Photolabile reagents for incorporation into oligonucleotide chains
First Claim
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1. A polynucleotide reagent having the structure ##STR7## wherein DNA1 is a first segment of DNA;
- DNA2 is a second segment of DNA; and
one of x and y is zero while the other is an integer in the range of 1 to 12 inclusive.
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Abstract
Novel photolabile photochemical reagents are disclosed. The reagents are useful in a variety of biochemical and chemical contexts, including nucleic hybridization assays and chemical phosphorylation of hydroxyl-containing compounds. The reagents are particularly useful for introducing cleavable sites into oligonucleotide or polynucleotide chains, i.e., sites which are cleavable upon photolysis. The reagents are also useful in both 5'"'"'- and 3'"'"'-phosphorylation of oligonucleotide or polynucleotide chains.
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Citations
9 Claims
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1. A polynucleotide reagent having the structure ##STR7## wherein DNA1 is a first segment of DNA;
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DNA2 is a second segment of DNA; and one of x and y is zero while the other is an integer in the range of 1 to 12 inclusive. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification