Infrared cholesterol sensor

• US 5,246,004 A
• Filed: 08/14/1992
• Issued: 09/21/1993
• Est. Priority Date: 02/02/1990
• Status: Expired due to Fees

• Current Assignee: Diabetes Control & Care Technology, Inc.
• Original Assignee: AngioMedics II Incorporated.
• Inventors: Wang, Qian, Clarke, Richard H.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): Nasser, Robert L.
• Application Number:
  US07/929,941
• Time in Patent Office: 403 Days
• Field of Search: 128/633, 128/666, 356/41
• US Class Current: 600/322
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

Systems and methods for non-invasive blood analysis are disclosed in which blood is illuminated at a plurality of discrete wavelengths selected from the near infrared spectrum. Measurements of the intensity of reflected or transmitted light at such wavelengths are taken, and an analysis of reflectance or transmittance ratios for various wavelengths is performed. Changes in the ratios can be correlated with specific material properties, such as the concentration of cholesterol in a subject'"'"'s circulatory system.

Claims

1. A blood-cholesterol detection apparatus comprising:

illumination means for non-invasively illuminating an in vivo blood sample in a patient at a plurality of infrared wavelengths for generating a background reference signal and a cholesterol data signal;

detector means for non-invasively detecting light effected by said sample at least one data wavelength and at one reference wavelength for each data wavelength of said plurality of wavelengths and for converting said detected light into electrical signals, said electrical signals being indicative of the intensity of said effected light at said data and reference wavelengths, said data and reference wavelengths being separated by no more than about 100 nm; and

analyzing means for receiving and comparing said electrical signals to derive a ratio for at least said data and reference wavelengths, such that said ratio can be compared with predetermined values associated with known blood-cholesterol concentrations so as to detect the cholesterol level in said sample.

2. The apparatus of claim 1 wherein said illumination means further comprises at least two light sources, each producing light at a distinct wavelength within a window at about 1620-1820 nm.

3. The apparatus of claim 2 wherein a first one of said sources is operable at about 1720 nm.

4. The apparatus of claim 1 wherein said illumination means further comprises at least two light sources, each producing light at a distinct wavelength within a window at about 2200-2400 nm.

5. The apparatus of claim 4 wherein a first one of said sources is operable at about 2300 nm.

6. The apparatus of claim 1 wherein said illumination means further comprises at least two light sources, each of said light sources producing light at a distinct data wavelength, one of which being at about 1720 nm and the other at about 2300 nm, for making separate measurements of cholesterol absorption data.

7. The apparatus of claim 1 wherein said illumination means further comprises at least two light sources, each producing light at a distinct wavelength with a first one of said sources operable at about 100 nm away from a second one of said sources.

8. The apparatus of claim 1 wherein said analyzing means further comprises means for quantifying the concentration of cholesterol in said sample.

9. The apparatus of claim 1 wherein said detector means detects light reflected by said sample at said plurality of wavelengths.

10. The apparatus of claim 1 wherein said detector means detects light transmitted by said sample at said plurality of wavelengths.

11. A method for detecting blood-cholesterol levels in vivo, comprising the steps of:

illuminating a source of blood non-invasively through the tissue of a subject with light at a plurality of infrared wavelengths for generating a background reference signal and a cholesterol data signal;

detecting said infrared light at at least one data wavelength and at one reference wavelength for each data wavelength of said plurality of wavelengths as effected by said blood and converting said detected light into electrical signals indicative of the intensity of said effected light at said wavelengths, said data and reference wavelengths being separated by no more than about 100 nanometers;

analyzing said electrical signals to derive a ratio for said data and reference wavelengths; and

comparing said ratio to a predetermined value to detect the presence of cholesterol in said blood.

12. The method of claim 11 wherein the step of comparing includes detecting the concentration of cholesterol in said blood.

13. The method of claim 12 wherein said step of illuminating further comprises illuminating said blood source with at least two light sources, each producing light at a distinct cholesterol data wavelength, one of said at least two light sources being at about 1720 nm and the other at about 2300 nm.

14. The method of claim 11 wherein said step of illuminating further comprises the step of illuminating the blood source at a wavelength at about 1720 nm.

15. The method of claim 11 wherein said step of illuminating further comprises the step of illuminating the blood at a wavelength at about 2300 nm.

16. The method of claim 11 wherein said step of analyzing further comprises the step of quantifying the concentration of cholesterol in said sample.

17. The method of claim 11 wherein said step of detecting further comprises the step of detecting light reflected by said sample at said plurality of wavelengths.

18. The method of claim 11 wherein said step of detecting further comprises the step of detecting light transmitted by said sample at said plurality of wavelengths.

19. A blood-cholesterol detection apparatus comprising:

illumination means for non-invasively illuminating an in vivo blood sample in a patient at a plurality of infrared wavelengths, said illumination means further comprising at least two light sources, with a first one of said sources being operable at a first one of said wavelengths and a second one of said sources being operable at a second one of said wavelengths about 100 nm away from said first wavelength, for generating a background reference signal and a cholesterol data signal within a narrow measurement window;

detector means for non-invasively detecting light effected by said sample at said reference and data wavelengths and for converting said detected light into electrical reference and data signals, said electrical signals being indicative of the intensity of said effected light at said first and second wavelengths; and

analyzing means for receiving and comparing said electrical signals to derive a ratio for said first and second wavelengths, such that said ratio can be compared with predetermined values associated with known blood-cholesterol concentrations so as to detect the cholesterol level in said blood sample.

20. The apparatus of claim 19 wherein said sources each produce light at a distinct wavelength within said window at about 1620-1820 nm.

21. The apparatus of claim 20 wherein one of said sources is operable at about 1720 nm.

22. The apparatus of claim 19 wherein said sources each produce light at a distinct wavelength within said window at about 2200-2400 nm.

23. The apparatus of claim 22 wherein one of said sources is operable at about 2300 nm.

24. The apparatus of claim 19 wherein one of said light sources operates at about 1720 nm, further comprising at least two additional light sources one of which operating at about 2300 nm, for making separate measurements of cholesterol absorption data at 1720 and 2300 nm.

25. A method for detecting blood-cholesterol levels in vivo, comprising the steps of:

illuminating a source of blood non-invasively through the tissue of a subject with at least two light sources, each producing light at a distinct infrared wavelength within a window at about 100 nm wide, for generating a background reference signal and a cholesterol data signal;

detecting said infrared light as effected by said blood and converting said detected light into electrical signals indicative of the intensity of said effected light at said wavelengths;

analyzing said electrical signals to derive a ratio for said wavelengths; and

comparing said ratio to a predetermined value to detect the presence and concentration of cholesterol in said blood.

26. The method of claim 25 wherein said step of illuminating further comprises the step of illuminating the blood at a wavelength at about 1720 nm.

27. The method of claim 25 wherein said step of illuminating further comprises the step of illuminating the blood at a wavelength at about 2300 nm.