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Biological material deployment method and apparatus

  • US 5,256,141 A
  • Filed: 12/22/1992
  • Issued: 10/26/1993
  • Est. Priority Date: 12/22/1992
  • Status: Expired due to Fees
First Claim
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1. A system for the deployment of biologically active material in vascular wall tissue of a vascular segment of interest, the device being in the form of an elongated multi-lumen catheter having a plurality of serially situated functional zones comprising:

  • an externally accessed dispersion zone adapted to address a vascular segment and having a perforated dispersion lumen chamber subtending a major arc of the vascular circumference provided with a pattern of openings for deploying biologically active materials in the vascular segment supplied through an externally connected lumen;

    an electrode means with the dispersion zone for applying a controlled electrical charge to the biologically active material at the point of deployment;

    a pair of spaced inflatable balloons defining a pair of occlusion zones for temporarily occluding normal vascular blood flow in the vascular segment of interest during deployment of the biologically active materials;

    flow bypass means comprising a lumen connecting proximal and distal infusion port zones for maintaining at least a minimum blood flow about and beyond the vascular segment of interest during the occlusion thereof; and

    control interface means for controlling operation of the system including means capable of the time-variable modulation of the charge applied by the electrode means.

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