Extruded tubing and catheters having helical liquid crystal fibrils

• US 5,248,305 A
• Filed: 08/24/1992
• Issued: 09/28/1993
• Est. Priority Date: 08/04/1989
• Status: Expired due to Term

• Current Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Original Assignee: Cordis Corporation (Cardinal Health, Inc.)
• Inventors: Zdrahala, Richard J.
• Primary Examiner(s): Yasko, John D.
• Assistant Examiner(s): Gutowski, Anthony
• Application Number:
  US07/933,667
• Time in Patent Office: 400 Days
• Field of Search: 604/264, 604/280, 604/282, 128/656, 128/658, 138/125, 138/132, 138/137, 138/140, 138/153, 428/1, 428/36.9, 428/36.91
• US Class Current: 604/527
• CPC Class Codes: A61M 25/0009 Making of catheters or other medical or surgical tubes
• CPC Class Codes: A61M 25/005 with embedded materials for reinforcement, e.g. wires, coils, braids
• CPC Class Codes: A61M 25/0053 having a variable stiffness along the longitudinal axis, e.g. by varying the pitch of the coil or braid
• CPC Class Codes: B29C 48/0016 using a plurality of extrusion dies
• CPC Class Codes: B29C 48/09 Articles with cross-sections having partially or fully enclosed cavities, e.g. pipes or channels
• CPC Class Codes: B29C 48/10 flexible, e.g. blown foils
• CPC Class Codes: B29C 48/21 the layers being joined at their surfaces
• CPC Class Codes: B29C 48/33 with parts rotatable relative to each other
• CPC Class Codes: B29C 48/335 Multiple annular extrusion nozzles in coaxial arrangement, e.g. for making multi-layered tubular articles
• CPC Class Codes: B29C 48/34 Cross-head annular extrusion nozzles, i.e. for simultaneously receiving moulding material and the preform to be coated
• CPC Class Codes: B29K 2105/0079 Liquid crystals
• CPC Class Codes: B29L 2031/7542 Catheters

Abstract

Extruded catheters and other flexible plastic tubing may be manufactured with improved rotational and/or longitudinal stiffness, compared with catheters made of more conventional plastics. A tubing of liquid crystal polymer plastic-containing material may be extruded through a tube extrusion die while rotating the inner and outer die walls to provide circumferential shear to the extruded tube. Thus the liquid crystal polymer is oriented in a helical manner to provide improved properties, including greater rotational stiffness.

Claims

1. In an extruded plastic catheter which defines a tubular catheter body, the improvement comprising, in combination:

said catheter body being substantially defined by an extruded, tubular first layer, said first layer comprising, intermixed together, from 1 to 40 weight percent of a liquid crystal polymer and 60 to 99 weight percent of a different, softer structural plastic matrix which is not a liquid crystal polymer, said liquid crystal polymer defining a separate phase from said structural plastic matrix, said first layer exhibiting at least a degree of circumferential orientation to provide an increased amount of rotational stiffness to at least a section of said catheter body, said separate phase of the liquid crystal polymer defining generally helically extending fibrils dispersed throughout essentially the entire volume of said first layer, said fibrils being formed from liquid crystal polymer plastic droplets dispersed in said structural plastic matrix.

2. The catheter of claim 1 in which said catheter body carries a second layer of a polymer formulation having tissue compatible characteristics.

3. The catheter of claim 1 in which various sections of said catheter body exhibit differing degrees of circumferential orientation of said fibrils and rotational stiffness.

4. The catheter of claim 1 in which said fibrils generally exhibit an aspect ratio of 10 to 300.

5. The catheter of claim 1 in which said liquid crystal polymer exhibits a greater propensity than poly(ethylene terephthalate) to orient during melt flow and to retain such orientation.

6. The catheter of claim 1 in which said catheter body is free of any added fibrous support means.

7. The catheter of claim 1 in which said liquid crystal polymer comprises a prepolymer of poly(ethylene terephthalate), reacted with p-hydroxybenzoic acid.

8. The catheter of claim 1, in which said liquid crystal polymer plastic-containing material comprises from 5 to 35 weight percent of said liquid crystal polymer.

9. The catheter of claim 1 in which said liquid crystal polymer is a terpolymer of hydroxybenzoic acid, ethylene glycol, and terephthalic acid.

10. The catheter of claim 1 in which substantially all of said fibrils extend longitudinally along said tube for no more than a minor portion of the length thereof.

11. An extruded plastic tubing which defines a tubular body, said tubular body defining a tubular layer which comprises a mixture of a minor portion of a liquid crystal polymer and a major portion of a structural plastic matrix which is not a liquid crystal polymer, said liquid crystal polymer defining a separate phase from said structural plastic matrix with the structural plastic matrix and the liquid crystal polymer phases comprising a blended mixture which is dispersed together, said tubular layer exhibiting at least a degree of circumferential orientation to provide an increased amount of rotational stiffness to at least a section of said tube, the separate phase of said liquid crystal polymer defining generally helically extending fibrils dispersed throughout essentially the entire volume of said tubular layer.

12. The plastic tube of claim 11 in which said structural plastic matrix is made of a softer material than said liquid crystal polymer.

13. The plastic tube of claim 11 which comprises from 1 to 40 weight percent of said liquid crystal polymer and 60 to 99 weight percent of said structural plastic matrix.

14. The plastic tube of claim 11 in which said fibrils generally exhibit an aspect ratio of 10 to 300.

15. The plastic tube of claim 11 in which said liquid crystal polymer exhibits a greater propensity than poly(ethylene terephthalate) to orient during melt flow and to retain such orientation.

16. The plastic tube of claim 11 in which said catheter body is free of any added fibrous support means.

17. The plastic tube of claim 11 in which said liquid crystal polymer comprises a prepolymer of poly(ethylene terephthalate), reacted with p-hydroxybenzoic acid.

18. The plastic tube of claim 11 in which said liquid crystal polymer plastic-containing material comprises from 5 to 35 weight percent of said liquid crystal polymer.

19. The plastic tube of claim 11 in which substantially all of said fibrils extend longitudinally along said tube for no more than a minor portion of the length thereof.