Interferant eliminating biosensors
First Claim
Patent Images
1. A biosensor comprising:
- an electrode on which an analyte is electrooxidized at a given applied potential; and
an interferant-eliminating layer substantially covering the electrode but electrically isolated therefrom at the given applied potential, comprising a catalyst which is capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte.
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Abstract
A biosensor including an interferant-eliminating catalyst and method for analyzing an analyte in a biological sample is disclosed.
1387 Citations
20 Claims
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1. A biosensor comprising:
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an electrode on which an analyte is electrooxidized at a given applied potential; and an interferant-eliminating layer substantially covering the electrode but electrically isolated therefrom at the given applied potential, comprising a catalyst which is capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte.
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2. A biosensor comprising:
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an electrode on which an analyte is electrooxidized at a given applied potential; and an interferant-eliminating layer substantially covering the electrode but electrically isolated therefrom, comprising a preactivated, oxidized catalyst which is capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte. - View Dependent Claims (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A process for producing a preactivated interferant-eliminating biosensor, said process comprising the steps of:
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substantially covering an electrode on which an analyte is electrooxidized with an interferant-eliminating layer comprising a catalyst, said catalyst capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte; and reacting the catalyst with an oxidant to substantially increase the oxidation state of the catalyst and to form a stable, oxidized catalyst intermediate.
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17. A process for producing a preactivated, interferant-eliminating biosensor, said process comprising the steps of:
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substantially covering an enzyme electrode on which an analyte is electrooxidized with an interferant-eliminating layer containing a catalyst, said catalyst capable of catalyzing substantial oxidation of a plurality of interferants but not substantial oxidation of the analyte; reacting the catalyst with an oxidant to increase the oxidation state of the catalyst and to form a stable, oxidized catalyst intermediate.
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18. A process for analyzing analyte in the presence of a plurality of interferants in a test sample comprising the steps of:
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contacting a sample with a preactivated, interferant eliminating biosensor having an electrode and an interferant eliminating layer; substantially oxidizing interferants in the interferant eliminating layer; and detecting the analyte at the electrode in the absence of substantial interference. - View Dependent Claims (19, 20)
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Specification