Diagnostic apparatus for measuring changes of arterial and venous blood volumes in brain with respiration signal modulation

• US 5,253,646 A
• Filed: 03/18/1992
• Issued: 10/19/1993
• Est. Priority Date: 12/30/1991
• Status: Expired due to Term

• Current Assignee: Hamamatsu Photonics KK
• Original Assignee: Hamamatsu Photonics KK
• Inventors: Cope, Mark, Delpy, David T.
• Primary Examiner(s): Howell, Kyle L.
• Assistant Examiner(s): GILBERT, SAMUEL G
• Application Number:
  US07/853,183
• Time in Patent Office: 580 Days
• Field of Search: 126/633, 126/634, 126/664, 126/665, 126/670, 126/671
• US Class Current: 600/310
• CPC Class Codes: A61B 5/14553 specially adapted for cerebral tissue

Abstract

A diagnostic apparatus includes light sources which emit near infrared light rays of different wavelengths. The light rays are introduced into human brain to be subjected to diagnosis and the light rays transmitted through the brain are picked up. There are provided a first detector which detects occurrences of respirations of the subject and outputs a respiration signal, and a second detector which detects occurrences of heartbeats of the subject and outputs a heartbeat signal. The light transmitted through the brain is derived in synchronism with both the respiration signal and the heartbeat signal and first and second modulated light transmission signals are produced which are respectively modulated by the respiration signal and the heartbeat signal. The first and second modulated light transmission signals are separately analyzed to provide variations in concentration of oxygenated media ΔX₀₂ and disoxygenated media ΔX contained in venous and arterial blood of the brain, respectively. Based thereon, oxygen saturations of both venous and arterial blood flowing in the brain are separately computed and displayed in a monitor screen.

Claims

1. An apparatus used for diagnosing a living subject, comprising:

light source means for emitting light of different wavelength;

light introducing/receiving means for introducing said light into a brain of the living subject and receiving light transmitted through the brain;

detecting means for detecting occurrences of respirations of the living subject and outputting a respiration signal indicative of said occurrences of said respirations;

deriving means for deriving the transmitted light from said introducing/receiving means in synchronism with the respiration signal and outputting a modulated light transmission signal indicative of the transmitted light which is modulated by the respiration signal;

analyzing means for analyzing the modulated light transmission signal and providing an operation result, the operation result indicating variations in concentration of oxygenated media Δ

X₀₂ and disoxygenated media Δ

X contained in venous blood of the brain;

operation means for performing an arithmetic operation of

space="preserve" listing-type="equation">K.sub.1 ×

Δ

X.sub.02 /{Δ

X+Δ

X.sub.02 }

where K₁ is a first predetermined constant, a result of the arithmetic operation indicating an oxygen saturation in the venous blood of the brain; and

displaying means for displaying the result of the arithmetic operation.

2. A diagnostic apparatus according to claim 1, further comprising second detecting means for detecting occurrences of heartbeats of the living subject and outputting a heartbeat signal indicative of occurrences of the heartbeats, and second deriving means for deriving the light from said introducing/receiving means in synchronism with the heartbeat signal and outputting a second modulated light transmission signal indicative of the transmitted light which is modulated by the heartbeat signal, wherein said analyzing means further analyzes the second modulated light transmission signal and providing another operation result, said another operation result indicating variations in concentration of oxygenated media Δ

X₀₂ and disoxygenated media Δ

X contained in arterial blood of the brain, wherein said operation means further performs another arithmetic operation of

space="preserve" listing-type="equation">K.sub.2 ×

Δ

X.sub.02 /{Δ

X+Δ

X.sub.02 }

with respect to the variations in concentration of oxygenated media Δ

X₀₂ and disoxygenated media Δ

X contained in arterial blood of the brain, where K₂ is a second predetermined constant, a result of said another arithmetic operation indicating an oxygen saturation in the arterial blood of the brain, and wherein said displaying means further displays the result of said another arithmetic operation.

3. A diagnostic apparatus according to claim 2, wherein said display means comprises means for substantially simultaneously displaying the result of the arithmetic operation and the result of said another arithmetic operation.

4. A diagnostic apparatus according to claim 2, wherein said display means comprises means for selectively displaying the result of the arithmetic operation and the result of said another arithmetic operation.

5. A diagnostic apparatus according to claim 1 wherein the light introducing means comprises means for introducing near infrared light.

6. A diagnostic apparatus according to claim 1, wherein the light introducing means comprises means for repeatedly introducing light of different wavelengths into the brain each for a predetermined period of time and wherein the operation means for performing said arithmetic operating performs only when a value of is equal to or larger than a predetermined minimum.