Noninvasive, non-occlusive method and apparatus which provides a continuous indication of arterial pressure and a beat-by-beat characterization of the arterial system

• US 5,241,964 A
• Filed: 10/31/1990
• Issued: 09/07/1993
• Est. Priority Date: 10/31/1990
• Status: Expired due to Fees

• Current Assignee: Medwave, Inc.
• Original Assignee: Medwave, Inc.
• Inventors: McQuilkin, Gary L.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): LACYK, JOHN P
• Application Number:
  US07/606,464
• Time in Patent Office: 1,042 Days
• Field of Search: 128/661.08, 128/661.09, 128/661.10, 128/672, 128/677, 128/680, 128/687, 128/689, 128/690, 128/691, 128/693, 128/694
• US Class Current: 600/485
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02156 Calibration means
• CPC Class Codes: A61B 8/04 Measuring blood pressure
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00

Abstract

A noninvasive arterial pressure monitor provides calibrated, continuous pressure waveform and beat-by-beat pressure values with no occlusion of an artery during an extended monitoring period. Noninvasive doppler sensors are secured over a major artery. Signals from the sensors are used to mathematically characterize the artery. The time-varying arterial resonant frequency is correlated to blood pressure throughout the cardiac cycle. Doppler sensors provide bi-directional flow velocity waveforms from which arterial resonant frequency may be calculated. A calibration cuff is used infrequently to calibrate the system to units of pressure.

Claims

1. An apparatus for measuring blood pressure comprising:

noninvasive sensor means for providing an output representative of blood flow in a blood carrying artery;

processing circuitry means coupled to the noninvasive sensor means for receiving the output representative of blood flow and providing a processed output;

resonant frequency identification circuitry means coupled to the processing circuitry means for receiving the processed output, calculating a time-varying resonant frequency of the artery and providing a resonant frequency output; and

output means coupled to the resonant frequency identification circuitry means for providing an output representative of blood pressure in the artery based upon the resonant frequency output.

2. The apparatus of claim 1 including calibration means coupled to the output means for calibrating a relationship between the time varying resonant frequency of the artery and the blood pressure in the artery.

3. The apparatus of claim 2 wherein the calibration means includes a noninvasive blood pressure measurement cuff.

5. The apparatus of claim 1 wherein the output means includes display means for displaying the output representative of blood pressure in the artery.

6. The apparatus of claim 1 wherein the output representative of blood pressure in the artery comprises a time varying blood pressure waveform.

7. The apparatus of claim 1 including means for receiving the output of blood flow and decomposing the output into representative component parameters representative of a waveform.

8. The apparatus of claim 1 including means for calibrating the resonant frequency output in units of Hertz.

9. The apparatus of claim 1 including means for receiving the resonant frequency output and calculating a waveform corresponding to the time-varying resonant frequency of the artery.

4. The apparatus of claim wherein the noninvasive sensor means comprises a plurality of doppler sensors.

10. An apparatus for measuring blood pressure comprising:

noninvasive blood velocity sensor means for sensing blood flow velocity in an artery;

means, coupled to the noninvasive blood velocity sensor means, for providing an output representative of a resonant frequency of the artery;

a resonant frequency to blood pressure conversion circuit means, coupled to the means for providing an output representative of a resonant frequency of the artery, for converting a resonant frequency of the artery to a blood pressure output; and

display means, coupled to the resonant frequency to blood pressure conversion circuit means, for displaying an output representative of blood pressure in the artery.

11. The apparatus of claim 10 including calibration means coupled to the resonant frequency to blood pressure conversion circuit means for calibrating the output representative of blood pressure in the artery.

12. The apparatus of claim 11 wherein the calibration means comprises a noninvasive blood pressure measurement cuff.

13. The apparatus of claim 10 wherein the noninvasive blood velocity sensor means comprises a doppler sensor.

14. The apparatus of claim 10 including means, connected to the noninvasive blood velocity sensor means, for decomposing a blood velocity waveform into its parameter components.

