Microprocessor-based biomedical monitoring apparatus and method

• US 5,258,314 A
• Filed: 08/20/1992
• Issued: 11/02/1993
• Est. Priority Date: 03/18/1991
• Status: Expired due to Fees

• Current Assignee: Paradigm Biotechnologies Partnership
• Original Assignee: Paradigm Biotechnologies Partnership
• Inventors: Skerratt, Brenda L.
• Primary Examiner(s): Housel, James C.
• Assistant Examiner(s): Soderquist, Arlen
• Application Number:
  US07/931,453
• Time in Patent Office: 439 Days
• Field of Search: 422/58, 422/63, 422/66, 422/67, 422/81, 422/82.05, 422/82.09, 422/100, 422/102, 436/43, 436/165, 206/219
• US Class Current: 436/165
• CPC Class Codes: B01L 2400/0481 squeezing of channels or chambers
• CPC Class Codes: B01L 3/505 flexible containers not provided for above
• CPC Class Codes: G01N 1/2035 by deviating part of a fluid stream, e.g. by drawing-off or tapping
• CPC Class Codes: G01N 33/528 Atypical element structures, e.g. gloves, rods, tampons, toilet paper
• CPC Class Codes: Y10T 436/11 Automated chemical analysis

Abstract

A microprocessor-based, control unit for analysis of a fluid sample, and for especially biomedical analysis of a body fluid, is provided. Also provided is the combination of a roller assembly and a compartmentalized pouch containing certain chemicals, with the rollers functioning to break rupturable seals of compartments and to push fluids from one compartment to another. Apparatus in accordance with the present invention, is useful, for example, in monitoring urea concentration during dialysis.

Claims

1. Microprocessor-based, self-contained, biomedical monitoring apparatus comprising a control unit comprising a microprocessor and programmable memory in operative communication with means for data input and means for informing as to an analytical value obtained;

a microprocessor-controlled, pressure-exerting assembly;

an internal power source for said control unit and said pressure-exerting assembly;

a compartmentalized, analysis device having an inlet coupled to a source of multiple samlpes in the form of a separate device, said separate device being an exteriorly located, blood plasma-separating device, and comprising a compressible reagent chamber and compressible reaction chamber, said reagent chamber being adapted for fluid communication with said reaction chamber, which has outflow means in fluid communication with a flow through, analysis cell for microprocessor-controlled delivery of analyzable liquid to said analysis cell; and

analytical sensor means situated adjacent said analysis cell, said microprocessor being in operative communication with said analytical sensor means for analysis of said analyzable liquid.

2. The microprocessor-based, monitoring apparatus of claim 1, wherein said analytical sensor means is photometric analysis means.

3. The microprocessor-based, monitoring apparatus of claim 1, wherein said flow through, analysis cell is in fluid communication with a waste container for said analyzable liquid.

4. A method for microprocessor-based, biomedical monitoring comprising providing a self-contained, biomedical monitoring apparatus comprising a control unit comprising a microprocessor and programmable memory in operative communication with means for data input and means for informing as to an analytical value obtained, a microprocessor-controlled, pressure-exerting assembly, and a compartmentalized, analysis device having compressible chambers, an inlet, and a conduit for delivery of an analyzable liquid to a flow through, analysis cell;

coupling said inlet to a source of multiple samples in the form of a separate device, said separate device being an exteriorly located, blood plasma-separating device;

thereafter, admitting a selected volume of plasma into a compressible reaction chamber of said analysis device;

under microprocessor control and with said inlet coupled to said blood plasma-separating device, providing for communication between a compressible reagent chamber and said compressible reaction chamber, and delivering a suitable amount of a reagent into said compressible reaction chamber;

thereafter, under microprocessor control, providing for fluid communication between said compressible reaction chamber and said analysis cell, and delivering said analyzable liquid into said analysis cell; and

thereafter, under microprocessor control, analyzing said analyzable liquid in said analysis cell, and informing as to the analytical value obtained.

5. The microprocessor-based, biomedical monitoring method of claim 4, further comprising, under microprocessor control, passing said analyzable liquid to a waste container.

6. The microprocessor-based, biomedical monitoring method of claim 4, wherein photometric analysis of said analyzable liquid is used.

7. The microprocessor-based, biomedical monitoring method of claim 4, wherein said analysis device comprises a second compressible reagent chamber, and wherein said method further comprises, under microprocessor control, providing for communication between said second reagent chamber and said compressible reaction chamber.