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Controlled release formulation

  • US 5,236,704 A
  • Filed: 01/27/1989
  • Issued: 08/17/1993
  • Est. Priority Date: 01/29/1988
  • Status: Expired due to Term
First Claim
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1. A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen as a carrier and a bioactive protein or peptide as an active ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.

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