Method and apparatus for determining the motility of a region in the human body
First Claim
1. An apparatus for simultaneously measuring thickness of a wall of the digestive tract and the local pressure within the digestive tract of a living body, comprising:
- an ultrasonic transducer within a probe that is adapted to be attached in a fixed position to said wall within said living body;
a transmitter means for causing said transducer to emit a plurality of ultrasonic pulses into said wall at a selected rate;
a receiver means for receiving electronic signals from said transducer corresponding to ultrasonic energy reflected from said wall, the round trip time for the ultrasonic energy reflected from said wall being indicative of the thickness of the wall for the reflected ultrasonic energy;
a pressure sensor means adjacent said transducer for measuring the gas pressure in said digestive tract simultaneously with said transducer transmitting ultrasonic energy into walls of said digestive tract;
a flexible coupling means connecting said transmitter means to said transducer for permitting said transducer to move freely with respect to said transmitter means to permit movement of said wall to which said transducer is adapted to be attached; and
a display means for displaying said received electronic signals.
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Accused Products
Abstract
Devices are described which can be used to study the physiological function of the intestinal wall. These devices include an ultrasonic transducer that can be attached to a region of the intestinal wall. The transducer interrogates the wall and echoes are obtained from the different wall layers. The echoes are processed to produce an M-mode display of the wall. This allows monitoring how the wall changes with time. For example, as the wall contracts the muscle layer thickens and this action may be observed with the device. Other sensors and electrodes can be combined with this probe to correlate various physiological action. Finally, several such probes can be combined into a common introducible probe but which will monitor several regions along the intestinal wall. The major advantage of the disclosed device is that it provides a measurement of intestinal motility previously unattainable and it is introducible by endoscopy. This makes it a suitable tool for studying patient disease.
194 Citations
21 Claims
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1. An apparatus for simultaneously measuring thickness of a wall of the digestive tract and the local pressure within the digestive tract of a living body, comprising:
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an ultrasonic transducer within a probe that is adapted to be attached in a fixed position to said wall within said living body; a transmitter means for causing said transducer to emit a plurality of ultrasonic pulses into said wall at a selected rate; a receiver means for receiving electronic signals from said transducer corresponding to ultrasonic energy reflected from said wall, the round trip time for the ultrasonic energy reflected from said wall being indicative of the thickness of the wall for the reflected ultrasonic energy; a pressure sensor means adjacent said transducer for measuring the gas pressure in said digestive tract simultaneously with said transducer transmitting ultrasonic energy into walls of said digestive tract; a flexible coupling means connecting said transmitter means to said transducer for permitting said transducer to move freely with respect to said transmitter means to permit movement of said wall to which said transducer is adapted to be attached; and a display means for displaying said received electronic signals. - View Dependent Claims (2, 3, 4)
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5. An apparatus for measuring thickness of a wall of the digestive tract of a living body, comprising:
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an ultrasonic transducer within a probe that is adapted to be attached in a fixed position to said wall of the digestive tract; a transmitter means for causing said transducer to emit a plurality of ultrasonic pulses into said wall at a selected rate; a receiver means for receiving electronic signals from said transducer corresponding to ultrasonic energy reflected from said wall, the round trip time for the ultrasonic energy reflected from said wall being indicative of the thickness of the wall for the reflected ultrasonic energy; a muscle tension sensor means adjacent to said transducer for measuring the tension in said muscle adjacent to said transducer; a flexible coupling means connecting said transmitter means to said transducer for permitting said transducer to move freely with respect to said transmitter means to permit movement of said wall to which said transducer is adapted to be attached; and a display means for displaying said received electronic signals.
