Diluent for perfluorocarbons employed for retinal unfolding (unfolding PFCL) and method of treatment

• US 5,244,924 A
• Filed: 01/24/1992
• Issued: 09/14/1993
• Est. Priority Date: 01/24/1991
• Status: Expired due to Fees

• Current Assignee: Chiron Adatomed Pharmazeutische und Medizintechnische GmbH
• Original Assignee: Adatomed Pharmazeutische und Medizintechnische GmbH
• Inventors: Meinert, Hasso
• Primary Examiner(s): Raymond, Richard L.
• Assistant Examiner(s): RAND, SCOTT
• Application Number:
  US07/823,652
• Time in Patent Office: 599 Days
• Field of Search: 570/134, 514/759, 514/912, 514/672, 514/722, 514/757, 604/28, 604/49, 604/56, 564/510, 568/683
• US Class Current: 514/759
• CPC Class Codes: A61K 31/02 Halogenated hydrocarbons
• CPC Class Codes: A61K 31/08 acyclic, e.g. paraformaldehyde
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence

Abstract

A diluent for perfluorocarbons used for retinal unfolding (unfolding PFCL), consisting of a perfluorocarbon (diluent PFCL), which has a low viscosity and is volatile at room temperature, with a boiling point between body temperature (about 38° C.) and 100° C., for removing residual quantities of unfolding PFCL from the eye after performance of a retinal unfolding treatment. A method of treatment consisting of introducing into an eye the above diluent for the above purpose.

Claims

1. A method of treating an eye for retinal detachment, comprising the steps of:

(a) removing a vitreous body from the eye;

(b) introducing into the eye at least one viscous, nonvolatile perfluorocarbon liquid (unfolding PFCL) which causes the retina to again press back against choroid tissue of the eye;

(c) removing the unfolding PFCL from the eye;

(d) introducing into the eye at least one perfluorocarbon liquid (diluent PFCL), different from the unfolding PFCL introduced in step (b), having a low viscosity and volatile at room temperature, with a boiling point between 38°

C. and 100°

C.;

(e) dissolving during a residence time, residual quantities of the unfolding PFCL into the diluent PFCL; and

(f) aspirating the mixture of the diluent PFCL and the therein previously dissolved unfolding PFCL.

2. The method of claim 1, further comprising the step of:

(g) waiting a predetermined time after the aspirating step in order to permit evaporation of residual quantities of the diluent, together with the dissolved unfolding PFCLs.

3. The method of claim 2, further comprising the step of:

(h) rinsing the eye with an inert gas.

4. The method of claim 1, wherein 1 to 3 cm³ of diluent PFCL are introduced into the eye.