Inhaler

• US 5,263,475 A
• Filed: 03/18/1992
• Issued: 11/23/1993
• Est. Priority Date: 03/21/1991
• Status: Expired due to Term

• Current Assignee: Novartis Corporation (Novartis Ag)
• Original Assignee: Ciba-Geigy Corporation (Novartis Ag)
• Inventors: Dubach, Werner F., Khanna, Satish C., Spaltenstein, Anton, Hilpert, Hanspeter, Altermatt, Daniel
• Primary Examiner(s): Burr, Edgar S.
• Assistant Examiner(s): RACITI, ERIC
• Application Number:
  US07/853,460
• Time in Patent Office: 615 Days
• Field of Search: 128/203.12, 128/203.21, 128/203.23, 128/202.21, 128/203.19, 128/200.24, 128/200.23, 128/203.15, 604/58, 222/510, 222/319, 222/336, 222/494
• US Class Current: 128/203.15
• CPC Class Codes: A61M 15/0015 located upstream of the dispenser, i.e. not traversed by the product
• CPC Class Codes: A61M 15/0028 using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0068 Indicating or counting the number of dispensed doses or of remaining doses
• CPC Class Codes: A61M 15/0073 on a ring
• CPC Class Codes: A61M 15/0076 on a drum
• CPC Class Codes: A61M 15/0081 Locking means
• CPC Class Codes: A61M 2202/064 Powder
• CPC Class Codes: A61M 2205/6081 Colour codes

Abstract

An inhaler for introducing a metered amount of solids, for example pharmaceutically active powders, into a stream of air drawn in by a user comprises a storage chamber into which a metering rod extends. The metering rod is provided with a metering recess which fixes the amount of solids to be mixed with the air stream. The storage chamber and the metering rod are movable relative to each other in such a manner that in a first relative position of the metering rod and the storage chamber the metering recess of the metering rod is located in the storage chamber, where it is filled with solids, and in a second relative position it is located in the air channel, where the solids are mixed with the air stream. The axial relative movement can be brought about by the rotation of two housing parts over sloping surfaces.

Claims

1. An inhaler for introducing a metered amount of pharmaceutically active powder or mixture of pharmaceutically active powders into a stream of air which is drawn in by a user, said stream of air and the pharmaceutically active powder or mixture of pharmaceutically active powders forming a powder/air mixture, said inhaler comprising:

a device body;

a storage chamber for storing the powder;

an air inlet;

an outlet for the powder/air mixture;

an air channel connecting said air inlet with said outlet for the powder/air mixture;

a metering rod provided with a recess to measure a fixed amount of powder and to introduce said fixed amount of powder into said stream of air;

a locking device; and

an unlocking element;

said storage chamber including a first opening through which said metering rod enters the storage chamber;

said metering rod extending axially into said storage chamber through the first opening in said storage chamber;

said storage chamber and said metering rod being movable relative to each other such that, in a first relative position said recess of said metering rod is located in said storage chamber and in a second relative position said recess is located in said air channel;

said locking device holding said storage chamber and said metering rod in said first relative position; and

said unlocking element releasing the locking device.

2. An inhaler according to claim 1 further comprising

an operating member;

and

a return spring;

said storage chamber further provided with an extension having a second opening;

said extension closing said air channel in said first relative position;

said second opening opening said air channel in said second relative position;

said operating member further provided with a vibration means;

said vibration means exercising vibrations on said storage chamber when said storage chamber is in said first relative position;

said vibration means comprising a snap spring.

3. An inhaler according to claim 1, further being provided with a separatable suction piece comprising at least a part of said air channel as well as an outlet of said inhaler, said part of said air channel having a cross-section that widens towards said outlet.

4. An inhaler according to claim 3, further comprising a separate closing cap which is adapted to fit onto said suction piece.

5. An inhaler according to claim 4, wherein a drying agent is provided in said closing cap.

6. An inhaler according to claim 1, wherein a one-way valve is provided at said air inlet.

7. An inhaler according to claim 1, further being provided with a resettable counter which is incremented when the first relative position of said metering rod and said storage chamber is reached.

