Precalibrated fiber optic sensing method

• US 5,234,835 A
• Filed: 09/26/1991
• Issued: 08/10/1993
• Est. Priority Date: 09/26/1991
• Status: Expired due to Fees

• Current Assignee: C.R. Bard, Inc. (Becton Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton Dickinson & Co)
• Inventors: Hauenstein, Bennett L., Nestor, James R.
• Primary Examiner(s): Johnston, Jill A.
• Application Number:
  US07/766,021
• Time in Patent Office: 684 Days
• Field of Search: 436/8, 436/11, 436/172, 422/1, 422/82.06-82.09, 128/634, 128/633
• US Class Current: 436/11
• CPC Class Codes: A61B 2562/085 combined with means for recording calibration data
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/102499 Blood gas standard or control

Abstract

A precalibrated sensing system for determining a blood parameter such as the partial pressures of oxygen (pO₂) and carbon dioxide (pCO₂), and the negative logarithm of hydrogen ion activity (pH). A dry sensor is provided which may be calibrated in the factory, packaged, sterilized and stored, without requiring recalibration prior to use.

Claims

1. A method of providing a precalibrated optical sensing system for sensing a parameter of blood, comprising the steps of:

providing a stable optical sensor in solid form for sensing a parameter of blood;

determining an associated set of calibration data for the sensor by exposing the sensor to at least one calibration medium, measuring the optical response of the sensor to the medium and determining the associated calibration data based on the response, and then removing the sensor from the calibration medium;

recording the calibration data; and

sterilizing the sensor following calibration;

wherein the sensor may be stored at least 24 hours outside of any calibration medium and used along with recorded calibration data to sense a blood parameter without requiring recalibration prior to use.

3. The method of claim 1, wherein the sensor is used to sense a parameter selected from the group consisting of oxygen, carbon dioxide and pH.

4. The method of claim 1, wherein multiple sensors are provided to sense different parameters selected from the group consisting of oxygen, carbon dioxide and pH.

7. The method of claim 1, wherein a carbon dioxide absorbing sensor is provided and used to sense carbon dioxide.

8. The method of claim 7, wherein the sensor is a solid polymer body of fixed length disposed at the distal end of an optical fiber and the sensor is used in vivo to sense carbon dioxide.

2. A method of sensing a parameter of blood comprising the steps of:

providing a stable optical sensor in solid form for sensing a parameter of blood;

determining an associated set of calibration data for the sensor by exposing the sensor to at least one calibration medium, measuring the optical response of the sensor to the medium and determining the associated calibration data based on the response, and then removing the sensor from the calibration medium;

recording the calibration data;

sterilizing the sensor prior to use;

storing the sensor for at least 24 hours; and

using the sensor and recorded calibration data to sense a parameter of blood.

5. The method of claim 2, wherein the sensor is provided with an oxygen-quenchable luminescent lanthanide complex and the sensor is used to sense oxygen.

6. The method of claim 5, wherein the complex is provided in a polymeric matrix at a distal end of an optical fiber and the sensor is used in vivo to sense oxygen.