Cellulose chromatography support
First Claim
1. A chromatographic support comprising substantially spherical, non-cross-linked, high density cellulose particles wherein said particles have a bulk dry apparent density of about 0.65 to 0.85 g/ml, wherein said particles have an average diameter in the range of from about 25 microns to about 200 microns, and wherein said particles are essentially nonswelling in aqueous or organic solutions.
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Abstract
This invention relates to an improved cellulose chromatography support and, in particular, to substantially spherical, high density cellulose particles. This invention also relates to a method of making these spherical, high density cellulose particles and, in particular, to a method for forming spherical cellulose from a high molecular weight viscose in a stable emulsion of a liquid carrier and emulsifying agents.
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Citations
18 Claims
- 1. A chromatographic support comprising substantially spherical, non-cross-linked, high density cellulose particles wherein said particles have a bulk dry apparent density of about 0.65 to 0.85 g/ml, wherein said particles have an average diameter in the range of from about 25 microns to about 200 microns, and wherein said particles are essentially nonswelling in aqueous or organic solutions.
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9. A method of making substantially spherical, high density cellulose particles comprising the steps of:
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forming a stable emulsion of viscose in the presence of at least one emulsifying agent and a liquid carrier, wherein the temperature of said viscose during the formation of said emulsion does not thermally decompose said viscose; regenerating cellulose from said viscose in the absence of acid over a period of time with continuous agitation under stationary hydrodynamic conditions to yield a dispersion of uniformly sized, deformable particles; contacting said dispersion of deformable particles with a solvent suitable to cause a partial extraction of said liquid carrier from said emulsion, wherein said deformable particles begin to partially harden; and hardening said deformable particles whereby high density particles having an average diameter in the range of from about 25 microns to about 200 microns are produced. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17)
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18. Spherical, high density cellulose particles made by a method comprising the steps of:
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forming a stable emulsion of viscose in the presence of at least one emulsifying agent and a liquid carrier, wherein the temperature of said viscose during the formation of said emulsion does not thermally decompose said viscose; regenerating cellulose from said viscose in the absence of acid over a period of time with continuous agitation under stationary hydrodynamic conditions to yield a dispersion of uniformly sized, deformable particles; contacting said dispersion of deformable particles with a solvent suitable to cause a partial extraction of said liquid carrier from said emulsion, wherein said deformable particles begin to partially harden; and hardening said deformable particles to produce high density particles having an average diameter in the range of from about 25 microns to about 200 microns.
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Specification