Dosage inhalator providing optimized compound inhalation trajectory

• US 5,239,993 A
• Filed: 08/26/1992
• Issued: 08/31/1993
• Est. Priority Date: 08/26/1992
• Status: Expired due to Fees

• Current Assignee: Glaxo, Inc. (Glaxo Holdings Plc)
• Original Assignee: Glaxo, Inc. (Glaxo Holdings Plc)
• Inventors: Evans, Rix E.
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): Raciti, Eric
• Application Number:
  US07/935,585
• Time in Patent Office: 370 Days
• Field of Search: 128/203.15, 128/203.23, 128/203.21, 128/203.12, 128/203.24, 128/200.21, 128/200.24
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 2202/064 Powder

Abstract

A breath actuated dry powder medicament inhalator has a primary air passageway therethrough defining a venturi in the medial portion thereof. A secondary air passageway is provided which includes a compound deaggregating swirl chamber and is fluidly connected to the venturi of the primary air passageway. A dry powder compound storage chamber and cooperatively associated metering plate act to introduce a predetermined amount of compound into the swirl chamber upon actuation of the metering plate. The primary air passageway is configured within the inhalator apparatus so as to create an optimized air flow trajectory through the mouth of the user to minimize dry powder compound impingement upon the outside radius of the throat.

Claims

1. A portable apparatus for the inhalation of a predetermined amount of a dry powder compound as an aerosol effluent, comprising:

an elongate housing defining a primary air passageway therethrough comprising a generally inclined air inlet portion having a first end and a second end, said first end of said inclined portion adapted to introduce air flow into said elongate housing at an angle between about 5°

-45°

below a horizontal baseline and an air exit portion at said second end of said inclined portion for insertion into the mouth, said primary air passageway further comprising a venturi position substantially in the medial portion thereof between said air inlet portion and said air exit portion;

a storage chamber formed in said housing for storing said compound to be inhaled;

a secondary air passageway in said housing comprising an air introduction portion having a first end and a second end, said first end of said introduction portion adjacent said air inlet portion of said primary air passageway and said second end of said introduction portion fluidly communicating with said venturi portion of said primary air passageway, said secondary air passageway further comprising an enlarged compound swirl chamber between said air introduction portion and said other end thereof; and

dose introduction means provided within said housing for transporting a predetermined portion of said compound from said storage chamber to said compound swirl chamber of said secondary air passageway;

whereby during inhalation the pressure differential between said venturi portion of said primary air passageway and said swirl chamber of said secondary air passageway serves to swirl the compound out of said swirl chamber and into said primary air passageway, and whereby the air flow pathway through said apparatus serves to introduce the compound along an optimized arcuate trajectory to the pharynx and larynx.

2. A portable apparatus according to claim 1 wherein said air inlet portion comprises means for introducing air flow into said elongate housing at an angle of about 15°

below a horizontal baseline.

3. A portable apparatus according to claim 1 wherein said elongate housing has an inlet end and an outlet end, said air inlet portion is positioned vertically lower at said inlet end of said elongate housing with respect to said horizontal baseline than said air exit portion at said outlet end of said elongate housing.

4. A portable apparatus according to claim 1 wherein said storage chamber is provided with a spring biased plate element to urge a compound therein toward said dose introduction means.

5. A portable apparatus according to claim 1 wherein said air introduction portion of said secondary air passageway is in fluid communication with and extends generally above and lengthwise relative to said air inlet portion of said primary air passageway in said elongate housing.

6. A portable apparatus according to claim 5 wherein said swirl chamber of said secondary air passageway is positioned generally above said venturi portion of said primary air passageway and defines a generally cylindrically-shaped chamber.

7. A portable apparatus according to claim 1 wherein said dose introduction means comprises a slidable metering plate with a compound-receiving aperture therein adapted to be slidably moved from a normally inoperative position with said aperture beneath said storage chamber to an operative position with said aperture introduced into said swirl chamber of said secondary air passageway.

8. A portable apparatus according to claim 7 wherein said dose introduction means further comprises an inwardly deflectable actuator button and said slidable metering plate is actuated by said inwardly deflectable actuator button mounted in said elongate housing of said inhalator apparatus.

9. A portable apparatus for the inhalation of a predetermined amount of a dry powder compound as an aerosol effluent, comprising:

an elongate housing defining a primary air passageway therethrough comprising a generally inclined air inlet portion having a first end and a second end, said first end of said inclined portion adapted to introduce air flow into said elongate housing at an angle of about 15°

below a horizontal baseline and an air exit portion at the said second end of said inclined portion for insertion into the mouth, said primary air passageway further comprising a venturi position substantially in the medial portion thereof between said air inlet portion and said air exit portion;

a storage chamber formed in said housing for storing said compound to be inhaled;

a secondary air passageway in said housing comprising an air introduction portion having a first end and a second end, said first end of said introduction portion fluidly communicating with and extending generally above and lengthwise relative to said air inlet portion of said primary air passageway, and said second end of said introduction portion fluidly communicating with said venturi portion of said primary air passageway, said secondary air passageway further comprising an enlarged compound swirl chamber between said air introduction portion and said other end thereof; and

dose introduction means provided within said housing for transporting a predetermined portion of said compound from said storage chamber to said compound swirl chamber of said secondary air passageway;

whereby during inhalation the pressure differential between said venturi portion of said primary air passageway and said swirl chamber of said secondary air passageway serves to swirl the compound out of said swirl chamber and into said primary air passageway, and whereby the air flow pathway through said apparatus serves to introduce the compound along an optimized arcuate trajectory to the pharynx and larynx.

10. A portable apparatus according to claim 9 wherein said elongate housing has an inlet end and an outlet end, said air inlet portion is positioned vertically lower at said inlet end of said elongate housing with respect to said horizontal baseline than said air exit portion at said outlet end of said elongate housing.

11. A portable apparatus according to claim 9 wherein said storage chamber is provided with a spring biased plate element to urge a compound therein toward said dose introduction means.

12. A portable apparatus according to claim 11 wherein said swirl chamber of said secondary air passageway is positioned generally above said venturi portion of said primary air passageway and defines a generally cylindrically-shaped chamber.

13. A portable apparatus according to claim 9 wherein said dose introduction means comprises a slidable metering plate with a compound-receiving aperture therein adapted to be slidably moved from a normally inoperative position with said aperture beneath said storage chamber to an operative position with said aperture introduced into said swirl chamber of said secondary air passageway.

14. A portable apparatus according to claim 13 wherein said dose introduction means further comprises an inwardly deflectable actuator button and said slidable metering plate is actuated by said inwardly deflectable actuator button mounted in said elongate housing of said inhalator apparatus.