Tissue oxygen measuring system

• US 5,251,632 A
• Filed: 07/09/1991
• Issued: 10/12/1993
• Est. Priority Date: 03/07/1991
• Status: Expired due to Fees

• Current Assignee: Hamamatsu Photonics KK
• Original Assignee: Hamamatsu Photonics KK
• Inventors: Delpy, David T.
• Primary Examiner(s): Cohen, Lee S.
• Assistant Examiner(s): NASSER, ROBERT L
• Application Number:
  US07/727,168
• Time in Patent Office: 826 Days
• Field of Search: 128/633, 128/666, 128/204.23, 128/204.22, 128/205.23, 128/691, 356/41
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

A tissue oxygen measuring system enabling the automatic and continuous measurement of diagnosing items including cerebral blood flow, cerebral blood volume, and response of cerebral blood volume in arterial carbon dioxide tension uses an oxygen measuring system based on near infrared spectroscopy, a pulse oximeter, and an arterial carbon dioxide tension measuring unit. A gas blending unit is employed before a ventilator or face mask to control the ventilator so that a rate of a quantity of oxygen and/or a quantity of carbon dioxide to be blended in the air is changed at predetermined intervals. Trigger signals are produced in synchronism with the changes of the gaseous contents of the air, and parameters for computing information regarding the diagnosing items are measured in response to the trigger signals. With the repetitive measurements of the parameters, a signal-to-noise ratio can be improved by averaging the data and erroneous data can easily be identified.

Claims

1. A tissue oxygen measuring system comprising:

a ventilator unit for supplying air to a living subject for the living subject to breath;

a control means connected to said ventilator unit for controlling said ventilator unit to cyclically change gaseous content of the air at a predetermined interval;

means for producing trigger signals in timed relation to the cyclic changes of the gaseous content of the air;

measuring means for measuring oxygen in a tissue of the living subject and supplying data regarding measured results; and

a data processing means responsive to the trigger signals for receiving the data from said measuring means and based on said trigger signals cyclically computing information regarding blood flowing in the tissue.

2. A tissue oxygen measuring system according to claim 1, wherein said measuring means comprises a first measuring means for measuring changes in oxyhemoglobin and dioxyhemoglobin in blood flowing in the tissue by near infrared ray spectroscopy, and a second measuring means for measuring a saturation of oxygen in an artery.

3. A tissue oxygen measuring system according to claim 2, wherein said data processing means includes means for cyclically computing at least one of a cerebral blood flow and a cerebral blood volume based on the data received from said first and second measuring units.

4. A tissue oxygen measuring system according to claim 3, further comprising third measuring means for measuring an arterial carbon dioxide tension of the living subject and providing data regarding measured results.

5. A tissue oxygen measuring system according to claim 4 wherein said data processing means cyclically computes a ratio of change in cerebral blood volume to change in arterial carbon dioxide tension.

6. A tissue oxygen measuring system according to claim 5, wherein said data processing means cyclically computes the cerebral blood flow, the cerebral blood volume, and the ratio of change in cerebral blood volume to change in arterial carbon dioxide tension.

7. A tissue oxygen measuring system according to claim 3, wherein said control means includes means for controlling said ventilator unit to cyclically change a rate of one of oxygen quantity and carbon dioxide quantity to be contained in the air.

8. A tissue oxygen measuring system according to claim 3, further comprising display means for displaying results computed by said data processing means.

9. A tissue oxygen measuring system according to claim 3, further comprising averaging means for averaging a plurality of data regarding each of the cerebral blood flow, the cerebral blood volume, and the ratio of change in cerebral blood volume to change in arterial carbon dioxide tension obtained through the cyclic changes of the gaseous contents of the air.

10. A tissue oxygen measuring system according to claim 2, further comprising third measuring means for measuring an arterial carbon dioxide tension of the living subject and providing data regarding measured results.

11. A tissue oxygen measuring system according to claim 10, wherein said data processing means cyclically computes a ratio of change in cerebral blood volume to change in arterial carbon dioxide tension.

12. A tissue oxygen measuring system according to claim 11 wherein said data processing means cyclically computes the cerebral blood flow, the cerebral blood volume, and the ratio of change in cerebral blood volume to change in arterial carbon dioxide tension.

13. A tissue oxygen measuring system according to claim 10 wherein said control means controls said ventilator unit to cyclically change a rate of carbon dioxide quantity to be contained in the air to cause the arterial carbon dioxide tension of the living subject to change.

14. A tissue oxygen measuring system according to claim 10 wherein said third measuring means comprises means for cyclically changing a rate of ventilation to cause the arterial carbon dioxide tension of the living subject to change.

15. A tissue oxygen measuring system according to claim 2, wherein said control means includes means for controlling said ventilator unit to cyclically change a rate of one of oxygen quantity and carbon dioxide quantity to be contained in the air.

16. A tissue oxygen measuring system according to claim 2 further comprising display means for displaying results computed by said data processing means.

17. A tissue oxygen measuring system according to claim 2 further comprising averaging means for averaging a plurality of data regarding each of the cerebral blood flow, the cerebral blood volume, and the ratio of change in cerebral blood volume to change in arterial carbon dioxide tension obtained through the cyclic changes of the gaseous contents of the air.