Anti-cancer quinazoline derivatives
First Claim
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1. A compound of formula I:
- ##STR12## wherein R is1) hydrogen;
or2) an alkyl, alkenyl or alkynyl group of up to 6 carbon atoms;
n is O;
1 or 2;
Z represents --CH═
CH-- [or --O--] or --S--;
each X independently represents halogeno, C1 -C4 alkyl, C1 -C4 alkoxy, nitro or trifluoromethyl; and
Y represents a group of formula;
##STR13## or a pharmaceutically acceptable salt or ester thereof.
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Abstract
A compound of formula I: ##STR1## wherein R is hydrogen; oran alkyl, alkenyl or alkynyl group of up to 6 carbon atoms; nis O; 1 or 2; Z represents --CH═CH-- or --S--; each X independently represents halogeno, C1 -C4 alkyl, C1 -C4 alkoxy, nitro or trifluoromethyl; and Y represents a group of formula: ##STR2## or a pharmaceutically acceptable salt or ester thereof.
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14 Claims
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1. A compound of formula I:
- ##STR12## wherein R is
1) hydrogen;
or2) an alkyl, alkenyl or alkynyl group of up to 6 carbon atoms; n is O;
1 or 2;Z represents --CH═
CH-- [or --O--] or --S--;each X independently represents halogeno, C1 -C4 alkyl, C1 -C4 alkoxy, nitro or trifluoromethyl; and
Y represents a group of formula;
##STR13## or a pharmaceutically acceptable salt or ester thereof. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
- ##STR12## wherein R is
Specification