Renin inhibitors
First Claim
1. A compound of the formula ##STR248## in which R1 represents straight-chain or branched alkyl having up to 4 carbon atoms, cyclohexyl or phenyl,L represents a group of the formula --CH2 --NR2 R3 in whichR2 and R3 are identical or different and in each case represent hydrogen, phenyl or represent straight-chain or branched alkyl having up to 4 carbon atoms, which is optionally substituted by phenyl pr pyridyl, or represent a group of the formula --COR9 in which R9 denotes straight-chain or branched alkyl having up to 4 carbon atoms, which may be substituted by phenyl or pyridyl, or denotes phenyl which, in turn, may be substituted by carboxyl, alkoxycarbonyl having up to 4 carbon atoms or by a group of the formula --CONR10 R11 in which R10 and R11 are identical or different and in each case denote cyclopentyl, hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms, which, in turn, may be substituted by phenyl or pyridyl, or one of the substituentsR2 and R3 represents an amino protecting group orR2 and R3 together represent phthalimido or morpholino or represents a group pf the formula ##STR249## in which R2'"'"' represents hydrogen andR3'"'"' represents hydrogen Boc, ethoxycarbonyl or pyridylacetyl, orR2'"'"' and R3'"'"' together represent a morpholino group, orL represents a group of the formula ##STR250##
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Accused Products
Abstract
Renin-inhibiting peptides of the formula ##STR1## in which X represents a group of the formula ##STR2## represents hydroxyl, alkoxy having up to 8 carbon atoms, benzyloxy or a group of the formula --NR4 R5,
A, B, D and E are identical or different and in each case
represent a direct bond,
represent a radical of the formula ##STR3## in which Z denotes oxygen, sulphur or the methylene group
represents a grouping of the formula ##STR4## m represents a number 0, 1 or 2, and L represents a group of the formula --CH2 --NR2R3
and physiologically acceptable salts thereof.
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Citations
1 Claim
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1. A compound of the formula ##STR248## in which R1 represents straight-chain or branched alkyl having up to 4 carbon atoms, cyclohexyl or phenyl,
L represents a group of the formula --CH2 --NR2 R3 in which R2 and R3 are identical or different and in each case represent hydrogen, phenyl or represent straight-chain or branched alkyl having up to 4 carbon atoms, which is optionally substituted by phenyl pr pyridyl, or represent a group of the formula --COR9 in which R9 denotes straight-chain or branched alkyl having up to 4 carbon atoms, which may be substituted by phenyl or pyridyl, or denotes phenyl which, in turn, may be substituted by carboxyl, alkoxycarbonyl having up to 4 carbon atoms or by a group of the formula --CONR10 R11 in which R10 and R11 are identical or different and in each case denote cyclopentyl, hydrogen or straight-chain or branched alkyl having up to 4 carbon atoms, which, in turn, may be substituted by phenyl or pyridyl, or one of the substituents R2 and R3 represents an amino protecting group or R2 and R3 together represent phthalimido or morpholino or represents a group pf the formula ##STR249## in which R2'"'"' represents hydrogen and R3'"'"' represents hydrogen Boc, ethoxycarbonyl or pyridylacetyl, or R2'"'"' and R3'"'"' together represent a morpholino group, or L represents a group of the formula ##STR250##
Specification