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6. An apparatus for measuring movement of a portion of a living body comprising:
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an ultrasonic transducer within a probe that is adapted to be attached in a fixed position to said living body; a transmitter means for causing said transducer to emit a plurality of ultrasonic pulses into said living body at a selected along a given scan line direction rate; a receiver means for receiving electronic signals from said transducer corresponding to ultrasonic energy reflected from within said body; a data storage means for storing data corresponding to said electronic signals, said data being stored in scan lines, one scan line storing data for each pulse transmitted, the stored data being representative of movement of a portion of the living body; a variable data reading means for reading only said scan lines which are temporally separate from each other by a predetermined variable number of scan lines; a display means for displaying said scan lines which have been read by said variable data reading means. - View Dependent Claims (7, 8)
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9. The method of studying movement of a wall within a living body, comprising:
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attaching a plurality of ultrasonic transducer probes to said wall within said living body, said transducer probes being spaced from each other along said wall of said living body; coupling the plurality of probes to each other with a flexible coupling, each of the probes including an ultrasonic transducer; transmitting ultrasonic energy into said wall at a selected frequency for each of said probes within the plurality of probes; receiving ultrasonic energy reflected from individual regions within said wall, by each probe of said plurality, said frequency being selected to image individual regions within said wall; repeating said transmitting and receiving steps a plurality of times over a selected interval of time; and producing a plot of individual regions within said wall over time based on the ultrasonic energy reflected from said individual regions over time, at which each probe within said plurality of probes is positioned. - View Dependent Claims (10, 11, 12, 13)
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14. An apparatus for determining the motility of a region of a living body, comprising:
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a plurality of probes, each having an ultrasonic transducer, said probes being adapted to be attached to said region; a transmitter means for providing an electrical signal to said transducers, causing them to emit an ultrasonic pulse; a receiver means for receiving electrical signals from said transducers representative of the ultrasonic energy reflected from said region; a multiplexer means for selectively coupling said transmitter means to one of said plurality of said transducers; a plotting means for producing a line in a plot corresponding to the received signals; a line selection means coupled to said plotting means for selectively providing to said plotting means some of said received signals, and blocking some of said signals from said plotting means, such that said plot includes lines for some of said received signals and does not include lines for other of said received signals; and a clock means coupled to said transmitter means for causing said transmitter means to emit said electrical signals at selected intervals. - View Dependent Claims (15, 16, 17, 18)
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19. A method of simultaneously measuring movement of walls of the digestive tract within an esophagus and within a large intestine of a living body comprising:
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attaching an ultrasonic transducer probe to a wall of said digestive tract within said esophagus; attaching an ultrasonic transducer probe to a wall of said digestive tract within said intestine; simultaneously transmitting ultrasonic energy into said esophagus wall and said intestine wall via respective transducers; receiving the transmitted ultrasonic energy that is reflected back from the esophagus wall and the intestine wall respective via respective transducers; repeating said transmitting and receiving steps a plurality of times over a selected interval of time; and producing a plot of the change in thickness of regions within said respective walls over time based on the ultrasonic energy reflected from said regions over time.
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20. The method of studying movement of a wall within a lumen of a living body, comprising:
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attaching an ultrasonic transducer probe to said wall within said living body; transmitting ultrasonic energy into said wall; receiving ultrasonic energy reflected from regions within said wall; repeating said transmitting and receiving steps a plurality of times over a selected interval of time; producing a plot of regions within said wall over time based on the ultrasonic energy reflected from said regions over time; and measuring the local pressure within said lumen simultaneously with performing said transmitting and receiving steps.
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21. The method of studying movement of a wall within a living body, comprising:
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attaching an ultrasonic transducer probe to said wall within said living body using a rigid rod coupled to said probe, said transducer probe being connected to a control circuit with a coupling member; removing said rigid rod from being coupled to said transducer probe after said transducer probe is attached to said wall to render said coupling flexible between said transducer probe and said control circuit; transmitting ultrasonic energy into said wall; receiving ultrasonic energy reflected from regions within said wall; repeating said transmitting and receiving steps a plurality of times over a selected interval of time; and producing a plot of regions within said wall over time based on the ultrasonic energy reflected from said regions over time.
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Specification