8. An inhaler according to claim 1, wherein the solids comprise a pharmaceutically effective antiasthmatic substance.

9. An inhaler according to claim 8, wherein said pharmaceutically effective antiasthmatic substance is a mixture of formoterol and lactose.

10. An inhaler for introducing a metered amount of pharmaceutically active powder or mixture of pharmaceutically active powders into a stream of air which is drawn in by a user, said stream of air and the pharmaceutically active powder or mixture of pharmaceutically active powders forming a powder/air mixture, said inhaler comprising:

a device body;

a storage chamber for storing the powder;

an air inlet;

an outlet for the powder/air mixture;

an air channel connecting said air inlet with said outlet for the powder/air mixture;

a metering rod provided with a recess to measure a fixed amount of powder and to introduce said fixed amount of powder into said stream of air;

said storage chamber including an opening through which said metering rod enters the storage chamber;

said metering rod extending axially into said storage chamber through the opening in said storage chamber;

said storage chamber and said metering rod being movable relative to each other such that, in a first relative position said recess of said metering rod is located in said storage chamber and in a second relative position said recess is located in said air channel;

wherein said device body carries said metering rod, further comprising a housing part containing said storage chamber, said housing part and said device body being displaceable relative to each other from said first relative position of said storage chamber and said metering rod, upon axially pushing together said housing part and said device body, to said second relative position, upon axially moving apart said housing part and said device body;

wherein said housing part and said device body are rotatable relative to each other;

wherein at least one sloping surface is provided on said housing part or on said device body;

wherein at least one counter-member is provided on the sloping surface;

wherein the counter-member is guided on said sloping surface thereby converting the rotary movement of said housing part and said device body relative to each other into an axial movement.

11. An inhaler according to claim 10, wherein said housing part or said device body is provided with a plurality of sloping surfaces, wherein each sloping surface of said plurality of sloping surfaces has an equal gradient and equal length over its periphery;

and wherein said device body or said housing part respectively, is provided with a plurality of counter-members, said plurality of counter-members being guided on said plurality of sloping surfaces.

12. An inhaler according to claim 10, wherein four sloping surfaces are provided which extend over almost 90 degrees, said sloping surfaces being arranged level with one another and ascending in the same direction to final positions, and further wherein four corresponding projections are provided as counter-members to said four sloping surfaces, which are guided on said sloping surfaces, and wherein there are provided vertically oriented openings, return grooves or the like at the final positions of said sloping surfaces, in which said projections can slide back, so that said housing part containing said storage chamber and said device body carrying said metering rod can be pushed together to said first relative position.

13. An inhaler according to claim 12, wherein each of said return grooves is provided with a cam-like projection, over which each of said counter-members is displaceable, and further wherein in said return grooves there is provided at least one saw tooth projection having an inclined side and a vertically extending side, said vertically extending side being aligned with said sloping surface for said counter-members, said counter-members being axially displaceable over said inclined side of said saw tooth projection and being located behind said vertically extending side when said housing part and said device body are pushed together to said first relative position.

14. An inhaler according to claim 12, wherein said sloping surfaces are shaped as grooves, each corresponding to a sector of a screw thread, said grooves being arranged on an inside wall portion of said housing part.

15. An inhaler according to claim 10, further comprising a locking mechanism, a ratchet or the like, which is arranged at respective contact points between said housing part and said device body, which are rotatable relative to each other, said locking mechanism, ratchet or the like permitting a rotational movement of said housing part and said device body relative to each other in one rotational direction only.

16. An inhaler according to claim 15, wherein said locking mechanism comprises a ratchet wheel, said ratchet wheel comprising saw teeth;

said saw teeth located on said housing part or on said device body, said saw teeth spaced at equal intervals, said ratchet wheel further comprising counter-teeth or groups of counter-teeth;

said counter-teeth or groups of counter-teeth located on said device body or on said housing part, said locking mechanism further provided with catch intervals, wherein said counter-teeth are at an offset relative to one another in a circumferential direction, said offset of said counter-teeth relative to one another being so selected, that the catch intervals of said locking mechanism are smaller than the equal intervals.

17. An inhaler according to claim 16, wherein said saw teeth, said equal intervals between said saw teeth, and said counter-teeth are arranged along a circumference of said housing part or of said device body, respectively, and extend in an axial direction.