15. The apparatus of claim 10 including means for calibrating the resonant frequency output in units of Hertz.

16. The apparatus of claim 10 including means for receiving the resonant frequency output and calculating a waveform corresponding to the time-varying resonant frequency of the artery.

17. An apparatus for measuring blood pressure comprising:

means for measuring an arterial parameter which correlates to arterial resonant frequency;

means, coupled to the means for measuring an arterial parameter, for calculating blood pressure in the artery based upon arterial resonant frequency; and

output means, coupled to the means for calculating blood pressure, for providing an output representative of blood pressure.

18. The apparatus of claim 17 wherein the means for measuring an arterial parameter blood velocity comprises a doppler sensor.

19. The apparatus of claim 17 wherein the means for calculating blood pressure in the artery includes means for determining a resonant frequency waveform of the artery based upon the arterial parameter.

20. The apparatus of claim 17 including processing circuitry coupled to the means for measuring an arterial parameter through an artery.

21. The apparatus of claim 17 including calibration means coupled to the output means for calibrating a relationship between the arterial parameter and blood pressure in the artery.

22. The apparatus of claim 21 wherein the calibration means includes a noninvasive blood pressure measurement cuff.

23. The apparatus of claim 17 wherein the output means includes a display means for displaying the output representative of blood pressure.

24. The apparatus of claim 17 including means, coupled to the means for measuring an arterial parameter for decomposing waveform formed from the arterial parameter into its parameter components.

25. The apparatus of claim 17 including means, coupled to the means for calculating blood pressure, for calibrating arterial resonant frequency output in units of Hertz.

26. The apparatus of claim 17 including means for calculating a waveform corresponding to the time-varying resonant frequency of the artery based upon the blood arterial parameter.

27. A method of testing a blood vessel system, comprising:

deriving from a blood vessel a first signal from which a time-varying resonant frequency is derived;

processing the first signal to produce a second signal representative of the time-varying resonant frequency of the blood vessel system; and

providing a test output based upon the second signal representative of the time-varying resonant frequency of the blood vessel system.

28. The method of claim 27 wherein deriving a first signal, comprises deriving from a blood vessel a blood velocity signal representative of blood velocity.

29. The method of claim 27 wherein deriving a first signal, comprises deriving a blood velocity signal from a doppler sensor.

30. The method of claim 27 wherein the output includes a blood pressure output.

31. The method of claim 27 wherein deriving from a first signal comprises, deriving a blood velocity signal based upon doppler shift.

32. A method of measuring blood pressure comprising:

noninvasively deriving from an artery a signal from which time-varying arterial resonant frequency is derived;

processing the signal to produce a waveform representative of time-varying arterial resonant frequency; and

providing a blood pressure output based upon the waveform.

33. The method of claim 32 wherein noninvasively deriving a signal comprises deriving a blood velocity signal.

34. The method of claim 32 wherein processing the signal comprises decomposing the signal into waveform component parameters.

35. The method of claim 32 including calibrating the blood pressure output.

36. A method of blood pressure measurement comprising:

measuring blood flow velocity through an artery;

deriving from the blood flow velocity an arterial resonant frequency waveform; and

providing a blood pressure output based upon the waveform.

37. The method of claim 36 wherein measuring blood flow velocity, comprises measuring doppler shift.

38. The method of claim 36 including calibrating the blood pressure output.

39. A method of measuring blood pressure comprising:

sensing blood flow velocity in an artery with a first noninvasive sensor;

sensing blood flow velocity in the artery with a second noninvasive sensor positioned distally along the artery with respect to the first noninvasive sensor;

deriving from the blood flow velocities sensed by the first and second noninvasive sensors a time-varying arterial resonant frequency waveform; and

providing blood pressure output derived from the waveform.

