Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder

• US 5,260,324 A
• Filed: 11/06/1992
• Issued: 11/09/1993
• Est. Priority Date: 02/06/1990
• Status: Expired due to Term

• Current Assignee: GD Searle LLC (Pfizer Inc.)
• Original Assignee: GD Searle LLC (Pfizer Inc.)
• Inventors: Jans, Michel R., Cordi, Alex A.
• Primary Examiner(s): FRIEDMAN, STANLEY
• Application Number:
  US07/992,467
• Time in Patent Office: 368 Days
• Field of Search: 514/376, 514/561
• US Class Current: 514/376
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/42 Oxazoles

Abstract

A composition is described for use in memory and learning enhancement or for treatment of a cognitive disorder or a psychotic disorder. This composition contains the compound D-cycloserine and D-alanine and provides reduced adverse side effects typically associated with chronic D-cycloserine use.

Claims

1. A pharmaceutical dosage form comprising a therapeutically effective amount of D-cycloserine and a therapeutically-effective amount of D-alanine, along with one or more pharmaceutically-acceptable excipients, said D-cycloserine and said D-alanine being present in a therapeutically-effective ratio, said therapeutically-effective ratio being in a range of about 10-to-1 to about 100-to-1 of said D-alanine to said D-cycloserine, said D-cycloserine being present in an amount in a range from 2 mg to about 50 mg of D-cycloserine per unit dosage form.

2. The dosage form of claim 1 wherein said D-cycloserine is present in an amount in a range from about 3 mg to about 25 mg of D-cycloserine per unit dosage form.