Methods and means for non-invasive, dynamic tracking of cardiac vulnerability by simultaneous analysis of heart rate variability and T-wave alternans
First Claim
1. A method of tracking and diagnosing cardiac vulnerability comprising the steps of:
- sensing an ECG signal from a heart, said ECG signal having a plurality of R-R intervals, each R-R interval including an R-wave and a T-wave;
analyzing said T-waves to estimate an amplitude of beat-to-beat alternation, said amplitude of beat-to-beat alternation representing cardiac electrical instability;
analyzing said R-R intervals to estimate a magnitude of a high frequency component of heart rate variability and to estimate a magnitude of a low frequency component of heart rate variability, said magnitude of said high frequency component indicating parasympathetic neural influence on the heart, said low frequency component indicating combined sympathetic and parasympathetic neural influence on the heart; and
analyzing said amplitude of beat-to-beat alternation, said magnitude of said high frequency component of heart rate variability, and said magnitude of said low frequency component of heart rate variability to diagnose said cardiac electrical instability.
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Abstract
A method and apparatus for the non-invasive, dynamic tracking and diagnosing of cardiac vulnerability to ventricular fibrillation are disclosed. T-wave alternans and heart rate variability are simultaneously evaluated. T-wave alternation is an absolute predictor of cardiac electrical instability. Heart rate variability is a measure of autonomic influence, a major factor in triggering cardiac arrythmias. By simultaneously analyzing both phenomena, the extent and cause of cardiac vulnerability can be assessed. The method includes the following steps. An ECG signal is sensed from a heart. The T-wave portions of the ECG signal are analyzed to estimate an amplitude of beat-to-beat alternation. The amplitude of beat-to-beat alternation represents cardiac electrical instability. The R-R intervals are analyzed to estimate a magnitude of a high frequency component of heart rate variability and to estimate a magnitude of a low frequency component of heart rate variability. The high frequency component indicates parasympathetic activity. The low frequency component indicates combined sympathetic activity and parasympathetic activity. The amplitude of beat-to-beat alternation, the high frequency component of heart rate variability, and the low frequency component of heart rate variability are simultaneously analyzed to diagnose cardiac electrical instability.
128 Citations
15 Claims
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1. A method of tracking and diagnosing cardiac vulnerability comprising the steps of:
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sensing an ECG signal from a heart, said ECG signal having a plurality of R-R intervals, each R-R interval including an R-wave and a T-wave; analyzing said T-waves to estimate an amplitude of beat-to-beat alternation, said amplitude of beat-to-beat alternation representing cardiac electrical instability; analyzing said R-R intervals to estimate a magnitude of a high frequency component of heart rate variability and to estimate a magnitude of a low frequency component of heart rate variability, said magnitude of said high frequency component indicating parasympathetic neural influence on the heart, said low frequency component indicating combined sympathetic and parasympathetic neural influence on the heart; and analyzing said amplitude of beat-to-beat alternation, said magnitude of said high frequency component of heart rate variability, and said magnitude of said low frequency component of heart rate variability to diagnose said cardiac electrical instability. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method of tracking and diagnosing cardiac vulnerability comprising the steps of:
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sensing an ECG signal from a heart, said ECG signal including a plurality of R-R intervals and a plurality of T-waves; analyzing said T-waves to estimate an amplitude of beat-to-beat alternation, said amplitude of beat-to-beat alternation representing cardiac electrical instability. analyzing said R-R intervals to characterize heart rate variability; estimating the magnitude of a high frequency component of heart rate variability, said magnitude of said high frequency component indicating parasympathetic activity; estimating the magnitude of a low frequency component of heart rate variability; forming a ratio of said low frequency and said high frequency components of heart rate variability, said ratio indicating sympathetic activity; and analyzing said amplitude of beat-to-beat alternation, said magnitude of said low frequency component of heart rate variability, and said ratio of said low frequency and said high frequency components of heart rate variability to diagnose said cardiac electrical instability. - View Dependent Claims (10, 11, 12, 13, 14)
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15. An apparatus for dynamically tracking and diagnosing cardiac vulnerability by simultaneously analyzing T-wave alternation and heart rate variability in an ECG having a plurality of R-R intervals, said apparatus comprising:
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means for sampling the ECG; means for predicting the location in the ECG signal of the T-wave in each R-R interval; means for analyzing said T-waves to determine an amplitude of beat-to-beat alternation; means for computing the magnitude of each R-R interval to determine a heart rate; means for analyzing said heart rate to determine a variability therein, for computing a magnitude of a high frequency component of said variability indicative of parasympathetic neural influence on a heart and a magnitude of a low frequency component of said variability indicative of combined sympathetic and parasympathetic neural influence on said heart, and for computing a ratio of said low frequency component to said high frequency component, said ratio indicating sympathetic neural influence on said heart; and means for presenting said amplitude of beat-to-beat alternation, said high frequency component of said variability and said ratio to a user.
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Specification