40. The method of claim 39 wherein sensing blood flow velocities comprises sensing dopper shift.

41. The method of claim 39 including calibrating the blood pressure output.

42. An apparatus for testing a blood vessel system comprising:

a sensor means for coupling to a blood vessel system and providing a sensor output;

means for processing the sensor output to produce a resonant frequency signal representative of a time-varying resonant frequency of the blood vessel system; and

means for providing a test output representative of time-varying resonant frequency of the blood vessel system.

43. The apparatus of claim 42 wherein the sensor means comprises a blood velocity sensor.

44. The apparatus of claim 42 wherein the sensor means comprises a doppler sensor.

45. The apparatus of claim 42 including means for receiving the resonant frequency signal and producing an output representative of blood pressure.

46. The apparatus of claim 42 including means for calibrating an impedance plethysmography sensor to units of resonant frequency based upon the output.

47. The apparatus of claim 42 including means for calibrating an infrared perfusion sensor to units of resonant frequency based upon the output.

48. The apparatus of claim 42 including means for calibrating a partially inflated cuff to units of resonant frequency based upon the output.

49. An apparatus of claim 42 including means for calibrating a pressure transducer for applying against the wall of an artery to units of resonant frequency based upon the output.

50. An apparatus of claim 42 including means for calibrating a radio frequency sensor to units of resonant frequency based upon the output.

51. An apparatus of claim 42 including means for calibrating a magnetic field sensor to units of resonant frequency based upon the output.

52. An apparatus of claim 42 including means for calibrating an ultrasonic sensor to units of resonant frequency based upon the output.

53. An apparatus of claim 42 including means for calibrating changes in arterial geometry to units of resonant frequency based upon the output.

54. The apparatus of claim 42 including means for deriving a nonstationary time delay of components of the output representative of time-varying resonant frequency based upon the output.

55. The apparatus of claim 42 including means for deriving a time-varying propagation velocity of harmonic components of the output representative of a time-varying resonant frequency based upon the output.

56. The apparatus of claim 42 including means for deriving a signal representative of time variable phase shifts in the output representative of a time-varying resonant frequency based upon the output.

57. The apparatus of claim 42 including means for deriving an output representative of pulse-wave velocity based upon the output representative of time-varying resonant frequency based upon the output.

58. An apparatus for measuring blood pressure, comprising:

a noninvasive sensor means for deriving an arterial signal from which time-varying arterial resonant frequency is derived;

signal processing means for receiving the arterial signal and producing an resonant frequency output representative of arterial time-varying resonant frequency; and

means for providing a blood pressure output based upon the resonant frequency output.

59. The apparatus of claim 58 wherein the noninvasive sensor means comprises a blood velocity sensor.

60. The apparatus of claim 58 wherein the signal processing means includes means for decomposing the signal into waveform component parameters.

61. The apparatus of claim 58 including means for calibrating the blood pressure output.

62. An apparatus for measuring blood pressure, comprising:

means for measuring blood flow velocity through an artery;

means for deriving from the blood flow velocity an arterial resonant frequency waveform; and

output means for providing a blood pressure output based upon the waveform.

63. The apparatus of claim 62 wherein the means for measuring blood velocity comprises a doppler shift sensor.

64. The apparatus of claim 62 including means for calibrating the blood pressure output.

65. An apparatus for measuring blood pressure comprising:

a first noninvasive sensor means for sensing blood flow velocity in an artery;

a second noninvasive sensor means for sensing blood flow velocity in an artery;

means for deriving from the blood flow velocities sensed by the first and second noninvasive sensor means a time-varying arterial resonant frequency waveform; and

output means for providing a blood pressure output derived from the waveform.

66. The apparatus of claim 65 wherein the first and second noninvasive sensor means comprise doppler sensors.

67. The apparatus of claim 65 wherein the output means comprises means for providing a blood pressure output representative of blood pressure in the artery.

68. The apparatus of claim 67 including means for calibrating the blood pressure output.