Dry dialysate composition

• US 5,252,213 A
• Filed: 11/09/1990
• Issued: 10/12/1993
• Est. Priority Date: 06/20/1989
• Status: Expired due to Term

• Current Assignee: University of Washington
• Original Assignee: University of Washington
• Inventors: Jensen, William, Cole, James J., Ahmad, Suhail
• Primary Examiner(s): Dawson, Robert A.
• Assistant Examiner(s): KIM, SUN U
• Application Number:
  US07/612,214
• Time in Patent Office: 1,068 Days
• Field of Search: 210/96.1, 210/96.2, 210/206, 210/321.6, 210/321.71, 210/321.72-321.81, 210/424, 210/541, 210/542, 210/646, 252/1, 252/363.5, 252/183.16, 252/190, 424/677, 424/678, 424/679, 424/680, 424/681
• US Class Current: 210/542
• CPC Class Codes: A61M 1/1666 by dissolving solids
• CPC Class Codes: A61M 1/168 Sterilisation or cleaning before or after use
• CPC Class Codes: A61M 1/1682 both machine and membrane module, i.e. also the module blood side
• CPC Class Codes: A61M 1/1684 Checking the module characteristics before reuse
• CPC Class Codes: A61M 1/169 using chemical substances
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/302 having a reservoir for withdrawn untreated blood
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/306 Pressure control, e.g. using substantially rigid closed or gas buffered or elastic reservoirs
• CPC Class Codes: A61M 1/3417 using distinct filters for dialysis and ultra-filtration
• CPC Class Codes: A61M 1/3427 back through the membrane, e.g. by inverted trans-membrane pressure [TMP]
• CPC Class Codes: A61M 1/3437 downstream of the filter, e.g. post-dilution with filtrate
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3644 Mode of operation
• CPC Class Codes: A61M 1/3646 Expelling the residual body fluid after use, e.g. back to the body
• CPC Class Codes: A61M 1/3649 using dialysate as priming or rinsing liquid
• CPC Class Codes: A61M 2205/705 Testing of filters for leaks blood in dialysate A61M1/1692
• CPC Class Codes: A61M 2205/707 Testing of filters for clogging
• CPC Class Codes: A61M 60/113 in other functional devices, e.g. dialysers or heart-lung machines
• CPC Class Codes: A61M 60/279 Peristaltic pumps, e.g. roller pumps
• CPC Class Codes: A61M 60/38 : Blood oxygenation
• CPC Class Codes: A61M 60/443 : with means converting the rotation into a translational movement of the displacement member
• CPC Class Codes: A61M 60/531 : using blood pressure data, e.g. from blood pressure sensors
• CPC Class Codes: A61M 60/554 : of blood pressure
• CPC Class Codes: A61M 60/562 : for making blood flow pulsatile in blood pumps that do not intrinsically create pulsatile flow
• CPC Class Codes: A61M 60/585 : User interfaces
• CPC Class Codes: A61M 60/853 : the valve being formed by a flexible tube element which is clamped for restricting the flow

Abstract

There is disclosed an automated hemodialysis filtration system comprising one or a plurality of the following improvements, including a supply-regulated pump, an inverted drip chamber, a filtrate system communicating with a hemofilter and comprising a filtrate reservoir, a filter pump and pressure sensors, and a means for adding dry pellets to water to form the dialysate.

Claims

1. A dry dialysate composition comprising an acid, bicarbonate and a salt, where the acid is separated from the bicarbonate, wherein the acid will dissolve first in an aqueous solution and the bicarbonate will dissolve after solution of the acid, and where said composition upon mixing with water forms a solution comprising from about 2 to about 12 mEq/L of the acid, from about 25 to about 45 mEq/L of the bicarbonate, and from about 1.5 to about 150 mEq/L of the salt.

2. The dry dialysate composition of claim 1 wherein the acid is citric acid.

3. The dry dialysate composition of claim 1 wherein, upon dissolving in water, the pH is about 7.0 to below 7.4

4. A dry dialysate composition comprising bicarbonate, acetate, lactate or combinations thereof, sodium, calcium, chloride, citric acid, and optionally potassium, magnesium, and glucose, wherein said composition, upon mixing with water, forms a solution comprising:

from about 130 to about 150 mEq/L of sodium ion;

from about 0 to about 4.0 mEq/L of potassium ion;

from about 2.0 to about 3.5 mEq/L of calcium ion;

from about 0 to about 1.5 mEq/L of magnesium ion;

from about 25 to about 45 mEq/L of bicarbonate ion;

acetate, lactate or combinations thereof;

from about 0 to about 2.0% glucose;

from about 90 to about 120 mEq/L of chloride ion; and

from about 2 to about 12 mEq/L of citric acid.

5. A dry dialysate composition comprising an acid, a base and a salt wherein the acid is selected from the group consisting of citric acid, lactic acid, ascorbic acid, acetic acid and combinations thereof, wherein the base is selected from the group consisting of bicarbonate, carbonate, lactate, citrate and combinations thereof, and where said composition upon mixing with water forms a solution comprising from about 2 to about 12 mEq/L of the acid, from about 25 to about 45 mEq/L of the base, and from about 1.5 to about 150 mEq/L of the salt.

6. A dry dialysate composition comprising bicarbonate, acetate, lactate or combinations thereof, sodium, calcium, chloride, and citric acid, wherein said composition, upon mixing with water, forms a solution comprising:

from about 130 to about 150 mEq/L of sodium ion;

from about 2.0 to about 3.5 mEq/L of calcium ion;

from about 35 to about 45 mEq/L of bicarbonate ion;

acetate, lactate or combinations thereof;

from about 90 to about 120 mEq/L of chloride ion; and

from about 2 to about 12 mEq/L of citric acid.

7. A dry dialysate composition comprising an acid, a base and a salt wherein the acid is selected from the group consisting of citric acid, ascorbic acid and combinations thereof, wherein the base is selected from the group consisting of bicarbonate, carbonate, lactate, citrate and combinations thereof, and where said composition upon mixing with water forms a solution comprising from about 2 to about 12 mEq/L of the acid, from about 25 to about 45 mEq/L of the base, and from about 1.5 to about 150 mEq/L of the salt.