Alpha-mannosidase and fucosidase inhibitors
First Claim
1. A composition comprising a compound of the formula ##STR7## wherein R is a (C1 -C6)alkyl optionally substituted with one or two hydroxy groups, a glycosyl group, a group of the formula --(CH2)n --Ar, wherein n is an integer of from 1 to 4 and Ar is a phenyl optionally substituted with one or two groups selected from (C1 -C4)alkyl, (C1 -C4)alkoxy, fluoro, chloro, bromo, iodo, amino, mono(C1 -C4)alkylamino or di(C1 -C4)alkylamino, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
1 Assignment
0 Petitions
Accused Products
Abstract
Substituted (1α,2β,3α or β,4α,5α or β)-2,3,4-trihydroxy-5-(hydroxymethyl)cyclopentylamines are inhibitors of alpha-mannosidase and alpha-fucosidase and are useful immunostimulants, antiviral and antimetastatic agents.
6 Citations
1 Claim
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1. A composition comprising a compound of the formula ##STR7## wherein R is a (C1 -C6)alkyl optionally substituted with one or two hydroxy groups, a glycosyl group, a group of the formula --(CH2)n --Ar, wherein n is an integer of from 1 to 4 and Ar is a phenyl optionally substituted with one or two groups selected from (C1 -C4)alkyl, (C1 -C4)alkoxy, fluoro, chloro, bromo, iodo, amino, mono(C1 -C4)alkylamino or di(C1 -C4)alkylamino, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
Specification
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- Resources
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Current AssigneeMerrell Pharmaceuticals Incorporated (Dow, Inc.)
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Original AssigneeMerrell Pharmaceuticals Incorporated (Dow, Inc.)
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InventorsPeet, Norton P., Farr, Robert A.
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Primary Examiner(s)Page, Thurman K.
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Assistant Examiner(s)AZPURU, CARLOS A
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Application NumberUS07/666,742Time in Patent Office902 DaysField of Search424/94.61, 424/405, 424/408, 424/409, 424/410, 424/422, 424/423, 424/451, 424/456, 424/463, 424/464, 424/85.1, 424/85.7, 548/453, 546/112US Class Current424/405CPC Class CodesC07C 215/44 bound to carbon atoms of th...C07C 2601/08 the ring being saturatedC07H 15/18 Acyclic radicals, substitut...C07H 15/203 Monocyclic carbocyclic ring...