18. An inhaler according to claim 16, wherein said device body carrying said metering rod is at least partially provided with a double wall having an inner wall and an outer wall, wherein said counter-members are arranged along said inner wall of said double wall to project radially outward from said inner wall and cooperate with said sloping surfaces on said housing part, and wherein said outer wall of said double wall of said device body is arranged relative to the housing part such that it encloses a wall portion of said housing part which is provided with said sloping surfaces, and further wherein said outer wall of said double wall carries the counter-teeth for said ratchet wheel, said outer wall arranged on the outside of said housing part.

19. An inhaler according to claim 18, wherein said inner wall of said double wall of said device body and said wall portion of said housing part which is provided with said sloping surfaces, have a circular shape, and wherein at least a portion of said outer wall of said device body has a cross-section that differs from said circular shape such, that corner regions are formed between said walls, and further wherein, when air is drawn in through said corner regions, particularly after said housing part and said device body have been rotated relative to each other and/or have been moved apart from each other axially, said air is guided via openings, that are arranged near the base of said device body, and via at least one one-way valve to said air channel and to said metering rod.

20. An inhaler according to claim 18, wherein said outer wall of said device body is provided with an end face and said housing part is provided with a corresponding stop surface, and wherein in said first relative position, after said device body and said housing part have been pushed together, said end face rests against said stop surface thereby preventing the entering of any air and closing the interior of said inhaler in an airtight manner.

21. An inhaler according to claim 20, wherein said housing part and said device body, respectively, comprise an indicator ring and an indicator window, said indicator ring being rotated a small angular amount relative to said indicator window each time a metering operation is carried out.

22. An inhaler according to claim 21, wherein the rotational movement of said indicator ring and therefore the metering operation is blocked once a given maximum number of metering operations has been reached.

23. An inhaler according to claim 21, wherein said device body is provided with a gear wheel or an internal gearing, and wherein said indicator ring comprises a circumferential gearing, said indicator ring comprising said circumferential gearing being mounted eccentrically with respect to said internal gearing on said device body, the circumferential gearing of said indicator ring and the internal gearing or the gear wheel of said device body interlocking in a respective contact region, said circumferential gearing of said indicator ring and said internal gearing or said gear wheel of said device body each having a number of teeth, wherein the number of teeth of the circumferential gearing slightly differs from the number of teeth of the internal gearing or the gear wheel such, that said indicator ring has a rotational movement relative to said device body of 360°

or less when a given number of metering operations have been carried out.

24. An inhaler according to claim 23, wherein said indicator ring is provided with a stop and wherein said housing part is provided with a corresponding counter-stop, said stop and said corresponding counter-stop being located in a common plane in close vicinity to each other or touching each other prior to a first metering operation of the inhaler, said stop and said corresponding counter-stop moving apart along a generally circular path as an increasing number of metering operations is carried out, said stop and said corresponding counter-stop movable into two planes which are vertically offset relative to each other when said housing and said device body are rotated relative to each other and simultaneously are axially displaced relative to each other during a metering operation, and said stop and said corresponding counter-stop returning to said common plane when said housing part and said device body are pushed together axially, the arrangement of said stop and said corresponding counter-stop being such, that they come to lie above each other after the maximum number of metering operations has been carried out, thereby preventing said housing part and said device body from being pushed together again.

25. An inhaler according to claim 10, further comprising:

a piston and

a weak spring;

said piston being housed in said storage chamber;

said piston moving with said solids in said storage chamber as the storage chamber empties;

said weak spring sufficiently weak to prevent compression of said powder contained in said storage chamber;

said weak spring being sufficiently strong to push said piston against the weight of said powder and against the weight of said piston.

26. An inhaler according to claim 10, wherein said storage chamber is arranged inside said housing part, said storage chamber being removable and replaceable.

27. An inhaler according to claim 26, further comprising a closure;

said closure provided for the passageway of said metering rod, said closure being pierceable, said closure having predetermined breaking points, said closure opening automatically upon insertion of said storage chamber into said housing part.

28. An inhaler according to claim 10, wherein said storage chamber is provided with a removable cover.