiency in the compartment comprising the first wall section;

(e) at least one expandable driving member in the compartment comprising the second wall section for pushing the porcine somatotropin from the dispenser; and

(f) at least one exit passageway for delivering the porcine somatotropin from the dispenser;

(2) allowing fluid to be imbibed through the permeable second wall section of the dispenser for causing the expandable driving member or members to increase in volume; and

(3) delivery the porcine somatotropin to the hog by the driving member or members increasing in volume, thereby pushing the porcine somatotropin through the exit passageway to the hog at a controlled rate over a prolonged period of time for increasing the feed conversion of the hog.

2. A method according to claim 1 wherein the sleeve resists transient mechanical forces of about 6 kilograms force.

3. A method according to claim 1 wherein the sleeve has a minimum tensile strength of about 9000 psi.

4. A method according to claim 1 wherein the sleeve completely covers the sides of the second wall section and extends to or below the rear end of the second wall section.