Synthetic buffer composition for clinical use

• US 5,256,660 A
• Filed: 03/17/1992
• Issued: 10/26/1993
• Est. Priority Date: 12/14/1987
• Status: Expired due to Term

• Current Assignee: Geraldine F. Swan, Trust
• Original Assignee: Henry Swan II, Trust
• Inventors: Swan, Henry
• Primary Examiner(s): Shah, Mukund J.
• Assistant Examiner(s): Datlow, Philip I.
• Application Number:
  US07/852,659
• Time in Patent Office: 588 Days
• Field of Search: 514/238.8, 514/255, 514/578
• US Class Current: 514/238.8
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/13 Amines A61K31/04 takes precedence
• CPC Class Codes: A61K 31/185 Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids hydroxamic acids A61K31/16; peroxy acids A61K31/327
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 31/535 having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines

Abstract

Methods of administering aqueous synthetic buffer compositions of an N-substituted aminosulfonic acid and a sodium salt of a different substituted aminosulfonic acid suitable to treat oligemic, respiratory and metabolic acidosis are disclosed. Methods of administering aqueous synthetic buffer compositions of a different N-substituted aminosulfonic acid, a sodium salt of an N-substituted aminosulfonic acid and tris(hydroxymethyl)aminomethane which may be similarly employed are also disclosed.

Claims

1. A method for treating acidosis in a patient, said method comprising administering to a patient in need thereof an effective amount of a buffering solution, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

2. The method defined in claim 1 wherein the buffering solution is further comprised of TRIS.

3. The method defined in claim 1 or 2 wherein the buffering solution has a pH of approximately 7.2 to 7.8 at an approximate temperature of 37°

C.

4. The method defined in claim 1 or 2 wherein the buffering solution has a molar strength of approximately 0.1 to 0.5M.

5. The method defined in claim 1 or 2 wherein the buffering solution has a pKa of approximately 7.4 to 7.8 at approximately 37°

C.

6. The method defined in claim 1 or 2 wherein the buffering solution has a Δ

pK/C°

of approximately 0.014 to 0.020.

7. The method defined in claim 1 or 2 wherein the buffering solution has an osmolality of approximately 270 to 500 mOsm.

8. The method defined in claim 1 or 2 wherein the buffering solution has a sodium ion concentration of approximately 0.035 to 0.35M.

9. The method defined in claim 2 wherein the N-substituted aminosulfonic acid is TAPSO and the sodium salt is NaDIPSO.

10. The method defined in claim 9 wherein the TAPSO is present in a concentration of approximately 47 grams per liter, the NaDIPSO is present in a concentration of approximately 37 grams per liter and the TRIS is present in a concentration of approximately 3 grams per liter.

11. A method for treating general and myocardial acidosis of a patient subjected to trauma and/or hemorrhage, said method comprising administering to a patient in need thereof an effective amount of a buffering solution, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

12. A method as defined in claim 11 wherein the buffering solution is further comprised of TRIS.

13. The method defined in claim 11 or 12 wherein the buffering solution has a molar strength of approximately 0.2 to 0.5M.

14. The method defined in claim 11 or 12 wherein the buffering solution has a pKa of approximately 7.2 to 7.4 at approximately 37°

C.

15. The method defined in claim 11 wherein the N-substituted aminosulfonic acid is HEPES and the sodium salts selected are NaTAPSO and NaMOPS.

16. The method defined in claim 15 wherein the HEPES, NaTAPSO and NaMOPS are present in a molar ratio of 5:

4;

1.

17. The method defined in claim 11 wherein the N-substituted aminosulfonic acid is HEPES, the salts selected are NaDIPSO and NaMOPS and the HEPES, NaDIPSO and NaMOPS are present in a molar ratio of 4:

5;

1.

18. A method to protect the blood pH and the myocardial pH of a patient suffering acute circulatory insufficiency associated with or due to decreased coronary blood flow, said method comprising administering to a patient in need thereof an effective amount of a buffering solution, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

19. A method as defined in claim 18 wherein the buffering solution is further comprised of TRIS.

20. The method defined in claim 18 or 19 wherein the buffering solution has a pKa of approximately 7.1 to 7.4 at approximately 37°

C.

21. The method defined in claim 18 or 19 wherein the buffering solution has a sodium ion concentration of up to approximately 0.150M.

22. The method defined in claim 19 wherein the N-substituted aminosulfonic acid is MOPS and the sodium salt is NaHEPES.

23. The method defined in claim 22 wherein MOPS, NaHEPES and TRIS are present in a molar ratio of 6:

3;

1.

24. A method for buffering the blood pH and the myocardial pH of a hypothermic patient, said method comprising administering to a patient in need thereof an effective amount of a buffering solution, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

25. A method as defined in claim 24 wherein the buffering solution is further comprised of TRIS.

26. The method defined in claim 24 or 25 wherein the buffering solution has a pH of approximately 7.4 to 7.8 at an approximately temperature of 25°

C.

27. A method for buffering the blood pH and the myocardial pH of a hypothermic patient during cardiac surgery with circulatory occlusion, said method comprising administering to a patient in need thereof an effective amount of a buffering solution by coronary infusion, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

28. The method defined in claim 27 wherein the buffer solution is further comprised of TRIS.

29. The method defined in claim 27 wherein the N-substituted aminosulfonic acid is HEPES and the sodium salt is NaMOPS.

30. The method defined in claim 29 wherein HEPES and NaMOPS are present in a molar ratio of 3:

7.

31. A method for buffering the blood pH and the myocardial pH of a hypothermic patient undergoing cardiopulmonary bypass, said method comprising adding a buffering solution to a primary fluid of a heart-lung machine, said buffering solution comprised of:

(a) water;

(b) at least one N-substituted aminosulfonic acid selected from the group consisting of BES, DIPSO, HEPES, MOPS, MOPSO, TAPSO and TES; and

(c) at least one sodium salt of an N-substituted aminosulfonic acid selected from the group consisting of NaBES, NaDIPSO, NaHEPES, NaMOPS, NaMOPSO, NaTAPSO and NaTES where the N-substituted aminosulfonic acid from which the sodium salt is formed is different than the N-substituted aminosulfonic acid selected in (b).

32. The method defined in claim 31 wherein the buffer solution is further comprised of TRIS.