Physician closed-loop neuromuscular blocking agent system

• US 5,256,156 A
• Filed: 01/13/1992
• Issued: 10/26/1993
• Est. Priority Date: 01/31/1991
• Status: Expired due to Fees

• Current Assignee: Baxter International Inc.
• Original Assignee: Baxter International Inc.
• Inventors: Kern, Steven E., Skakoon, James G., Westenskow, Dwayne R.
• Primary Examiner(s): Rosenbaum, C. Fred
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US07/821,168
• Time in Patent Office: 652 Days
• Field of Search: 128/DIG. 12, 128/DIG. 13, 604/246, 604/67, 604/141, 604/27, 604/28, 604/31, 604/50, 604/52, 604/65
• US Class Current: 604/246
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 20/30 relating to physical therapies or activities, e.g. physiotherapy, acupressure or exercising
• CPC Class Codes: Y10S 128/13 Infusion monitoring

Abstract

A semi-automatic infusion system for administration of neuromuscular agents and the like includes a microcomputer-controlled infusion pump with a data input pad. A clinician enters the desired paralysis level and performs periodically an electro-stimulation test to determine the actual paralysis level of the patient. This information is also entered in to the system by the physician which then calculates and administers a new dosage.

Claims

1. An apparatus for administering a neuromuscular blocking agent to a patient to induce paralysis, said apparatus comprising:

means for pumping a neuromuscular blocking agent to a patient;

means for controlling the operation of said means for pumping, including manual controls for manually setting the preliminary desired operation of said pumping means and further including means for entering the desired results of patient electro-stimulation test; and

means for periodically entering the actual results of patient electro-stimulation tests;

wherein said means for controlling alters the operation of said pumping means when said actual results differ from said desired results.

2. The apparatus of claim 1 wherein said electro-stimulation test is a train-of-four test.

3. The apparatus of claim 1 further comprising replaceable memory means, said replaceable memory means being tailored to match a preselected electro-stimulation test, preselected therapeutic agent, preselected therapeutic time course, or combination thereof.

4. The apparatus of claim 1 wherein said means for pumping comprises an infusion pump.

5. An apparatus for administering a neuromuscular blocking agent into a patient to induce a selectable level of paralysis, said apparatus comprising:

infusion pump means for infusing said agent to said patient;

microprocessor means coupled to said infusion pump means for controlling the operation thereof;

data input means coupled to said microprocessor means for entering a first signal indicative of a desired paralysis level and a second signal indicative of the actual paralysis level of said patient based on a preselected test; and

memory means for storing a program for said microprocessor corresponding to said agent and said test, responsive to which program, said microprocessor determines the operation of said infusion pump.

6. The apparatus of claim 5 wherein said infusion pump operates in a continuous mode.

7. The apparatus of claim 5 wherein said infusion pump delivers said agent in a bolus mode.

8. The apparatus of claim 5 wherein said memory means comprises a replaceable ROM.

9. The apparatus of claim 5 wherein said second signal corresponds to the results of a train-of-four test.

10. The apparatus of claim 5 further comprising display means for displaying instructions.

11. A method of administering a neuromuscular blocking agent for inducing a preselectable level of paralysis on a patient comprising the steps of:

providing an infusion pump system for infusing said patient;

microprocessor means coupled to said infusion pump system for controlling the operation thereof;

data input means coupled to said microprocessor;

entering in said data input means a predetermined level of paralysis;

monitoring said patient to determine his actual level of paralysis;

entering said actual level in said data input means; and

adjusting the infusion of said agent to said patient in accordance with the difference between said actual and predetermined level of paralysis.

12. The method of claim 11 wherein said actual paralysis level is determined by conducting a electro-stimulation test.

13. The method of claim 12 wherein said test is a train-of-four test.

14. The method of claim 11 wherein said infusion pump system includes a replaceable memory unit, and further comprising the step of installing a memory unit corresponding to a preselected agent and test.

15. The method of claim 11 further comprising the step of administering an initial dose of said agent to establish paralysis in said patient by administering a multiple of the ED95 dose.