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Sample pad assay initiation device

  • US 5,260,221 A
  • Filed: 07/02/1991
  • Issued: 11/09/1993
  • Est. Priority Date: 03/16/1989
  • Status: Expired due to Term
First Claim
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1. An analyte measuring device which cooperates with a signal producing system for producing a detectable signal in a detection zone, said device comprising:

  • a housing comprising a well adjacent to one end of said housing, a pouch enclosing a liquid for release into said well, a flow path for holding in position two bibulous strips spaced apart in tandem relationship to define a space, and proximal to said well an interspace for receiving a slide mechanism;

    an orifice for receiving a sample displaced from and substantially aligned with the space between said two bibulous strips;

    in said orifice for preparing plasma free of red blood cells from blood with minimal lysis of said red blood cells, a membrane system comprising first and second membranes, said first membrane being a coarse separation membrane, having a pore size greater than said second membrane;

    said second membrane in fluid-receiving relationship with said first membrane and having an average porosity in the range of about 0.65μ

    to 7μ

    , or an asymmetric membrane having a maximum porosity of greater than about 40μ and

    a minimum porosity of not less than about 0.4μ

    ;

    a slide element in said interspace comprising;

    (1) a sample receiving element positioned (i.) under said orifice when said slide element is in a first position, and (ii.) positioned in said space, when said slide is in a second position; and

    means for releasing a liquid into said well when said slide is moved from said first position to said second position; and

    first and second bibulous strips in said flow path, said first strip extending from said well to said space to transport liquid from said well to said sample receiving element and said second strip comprising said detection zone and extending from said space toward the end opposite from said well, wherein said second strip has non-diffusibly bound at least one member of said signal-producing system.

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