Artificial tubular organ

• US 5,236,447 A
• Filed: 06/28/1991
• Issued: 08/17/1993
• Est. Priority Date: 06/29/1990
• Status: Expired due to Fees

• Current Assignee: Nissho Corporation (Nitto Denko Corporation)
• Original Assignee: Nissho Corporation (Nitto Denko Corporation)
• Inventors: Kubo, Yoshihiko, Arai, Takashi, Maeda, Tomiyo, Tsujikawa, Hajime, Nakajima, Susumu
• Primary Examiner(s): Isabella, David
• Assistant Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US07/723,251
• Time in Patent Office: 781 Days
• Field of Search: 623/9, 623/1, 623/12
• US Class Current: 623/1.13
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2/07 Stent-grafts
• CPC Class Codes: A61F 2/90 characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/075 the stent being loosely attached to the graft material, e.g. by stitching
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61L 2430/22 for reconstruction of hollow organs, e.g. bladder, esophagus, urether, uterus
• CPC Class Codes: A61L 27/14 Macromolecular materials
• CPC Class Codes: D03D 15/283 synthetic polymer-based, e.g. polyamide or polyester fibres cellulose-based artificial fibres D03D15/225
• CPC Class Codes: D03D 15/50 characterised by the properties of the yarns or threads
• CPC Class Codes: D03D 3/02 Tubular fabrics
• CPC Class Codes: D10B 2201/20 Cellulose-derived artificial fibres
• CPC Class Codes: D10B 2321/021 polyethylene
• CPC Class Codes: D10B 2321/022 polypropylene
• CPC Class Codes: D10B 2321/042 polymers of fluorinated hydrocarbons, e.g. polytetrafluoroethene [PTFE]
• CPC Class Codes: D10B 2321/06 polymers of unsaturated alcohols, e.g. polyvinyl alcohol, or of their acetals or ketals
• CPC Class Codes: D10B 2331/02 polyamides D10B2331/08 takes precedence
• CPC Class Codes: D10B 2331/04 polyesters, e.g. polyethylene terephthalate [PET]
• CPC Class Codes: D10B 2331/10 polyurethanes
• CPC Class Codes: D10B 2401/10 porous

Abstract

An artificial tubular organ composed of a tubular supporting frame made of a plastic material which is provided on at least one surface therefore with a medical prosthetic material. The supporting frame is composed of a plurality of ring portions arranged on an axis, and a plurality of pairs of connecting portions extending between adjacent two ring portions so as to connect them to each other, every other pair of the connecting portions being diametrically arranged on the ring portions, the remaining pairs of the connecting portions being arranged such that a plane containing their center lines is perpendicular to a plane containing the center lines of pairs of diametrically arranged connecting portions. The medical prosthetic material may be a woven fabric, a knitted fabric, a nonwoven fabric, or a combination thereof. Preferred fabric includes absorbable macromolecular yarns and nonabsorbable macromolecular yarns.

Claims

1. An artificial tubular organ comprising:

a tubular supporting frame made of a plastic material, and a biocompatible material layer having airtightness arranged on said supporting frame so as to cover at least a portion of a surface of said supporting frame, said supporting frame comprising a plurality of ring portions arranged on an axis, and a plurality of pairs of connecting portions extending between adjacent ring portions so as to connect said ring portions to each other, a first group of alternating pairs of said connecting portions being diametrically arranged on said ring portions, a second group of remaining alternating pairs of said connecting portions being arranged such that a plane containing center lines of a pair of said second group is perpendicular to a plane containing center lines of a pair of said first group of diametrically arranged connecting portions,

said biocompatible material layer comprising at least one fabric selected from the group consisting of woven fabrics, nonwoven fabrics, and knitted fabrics, wherein said fabric is partially absorbable in an organism such that the organism forms pores in the fabric, said pores having an average diameter of 300 to 1500 μ

m and a surface area which occupies at least 20% of a surface area of said fabric.

2. An artificial tubular organ according to claim 1, wherein said biocompatible material comprises a woven fabric comprising absorbable macromolecular yarns and nonabsorbable macromolecular yarns.

3. An artificial tubular organ according to claim 2, wherein the woven fabric comprises double yarns or twist yarns comprising at least one absorbable macromolecular yarn and at least one nonabsorbable macromolecular yarn.

