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Pyrazolopyrimidinone antianginal agents

  • US 5,250,534 A
  • Filed: 05/14/1992
  • Issued: 10/05/1993
  • Est. Priority Date: 06/20/1990
  • Status: Expired due to Term
First Claim
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1. A compound of the formula:

  • ##STR22## wherein R1 is H, C1 -C3 alkyl, C3 -C5 cycloalkyl or C1 -C3 perfluoroalkyl;

    R2 is H, C1 -C6 alkyl optionally substituted by OH, C1 -C3 alkoxy or C3 -C6 cycloalkyl, or C1 -C3 perfluoroalkyl;

    R3 is C1 -C6 alkyl, C3 -C6 alkenyl, C3 -C6 alkynyl, C3 -C7 cycloalkyl, C1 -C6 perfluoroalkyl or (C3 -C6 cycloalkyl)C1 -C6 alkyl;

    R4 taken together with the nitrogen atom to which it is attached completes a 4-N-(R6)-piperazinyl group;

    R5 is H, C1 -C4 alkyl, C1 -C3 alkoxy, NR7 R8, or CONR7 R8 ;

    R6 is H, C1 -C6 alkyl, (C1 -C3 alkoxy) C2 -C6 alkyl hydroxy C2 -C6 alkyl, (R7 R8 N)C2 -C6 alkyl, (R7 R8 NCO)C1 -C6 alkyl, CONR7 R8, CSNR7 R8 or C(NH)NR7 R8 ;

    R7 and R8 are each independently H, C1 -C4 alkyl, (C1 -C3 alkoxy)C2 -C4 alkyl or hydroxy C2 -C4 alkyl; and

    pharmaceutically acceptable salts thereof.

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