Controlled release formulation
First Claim
1. A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen as a carrier and a bioactive protein or peptide as an active ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
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Accused Products
Abstract
A controlled release formulation which comprises a compound selected from the group consisting of organic acidic compounds and acid anhydrides or esters capable of generating one of the organic acidic compounds through hydrolysis together with an active ingredient and collagen as a carrier, said formulation being capable of exhibiting a predetermined release profile of the active ingredient. A process for producing said formulation is also provided.
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Citations
20 Claims
- 1. A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen as a carrier and a bioactive protein or peptide as an active ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
- 11. A method for controlling the release rate or release profile of an active ingredient from a sustained release composition comprising collagen and a hormone releasing factor ingredient, which method comprises incorporating into the composition at least one amino acid in an amount of 1 to 50% by weight in terms of the total weight of the composition, said amino acid having a pH of less than 7 when dissolved in water and being incorporated into said composition to control the release rate or release profile of said active ingredient from said composition.
Specification