4. An artificial tubular organ according to claim 2, wherein said nonabsorbable macromolecular yarns comprise fibers made of a material selected from the group consisting of polyesters, polyolefins, polyamide resins, fluoroplastics, chlorine resins, polyurethane resins, cellulose derivatives, and natural fibers.

5. An artificial tubular organ according to claim 2, wherein said nonabsorbable macromolecular yarns comprise polyolefin fibers.

6. An artificial tubular organ according to claim 2, wherein said biocompatible material is coated with a protein.

7. An artificial tubular organ according to claim 6, wherein said protein is selected from the group consisting of collagen, gelatin, fibrinogen, globulin and fibronectin.

8. An artificial tubular organ according to claim 2, wherein said absorbable macromolecular yarns are formed from a material selected from the group consisting of polylactide, polyglycolic acid, polyvinyl alcohol, polyacryl amide, polyvinyl pyrolidone, poly-γ

-methyl-glutamade, poly-caprolactone, polydioxanone, ethylene-carbo monoxide copolymers, cellulose derivatives, cellulose copolymers, and vinyl acetate-unsaturated carboxylic acid copolymers.

9. An artificial tubular organ according to claim 1, wherein the fabric is a nonwoven fabric comprising absorbable macromolecular fibers and nonabsorbable macromolecular fibers.

10. An artificial tubular organ according to claim 9, wherein said nonabsorbable macromolecular fibers comprise a material selected from the group consisting of polyesters, polyolefins, polyamide resins, fluoroplastics, chlorine resins, polyurethane resins, cellulose derivatives, and natural fibers.

11. An artificial tubular organ according to claim 10, wherein said nonabsorbable macromolecular fibers comprise polyolefin fibers.

12. An artificial tubular organ according to claim 9, wherein said absorbable macromolecular yarns are formed from a material selected from the group consisting of polylactide, polyglycolic acid, polyvinyl alcohol, polyacryl amide, polyvinyl pyrolidone, poly-γ

-methyl-glutamade, poly-caprolactone, polydioxanone, ethylene-carbo monoxide copolymers, cellulose derivatives, cellulose copolymers, and vinyl acetate-unsaturated carboxylic acid copolymers.

13. An artificial tubular organ according to claim 1, wherein said biocompatible material is coated with a protein.

14. An artificial tubular organ according to claim 13, wherein said protein is selected from the group consisting of collagen, gelatin, fibrinogen, globulin and fibronectin.

15. An artificial tubular organ according to claim 1 wherein the surface area occupied by said openings or pores is 40 to 70% of the surface area of said fabric.

16. An artificial tubular organ according to claim 1, wherein the surface area occupied by said pores is 40 to 70% of the surface area of said fabric.

17. An artificial tubular organ according to claim 1, wherein said artificial tubular organ has a Y-shaped form comprising three interconnected tubular supporting frames.

18. An artificial tubular organ comprising:

a tubular supporting frame made of a plastic material, and a biocompatible material layer arranged on said supporting frame so as to cover at least one surface of said supporting frame, said supporting frame comprising a plurality of ring portions arranged on an axis, and a plurality of pairs of connecting portions extending between adjacent ring portions so as to connect said ring portions to each other, a first group of alternating pairs of said connecting portions being diametrically arranged on said ring portions, a second group of remaining alternating pairs of said connecting portions being arranged such that a plane containing center lines of a pair of said second group is perpendicular to a plane containing center lines of a pair of said first group of diametrically arranged connecting portions,

said biocompatible material comprising at least one fabric selected from the group consisting of woven fabrics, nonwoven fabrics, and knitted fabrics, wherein said fabric is partially absorbable in the organism to form pores therein, said pores having an average diameter of at least 110 μ

m and a surface area which occupies at least 20% of the surface area of said fabric.

19. An artificial tubular organ according to claim 18, wherein said biocompatible material layer is coated with a protein that is selected from the group consisting of collagen, gelatin, fibrinogen, globulin and fibronectin.

20. An artificial tubular organ according to claim 18, wherein the surface area occupied by said pores is 40 to 70% of the surface area of said fabric.

21. An artificial tubular organ according to claim 18, wherein said artificial tubular organ has a Y-shaped form comprising three interconnected tubular supporting frames.

22. An artificial tubular organ according to claim 18, wherein said openings or pores have an average diameter of 300 to 1500 μ

m.