Composite anesthetic article and method of use

• US 5,261,903 A
• Filed: 01/02/1991
• Issued: 11/16/1993
• Est. Priority Date: 04/11/1988
• Status: Expired due to Fees

• Current Assignee: MD, Inc.
• Original Assignee: MD, Inc.
• Inventors: Masih, Shabir Z., Dhaliwal, Avtar S.
• Primary Examiner(s): Hafer, Robert A.
• Assistant Examiner(s): RIMELL, SAMUEL G
• Application Number:
  US07/636,722
• Time in Patent Office: 1,049 Days
• Field of Search: 604/410, 604/416, 604/418, 128/203.12, 128/203.13, 128/203.16, 128/203.21, 424/715
• US Class Current: 604/416
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients

Abstract

An aqueous composition for reducing pain at the site of injection of local parenteral anesthetic material, for improving the onset thereof, and for increasing its duration, and a means for preparing and dispensing the same, the composition containing a local parenteral anesthetic which in normal doses gives an acid pH of from about 2.5 to about 6.9, wherein the anesthetic comprises from about 0.5 to about 2.0% by weight of the composition, the composition further containing sufficient NaHCO₃ to maintain the pH thereof between about 7.0 and about 7.6, and further containing from about 0.0004 moles of dissolved CO₂ per ml of composition up to the saturation level of dissolved CO₂ at a CO₂ head pressure of up to about 2.5 atmospheres.

Claims

1. A composite article useful in the buffering of normally acidic parenteral anesthetic material for reducing the adverse physiological effects thereof, said article comprising a vial having two chambers hermetically isolated from each other by valve means, said valve means comprising a sealing member slidably mounted in the vial and movable under pressure to a position which opens by-pass conduit means for fluid connecting the chambers, one of said chambers containing a dilute aqueous system of acid buffer material wherein the buffer material contains from about 0.0004 moles CO₂ /ml solution up to the saturation level of dissolved CO₂ at a CO₂ head pressure of up to about 2.5 atmospheres, the other of said chambers containing acidic parenteral anesthetic material, said valve means being responsive to pressure applied to at least one of said materials to form a fluid connection between said two chambers to allow intermixing of said materials.

2. A composite article useful in the buffering of normally acidic parenteral anesthetic material for reducing the adverse physiological effects thereof, said article comprising a vial having two chambers hermetically isolated from each other by valve means, one of said chambers containing a dilute aqueous system of acid buffer material, the other of said chambers containing acidic parenteral anesthetic material comprising one or a mixture of lidocaine hydrochloride or (-)-3, 4-dihydroxy-[(methylamino)methyl] benzyl alcohol, said valve means being responsive to pressure applied to at least one of said materials to form a fluid connection between said two chambers to allow intermixing of said materials.